Palatable antiparasitic formulations
The present invention is directed to a palatable, hard chewable composition comprising a therapeutically effective amount of a veterinary acceptable isoxazoline, a stabilized macrocyclic lactone, an acceptable salt form of pyrantel, at least one natural animal based palatant, and at least one veterinary acceptable excipient; and methods for treating or preventing a parasitic infection or infestation in an animal in need thereof with said composition.
1. A palatable, hard chewable tablet veterinary composition comprising:
a. a therapeutically effective amount of sarolaner;
b. stabilized moxidectin wherein the moxidectin is stabilized with hydroxypropylmethyl cellulose and meglumine;
c. pyrantel pamoate;
d. at least one natural animal meat based palatant;
e. at least one veterinary acceptable excipient; and
f. optionally, at least one additional veterinary antiparasitic agent.
2. The composition of claim 1 , wherein the hydroxypropylmethyl cellulose and meglumine are in the amount of about 2 to about 3 w/w % of the total weight of the tablet.
3. The composition of claim 1 , wherein the moxidectin is further stabilized with an antioxidant.
4. The composition of claim 3 , wherein the sarolaner is in the amount of about 1.3 w/w %; the stabilized moxidectin is in the amount of about 0.03 w/w %, the pyrantel pamoate is in the amount of about 16 w/w %, and the natural animal meat based palatant is admixed with at least one other natural based palatant; and wherein the w/w % amounts are based on the total weight of the tablet.
5. A method of treating or preventing a parasitic infection or infestation in an animal in need thereof, by administering a palatable, hard chewable tablet veterinary composition comprising:
a. a therapeutically effective amount of sarolaner;
b. stabilized moxidectin wherein the moxidectin is stabilized with hydroxypropylmethyl cellulose and meglumine;
c. pyrantel pamoate;
d. at least one natural animal meat based palatant;
e. at least one veterinary acceptable excipient; and
f. optionally, at least one additional veterinary antiparasitic agent.
6. The method of claim 5 wherein the hydroxypropylmethyl cellulose and meglumine are in the amount of about 2 w/w % to about 3 w/w % of the total weight of the tablet.
7. The method of claim 6 wherein the animal is a companion animal.
8. The method of claim 7 wherein the companion animal is canine.
9. A palatable, hard chewable tablet veterinary composition comprising:
a. a therapeutically effective amount of sarolaner;
b. stabilized moxidectin and wherein the moxidectin is stabilized with hydroxypropylmethyl cellulose and meglumine;
c. pyrantel pamoate;
d. at least one natural animal meat based palatant;
e. at least one veterinary acceptable excipient; and
f. optionally, at least one additional veterinary antiparasitic agent, for the treatment or prevention of a parasitic infection or infestation in an animal.
10. The composition of claim 9 wherein the hydroxypropylmethyl cellulose and meglumine are in the amount of about 2 to about 3 w/w % of the total weight of the tablet.
11. The composition of claim 10 , wherein the sarolaner is in the amount of about 1.3 w/w %; the stabilized moxidectin is in the amount of about the pyrantel pamoate is in the amount of about 16 w/w %, and the natural animal meat based palatant is admixed with at least one other natural based palatant; and wherein the w/w % amounts are based on the total weight of the tablet.
12. The composition of claim 11 , wherein the palatant admixture comprises about 40 to 45% of the total weight of the tablet.