Pro-healing, pro-regenerative nanofibrous coating for medical implants
The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, the at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate.
1. A medical implant with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative,
wherein said hydrophobic, degradable core comprises a poly L-lactide acid (PLLA) core,
wherein said at least one polyethylene-glycol derivative of said coaxial sheath comprises polyethylene-glycol dimethacrylate (PEGDMA),
wherein said coating comprises a hybrid fiber coating,
wherein said medical implant comprises a vascular stent.
2. The medical implant of claim 1 , wherein said coating further comprises a controlled release agent.
3. The medical implant of claim 1 , wherein said coating further comprises a therapeutic agent.
4. The medical implant of claim 3 , wherein said therapeutic agent comprises an anti-proliferation agent.
5. The medical implant of claim 1 , wherein said hydrophobic, degradable core provides controlled drug release.
6. The medical implant of claim 1 , wherein said sheath integrates a surface signaling mechanism.
7. The medical implant of claim 6 , wherein said surface signaling mechanism is configured to simultaneously aid in regeneration.
8. The medical implant of claim 1 , wherein said coating further comprises sub-millimeter scale fibers.
9. The medical implant of claim 8 , wherein said sub-millimeter scale fibers provide a uniform surface.
10. The medical implant of claim 1 , wherein said coating has no delamination.
11. The medical implant of claim 1 , wherein said coating has an elastic modulus ranging from 100 to 1000 kPa.