Ventilator-coupled sampling device and method
A sample collection device collects Volatile Organic Compounds (VOCs) in exhaled breath in the outlet of a breathing assisted ventilator. The sample collection device is attached to the ventilator outlet line through a coupler containing either two check valves, or a check valve and a restrictive outlet flow path. During sampling, the exhaled air flows through a sorbent contained in the sample collection device as the ventilator pressure increases and decreases during the assisted breathing process. The flow of the exhaled air through the sample collection system is driven by the alternating pressure in the ventilator line without the need for an additional pump or power supply separate from the ventilator pump and power supply. The sample collection device can be used to monitor levels of bacteria-produced VOCs as an early detection of pneumonia and to allow feedback on the effectiveness of antibiotic treatment.
1. A ventilator diagnostic VOC sample collection system comprising:
a sample collection device, the sample collection device including a cavity containing one or more sorbents;
a valve system coupled to an opening of the cavity of the sample collection system, the valve system comprising a first one-way valve that allows flow of gas into the sample collection system and a second one-way valve that allows flow of gas out of the sample collection system; and
a sleeve having a volume including a fluid conveyance from a port of the sample collection device to the second one-way valve of the valve system, the sleeve being configured to accommodate the sample collection device and configured to be coupled to the valve system, wherein:
the valve system is configured to be coupled to a ventilator outlet line,
the sample collection system is configured to allow the flow of gas into the sample collection system to occur during periodic inspiration pulses of an inspiration cycle of the ventilator,
the sample collection system is configured to allow the flow of gas out of the sample collection system to occur between the inspiration pulses of the inspiration cycle of the ventilator,
a pump of the ventilator increases pressure in the ventilator outlet line during the inspiration pulses of the ventilator,
the flow of gas into the sample collection system is actuated by the pump of the ventilator that is coupled to the sample collection system by way of the ventilator outlet line,
the flow of gas out of the sample collection system is facilitated by an outlet valve of the ventilator, and
a distance between the one or more sorbents and the opening of the cavity of the sample collection system is less than a distance between the port and the opening of the cavity of the sample collection system.
2. The ventilator diagnostic VOC sample collection system of claim 1 , further comprising:
a reservoir fluidly coupled to the first one-way valve of the valve system and the opening of the cavity of the sample collection device.
3. The ventilator diagnostic VOC sample collection system of claim 2 , wherein the sample collection system is further configured to:
allow the flow of gas into the reservoir during the inspiration pulses; and
allow the flow of gas out of the reservoir and into the sample collection device between the inspiration pulses.
4. The ventilator diagnostic VOC sample collection system of claim 1 , wherein the sample collection system does not include a pump other than the pump of the ventilator.
5. The ventilator diagnostic VOC sample collection system of claim 1 , wherein the gas is exhaled air.
6. The ventilator diagnostic VOC sample collection system of claim 1 , further comprising a sampling indicator, wherein the sampling indicator is one of a balloon, a diaphragm, a switch, a pressure gauge, or a pressure sensor.
7. A ventilator system comprising:
an outlet line; and
a pump configured to increase pressure in the outlet line of the ventilator during periodic inspiration pulses of an inspiration cycle of the ventilator; and
a sample collection system comprising:
a sample collection device, the sample collection device including a cavity containing one or more sorbents;
a valve system coupled to an opening of the cavity of the sample collection system, the valve system comprising a first one-way valve that allows flow of gas into the sample collection system and a second one-way valve that allows flow of gas out of the sample collection system; and
a sleeve having a volume including a fluid conveyance from a port of the sample collection device to the second one-way valve of the valve system, the sleeve being configured to accommodate the sample collection device and configured to be coupled to the valve system, wherein:
the valve system is configured to be coupled to the ventilator outlet line,
the sample collection system is configured to allow the flow of gas into the sample collection system to occur during the periodic inspiration pulses of the inspiration cycle of the ventilator,
the sample collection system is configured to allow the flow of gas out of the sample collection system to occur between the inspiration pulses of the inspiration cycle of the ventilator,
the flow of gas into the sample collection system is actuated by the pump of the ventilator that is coupled to the sample collection system by way of the ventilator outlet line,
the flow of gas out of the sample collection system is facilitated by an outlet valve of the ventilator, and
a distance between the one or more sorbents and the opening of the cavity of the sample collection system is less than a distance between the port and the opening of the cavity of the sample collection system.
8. The ventilator system of claim 7 , further comprising:
a reservoir fluidly coupled to the first one-way valve of the valve system and the opening of the cavity of the sample collection device.
9. The ventilator system of claim 8 , wherein the sample collection system is further configured to:
allow the flow of gas into the reservoir during the inspiration pulses; and
allow the flow of gas out of the reservoir and into the sample collection device between the inspiration pulses.
10. The ventilator system of claim 7 , wherein the sample collection system does not include a pump other than the pump of the ventilator.
11. The ventilator system of claim 7 , wherein the gas is exhaled air.
12. The ventilator system of claim 7 , further comprising a sampling indicator, wherein the sampling indicator is one of a balloon, a diaphragm, a switch, a pressure gauge, or a pressure sensor.
13. A method comprising:
increasing, with a pump of a ventilator that is fluidly coupled to an outlet line of the ventilator, pressure in the outlet line of the ventilator during periodic inspiration pulses of an inspiration cycle of the ventilator;
during the periodic inspiration pulses of the inspiration cycle of the ventilator, actuating, with the pump of the ventilator, [[the]] flow of gas into a sample collection system; and
between the periodic inspiration pulses of the inspiration cycle of the ventilator, facilitating, with an outlet valve of the ventilator, the flow of gas out of the sample collection system, wherein:
the sample collection system is fluidly coupled to a valve system,
the valve system is fluidly coupled to the outlet line of the ventilator,
the sample collection system comprises a sample extraction device having a cavity containing one or more sorbents, and
the valve system comprises a first one-way valve that allows flow of gas into the sample collection system and a second one-way valve that allows flow of gas out of the sample collection system.
14. The method of claim 13 , wherein:
the sample collection system further comprises a sleeve having a volume, wherein the sleeve is configured to accommodate the sample collection device and configured to be coupled to the valve system.
15. The method of claim 14 , wherein:
the volume of the sleeve includes a fluid conveyance from a port of the sample collection device to the second one-way valve of the valve system, wherein:
a distance between the one or more sorbents and an opening of the cavity of the sample collection system is less than a distance between the port and the opening of the cavity of the sample collection system.
16. The method of claim 13 , wherein:
the sample collection system further comprises a reservoir fluidly coupled to the first one-way valve of the valve system and an opening of the cavity of the sample collection device.
17. The method of claim 13 , wherein the sample collection system configured to:
allow the flow of gas into a reservoir of the sample collection system during the inspiration pulses; and
allow the flow of gas out of the reservoir and into the sample collection device between the inspiration pulses.
18. The method of claim 13 , wherein the sample collection system does not include a pump other than the pump of the ventilator.
19. The method of claim 13 , wherein the gas is exhaled air.
20. The method of claim 13 , further comprising:
indicating, with a sampling indicator, a change in pressure in the sample collection system, wherein the sampling indicator is one of a balloon, a diaphragm, a switch, a pressure gauge, or a pressure sensor.