Digital tissue segmentation and viewing

1. A method of computationally representing a tissue segmentation image from a source digital image, the method comprising the steps of:

at a remote computer, computationally generating, from a source digital image of an anatomic region, a digital tissue segmentation image visually indicating regions of interest corresponding to a physiologic condition associated with at least portions of the anatomic region;

storing, at a server, a plurality of versions of the source image each having a different resolution from the other versions; and

on a mobile device, (i) alternately displaying each of the source image and the tissue segmentation image or corresponding portions thereof in registration at a gesturally selected magnification level and at a first resolution level, (ii) responsive to a higher gesturally selected magnification, providing from the server a corresponding portion of a higher-resolution version of the displayed image stored on the server, and (iii) replacing the displayed image with the provided corresponding portion.

2. The method of claim 1 , further comprising receiving, at the server, coordinates from the mobile device specifying a displayed portion of the source image or the tissue segmentation image at the gesturally selected magnification and responsively making a corresponding portion of the higher-resolution source image version available to the mobile device.

3. The method of claim 2 , wherein the plurality of higher-resolution image versions are each represented at the server by a plurality of tiles having a tile count determined by an image resolution, the corresponding portion of the higher-resolution source image version obtained from the server comprising tiles.

4. The method of claim 2 , wherein the plurality of higher-resolution source image versions are each represented at the server as unitary images, the corresponding portion of the higher-resolution source image version obtained from the server being a single image.

5. The method of claim 4 , wherein the plurality of higher-resolution source images are related to each other by at least one geometric transformation.

6. The method of claim 1 , further comprising, at the server:

computationally generating the digital tissue segmentation from the source digital image at a selected one of the resolutions;

applying the digital tissue segmentation to the source image at the other resolutions; and

responsive to an increase in magnification of a displayed digital tissue segmentation on the mobile device, replacing the displayed digital tissue segmentation with corresponding subject matter from one of the higher-resolution representations thereof.

7. The method of claim 1 , wherein the digital tissue segmentation includes a plurality of overlays designating, and colorwise distinguishing, high-precision regions of interest and high-recall regions of interest superimposed on corresponding regions of the digital source image.

8. The method of claim 1 , further comprising computationally analyzing one or more of the regions of interest to identify a subtype associated therewith.

9. The method of claim 8 , wherein the subtype is a cancer subtype.

10. The method of claim 8 , wherein the subtype is a cancer severity level.

11. The method of claim 1 , wherein the digital tissue segmentation image is an overlay.

12. A system comprising:

a remote computer configured to computationally generate, from a source digital image of an anatomic region, a digital tissue segmentation image visually indicating regions of interest corresponding to a physiologic condition associated with at least portions of the anatomic region;

a server;

a storage device for storing, accessible to the server, a plurality of versions of the source image each having a different resolution from the other versions; and

a mobile device configured to (i) alternately display each of the source image and the tissue segmentation image or corresponding portions thereof in registration at a gesturally selected magnification level and at a first resolution level, (ii) responsive to a higher gesturally selected magnification, obtain from the server a corresponding portion of a higher-resolution version of the displayed image stored on the storage device, and (iii) replace the displayed image with the provided corresponding portion.

13. The system of claim 12 , wherein the server is configured to (i) receive coordinates from the mobile device specifying a displayed portion of the source image or the tissue segmentation image at the gesturally selected magnification and (ii) responsively make a corresponding portion of the higher-resolution source image version available to the mobile device.

14. The system of claim 13 , wherein the plurality of higher-resolution image versions are each represented on the storage device by a plurality of tiles having a tile count determined by an image resolution, the corresponding portion of the higher-resolution source image version obtained from the server comprising tiles.

15. The system of claim 13 , wherein the plurality of higher-resolution source image versions are each represented on the storage device as unitary images, the corresponding portion of the higher-resolution source image version obtained from the server being a single image.

16. The system of claim 15 , wherein the plurality of higher-resolution source images are related to each other by at least one geometric transformation.

17. The system of claim 12 , wherein the server is configured to computationally generate the digital tissue segmentation from the source digital image at a selected one of the resolutions; apply the digital tissue segmentation to the source image at the other resolutions; and responsive to an increase in magnification of a displayed digital tissue segmentation on the mobile device, cause the displayed digital tissue segmentation to be replaced with corresponding subject matter from one of the higher-resolution representations thereof.

18. The system of claim 12 , wherein the digital tissue segmentation includes a plurality of overlays designating, and colorwise distinguishing, high-precision regions of interest and high-recall regions of interest superimposed on corresponding regions of the digital source image.

19. The system of claim 12 , wherein the source digital image and the digital tissue segmentation image have substantially identical dimensions.

20. The system of claim 12 , wherein the digital tissue segmentation image is an overlay.