Methods of preventing cancer metastasis
A method of preventing metastasis of a cancer in a patient in need thereof includes administering to the patient a therapeutically effective amount of ibudilast, or a pharmaceutical salt thereof.
1. A method of preventing, ameliorating, or minimizing metastasis of eye cancer in a patient in need thereof, the method comprising:
administering to the patient a therapeutically effective amount of ibudilast, or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the eye cancer is uveal melanoma.
3. The method of claim 1 , wherein ibudilast, or the pharmaceutically acceptable salt thereof, is administered for at least 3 months.
4. The method of claim 1 , wherein ibudilast, or the pharmaceutically acceptable salt thereof, is administered for at least six months.
5. The method of claim 1 , wherein ibudilast, or the pharmaceutically acceptable salt thereof, is administered for at least one year.
6. The method of claim 1 , wherein ibudilast, or the pharmaceutically acceptable salt thereof, is administered for at least two years.
7. The method of claim 1 , wherein ibudilast, or the pharmaceutically acceptable salt thereof, is administered at least once daily.
8. The method of claim 1 , wherein ibudilast, or the pharmaceutically acceptable salt thereof, is administered orally.
9. The method of claim 1 , wherein the therapeutically effective amount of ibudilast, or the pharmaceutically acceptable salt thereof, is from 0.1 mg to 720 mg per day.
10. The method of claim 1 , wherein the therapeutically effective amount of ibudilast, or the pharmaceutically acceptable salt thereof, is at least 30 mg/day.
11. The method of claim 1 , wherein the therapeutically effective amount of ibudilast, or the pharmaceutically acceptable salt thereof, is from 30 mg to 200 mg per day.
12. The method of claim 1 , wherein the therapeutically effective amount of ibudilast, or the pharmaceutically acceptable salt thereof, is 60 mg to 600 mg daily.
13. The method of claim 1 , wherein the therapeutically effective amount of ibudilast, or the pharmaceutically acceptable salt thereof, is 100 mg to 480 mg daily.
14. The method of claim 1 , wherein the therapeutically effective amount of ibudilast, or the pharmaceutically acceptable salt thereof, is selected from the group consisting of 30 mg/day, 60 mg/day, 90 mg/day, 100 mg/day, 120 mg/day, 150 mg/day, 180 mg/day, 210 mg/day, 240 mg/day, 270 mg/day, 300 mg/day, 360 mg/day, 400 mg/day, 440 mg/day, 480 mg/day, 520 mg/day, 580 mg/day, 600 mg/day, 620 mg/day, 640 mg/day, 680 mg/day, and 720 mg/day.
15. The method of claim 1 , wherein the therapeutically effective amount is administered as a single dose or is divided into two, three, or four doses.
16. The method of claim 1 , wherein ibudilast is administered continually.