Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
The invention provides an oral solid formulation comprising (a) a controlled release component comprising a core comprising levodopa, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric polymer; and (b) an immediate release component comprising levodopa.
1. A multiparticulate controlled release oral solid formulation comprising a plurality of controlled release particles wherein the controlled release particles comprise:
a) a core comprising levodopa, esters or salts thereof,
b) a rate controlling coating surrounding the core,
c) a mucoadhesive coating surrounding the rate controlling coating, and
wherein the core is a pellet, a bead, or a granule; the formulation comprises from about 90 to 500 mg of levodopa, esters or salts thereof; and the core is free of decarboxylase inhibitor.
2. The controlled release oral solid formulation of claim 1 , wherein the rate controlling coating comprises a rate controlling polymer selected from the group consisting of cellulose acetate, ethyl cellulose, and a mixture thereof.
3. The controlled release formulation of claim 1 , wherein the mucoadhesive coating comprises a cationic mucoadhesive polymer.
4. The controlled release formulation of claim 3 , wherein the cationic mucoadhesive polymer is an amino methacrylate copolymer.
5. The controlled release formulation of claim 4 , wherein the amino methacrylate copolymer is poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate).
6. The controlled release formulation of claim 3 , wherein the muco-adhesive coating further comprises a polymer selected from the group consisting of polycarbophil, carbomer, cellulosics, chitosan, diethylaminodextran, diethylaminoethyldextran, polygalactosamine, polylysine, polyomithine, prolamine, polyimine, hyaluronic acid, sodium alginate, sodium carboxymethylcellulose (sodium CMC), and alginate, or a combination thereof.
7. The controlled release oral solid formulation of claim 1 , wherein the core is a spheronized bead.
8. The controlled release oral solid formulation of claim 7 , wherein the spheronized bead has a size of between 0.8 to 1.2 mm.
9. The controlled release oral solid formulation of claim 7 , wherein the spheronized bead coated with a rate controlling coating and the mucoadhesive coating passes through a mesh screen size of 16 or less and is retained on a mesh screen size of at least 18.
10. The controlled release oral solid formulation of claim 1 , wherein the formulation further comprises an immediate release component comprising levodopa, esters or salts thereof; and carbidopa, esters or salts thereof.
11. A controlled release oral solid formulation comprising
a) a controlled release component comprising a core comprising levodopa, ester or salt thereof, wherein the core is free of a decarboxylase inhibitor and is coated with a muco-adhesive polymer coating; and
b) an immediate release component comprising levodopa, an ester or salt thereof, wherein the core is a pellet, a bead, or a granule and the formulation comprises from about 90 mg to about 500 mg of levodopa, esters or salts thereof.
12. The controlled release oral solid formulation of claim 11 further comprising a rate-controlling polymer coating which undercoats the muco-adhesive polymer coating within the controlled release component.
13. The controlled release formulation of claim 12 , wherein the rate controlling polymer coating comprises a polymer selected from the group consisting of cellulose acetate, ethyl cellulose, and a mixture thereof.
14. The controlled release formulation of claim 11 , wherein the mucoadhesive polymer coating comprises a cationic polymer.
15. The controlled release formulation of claim 14 , wherein the cationic polymer is an amino methacrylate copolymer.
16. The controlled release formulation of claim 15 , wherein the amino methacrylate copolymer is poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate).
17. The controlled release oral solid formulation of claim 11 wherein the immediate release component further comprises carbidopa.
18. The controlled release formulation of claim 11 , wherein the controlled release component releases less than 20% of the levodopa within two hours, measured using a United States Pharmacopeia (USP) Type I apparatus at 75 rpm, in about 900 ml of a dissolution medium at pH of about 1.
19. The controlled release formulation of claim 17 , wherein the formulation releases from about 75% to about 100% of the carbidopa in 30 minutes or less, measured using United States Pharmacopeia (USP) Type I or Type II apparatus, in about 500-900 mL of an aqueous medium with a pH from about 1 to about 7.5.
20. A multiparticulate controlled release oral solid formulation comprising a plurality of controlled release particles wherein the controlled release particles comprise:
a) a core comprising levodopa, esters or salts thereof,
b) a rate controlling coating surrounding the core, and
c) a mucoadhesive coating surrounding the rate controlling coating,
wherein the core is a pellet, a bead, or a granule; the formulation comprises from about 90 mg to about 500 mg of levodopa, esters or salts thereof; wherein the core is free of decarboxylase inhibitor, and the formulation provides an in vivo levodopa plasma profile following oral administration of the controlled release oral solid formulation to a subject under fasting conditions comprising:
(a) a time of administration;
(b) a levodopa plasma concentration corresponding to maximum levodopa plasma concentration (Cmax) occurring within 6 hours after administration of the dosage form;
(c) a time to reach 50% Cmax of less than one hour; and
(d) wherein the in vivo plasma level of levodopa is maintained at 50% Cmax or above for at least 3 hours.