Chitosan film with ternary metal oxides
A chitosan film including ternary metal oxides. In an embodiment, the ternary metal oxides can include tungsten oxide nanoparticles (WO 3 NPs), magnesium oxide nanoparticles (MgO NPs), and a graphene oxide (GO) layer. In an embodiment the chitosan film is porous. The chitosan film including ternary metal oxides can be used as a wound dressing for the clinical management of bacterially infected wounds.
1. A method of healing a wound in a patient comprising applying to a patient in need thereof a wound dressing material comprising a chitosan composite film at a site of the wound in the patient; the chitosan composite film comprising:
a polymeric matrix including chitosan; and
a plurality of ternary metal oxides comprising tungsten oxide nanoparticles (WO 3 NPs), magnesium oxide nanoparticles (MgO NPs), and graphene oxide (GO) incorporated in or on the polymeric matrix.
2. A method of healing a wound in a patient comprising applying to a patient in need thereof a wound dressing material comprising a chitosan composite film at a site of the wound in the patient; the chitosan composite film comprising:
a polymeric matrix including chitosan; and
a plurality of ternary metal oxides including tungsten oxide nanoparticles (WO 3 NPs) embedded within the polymeric matrix, magnesium oxide nanoparticles (MgO NPs) disposed on a surface of the polymeric matrix, and a graphene oxide (GO) layer on the polymeric matrix.
3. A method of healing a wound in a patient comprising applying to a patient in need thereof a wound dressing material comprising a chitosan composite film at a site of the wound in the patient; the chitosan composite film comprising:
a polymeric matrix including chitosan; and
a plurality of ternary metal oxides including tungsten oxide nanoparticles (WO 3 NPs) having an average diameter ranging from about 80 nm to about 100 nm, magnesium oxide nanoparticles (MgO NPs) having an average diameter ranging from about 40 nm to about 50 nm, and a graphene oxide (GO) layer on the polymeric matrix.
4. The method of healing of claim 1 , wherein the chitosan composite film is porous.
5. The method of healing of claim 1 , wherein at least some of the MgO NPs are disposed on a surface of the polymeric matrix.
6. The method of healing of claim 1 , wherein the WO 3 NPs are embedded within the polymeric matrix.
7. The method of healing of claim 1 , wherein the MgO nanoparticles have an average diameter ranging from about 40 nm to about 50 nm.
8. The method of healing of claim 1 , wherein the WO 3 NPs have an average diameter ranging from about 80 nm to about 100 nm.
9. The method of healing of claim 2 , wherein the MgO nanoparticles have an average diameter ranging from about 40 nm to about 50 nm.
10. The method of healing of claim 2 , the WO 3 NPs have an average diameter ranging from about 80 nm to about 100 nm.
11. The method of healing of claim 3 , wherein the tungsten oxide nanoparticles (WO 3 NPs) are embedded within the polymeric matrix.
12. The method of healing of claim 3 , wherein the magnesium oxide nanoparticles (MgO NPs) are disposed on a surface of the polymeric matrix.