3-cyano 4,5-diphenyl furan-2-carboxamides as antitubercular agents
Compounds for treating a microbial infection and/or tuberculosis and, particularly, antimicrobial and/or antitubercular compounds that are 3-cyano 4,5-diphenyl furan-2-carboxamides and their use as antimicrobial and/or antitubercular agents are provided.
1. A pharmaceutical composition comprising a compound and a pharmaceutically acceptable carrier, wherein the compound has the formula I;
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R 1 is —SO 2 —; and
R 2 is methyl, phenyl, 4-chlorophenyl, or 4-methylphenyl.
2. A method of treating a microbial infection in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the formula I;
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R 1 is —SO 2 —; and
R 2 is methyl, phenyl, 4-chlorophenyl, or 4-methylphenyl.
3. The method of claim 2 , wherein the microbial infection is caused by strains of Mycobacterium smegmatis.
4. The method of claim 2 , wherein the microbial infection is tuberculosis caused by H37Rv strains of Mycobacterium tuberculosis.