N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl] pyridine-3-carboxamide as an eco-friendly insecticidal agent against
Synthesis of a compound N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide and its use as an insecticidal agent.
1. A method of making a N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound, the method comprising:
adding sodium hydroxide to a cyanoguanidine solution and an acetylacetone solution to obtain a first reaction mixture;
stirring the first reaction mixture with reflux;
recrystallizing a resulting (4,6-dimethylpyrimidin-2-yl)cyanamide from ethanol;
passing H 2 S gas into a solution of (4,6-dimethylpyrimidin-2-yl)cyanamide in ethanol and adding triethylamine to obtain 1-(4,6-dimethylpyrimidin-2-yl)thiourea;
dissolving the 1-(4,6-dimethylpyrimidin-2-yl)thiourea in a solution of ethanol and sodium metal, then adding ethyl-3-pyridine carboxylate to obtain a second reaction mixture;
refluxing the second reaction mixture; obtaining a white solid from the second reaction mixture;
recrystallizing a white solid using ethanol; and
obtaining the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound.
2. The method of making the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound of claim 1 , wherein the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound is obtained as white crystals.
3. The method of making the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound of claim 1 , wherein the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound is obtained in an about 41% yield.
4. The method of making the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound of claim 1 , wherein the first reaction mixture is refluxed for at least about 8 hours.
5. The method of making the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound of claim 1 , wherein the second reaction mixture is refluxed for at least about 5 hours.
6. The method of making the N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound of claim 1 , wherein the dissolving 1-(4,6-dimethylpyrimidin-2-yl)thiourea in a solution of ethanol and sodium metal lasts for about 2 hours.