Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
Disclosed herein are methods of treating conditions, which may be associated with elevated levels of eosinophils and/or basophils, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.
1. A method of treating a condition characterized by increased numbers of eosinophils in a subject comprising:
administering to a subject in need thereof a therapeutically effective amount of R(+) pramipexole, or a pharmaceutically acceptable salt thereof, wherein the condition is a gastrointestinal disease.
2. The method of claim 1 , wherein the condition is characterized by eosinophil numbers above about 100 cells per microliter in the peripheral blood.
3. The method of claim 1 , wherein the therapeutically effective amount of R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is from about 50 mg to about 1,500 mg per day.
4. The method of claim 1 , wherein the therapeutically effective amount of R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is from about 150 mg to about 1,500 mg per day.
5. The method of claim 1 , wherein the therapeutically effective amount of R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is from about 150 mg to about 300 mg per day.
6. The method of claim 1 , wherein the therapeutically effective amount of R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is about 150 mg per day.
7. The method of claim 1 , wherein the therapeutically effective amount of R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is about 300 mg per day.
8. The method of claim 1 , wherein R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is administered two or more times per day.
9. The method of claim 1 , wherein R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is administered at a fraction of a daily dose two or more times per day.
10. The method of claim 8 , wherein R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is administered two times per day.
11. The method of claim 10 , wherein the dose is administered every 12 hours.
12. The method of claim 1 , wherein R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is administered at about 150 mg two times per day.
13. The method of claim 1 , further comprising administering a second therapeutic agent that is capable of decreasing eosinophil levels, the agent selected from the group consisting of a glucocorticoid, a corticosteroid, a non-steroidal anti-inflammatory drug (NSAID), a tyrosine kinase inhibitor, a fusion protein, a monoclonal antibody directed against one or more pro-inflammatory cytokines, a chemotherapeutic agent and a combination thereof.
14. The method of claim 1 , wherein R(+) pramipexole, or a pharmaceutically acceptable salt thereof, is administered orally.