Substituted indole and indazole compounds

1. A compound of Formula (I)

N-oxide, or a salt thereof, wherein:

X is CR 1 or N;

each R 1 is independently H, F, Cl, —CN, C 1-3 alkyl, C 1-2 fluoroalkyl, —OCH 3 , or —S(O) 2 (C 1-3 alkyl);

G is

a 9-membered heterocyclic ring selected from:

each R 2 is independently F, Cl, —CN, —OH, C 1-3 alkyl, C 1-2 fluoroalkyl, C 1-2 cyanoalkyl, C 1-3 hydroxyalkyl, C 1-2 aminoalkyl, —(CH 2 ) 0-2 O(C 1-3 alkyl), C 3-6 cycloalkyl, —NR x R x , —(CH 2 ) 0-2 C(O)NR x R x , —(CH 2 ) 0-2 S(O) 2 (C 1-3 alkyl), —CH 2 (C 3-6 cycloalkyl), —CH 2 (phenyl), phenyl, pyrimidinyl, or triazolyl;

A is:

(i) —OCH 2 CH 2 NR y R y ;

(ii) —CR x R x R 3 , —CH 2 CH 2 NR x R 3 , —C(O)NR x R 3 , —NR x R 3 , —NR x CH 2 CH 2 R 3 , or —OR 3 ; or

(iii) R 3 ;

R 3 is C 3-6 cycloalkyl, azetidinyl, morpholinyl, piperazinyl, piperidinyl, or pyrrolidinyl, each substituted with zero to 2 R 3a ;

each R 3a is independently C 1-4 alkyl, C 1-3 cyanoalkyl, C 1-3 fluoroalkyl, C 1-4 hydroxyalkyl, —CH 2 C(O)NR x R x , —C(O)(CH 2 ) 1-3 NR x R x , —NR y R y , (CH 2 ) 1-2 S(O) 2 (C 1-2 alkyl), —(CH 2 ) 1-2 NR x S(O) 2 (C 1-2 alkyl), —NR x CH 2 C(O)NR y R y , —NR x CH 2 CH 2 S(O) 2 (C 1-2 alkyl), —NR x (C 3-6 cycloalkyl), —NR x (oxetanyl), —CH 2 (methyltriazolyl), morpholinyl, oxetanyl, pyrrolidinyl, fluoropyrrolidinyl, hydroxy-methylpyrrolidinyl, tetrahydropyranyl, 1-oxa-6-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.4]octanyl, 6-oxa-2-azaspiro[3.4]octanyl, 2,2-dioxo-2-thia-6-azaspiro[3.3]heptanyl, 2-oxa-7-azaspiro[4.4]nonanyl, or azetidinyl substituted with zero to 3 substituents independently selected from F, Cl, —OH, —CN, C 1-2 alkyl, C 1-2 hydroxyalkyl, C 1-2 fluoroalkyl, and C 1-3 alkoxy;

each R x is independently H or —CH 3 ;

each R y is independently H or C 1-6 alkyl;

n is zero, 1, or 2; and

p is zero, 1, or 2.

2. The compound according to claim 1 , N-oxide, or a salt thereof,

wherein:

each R 1 is independently H, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —OCH 3 , or —S(O) 2 CH 3 ;

G is:

each R 2 is independently —CN, —CH 3 , —OCH 3 , or pyrimidinyl;

A is:

(i) —OCH 2 CH 2 N(CH 3 ) 2 ;

(ii) —CH 2 R 3 , —CH 2 CH 2 NHR 3 , —C(O)NHR 3 , —NHR 3 , —NHCH 2 CH 2 R 3 , or —OR 3 ; or

(iii) R 3 ;

R 3 is azetidinyl, cyclobutyl, cyclohexyl, piperazinyl, piperidinyl, or pyrrolidinyl, each substituted with zero to 1 R 3a ;

R 3a is —CH 3 , —CH 2 CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 CN, —CH 2 CH 2 CN, —CH 2 CH 2 CF 3 , —CH 2 C(CH 3 ) 2 OH, —CH 2 C(O)NH 2 , —CH 2 C(O)N(CH 3 ) 2 , —C(O)CH 2 N(CH 3 ) 2 , —C(O)CH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 2 CH 2 CH 2 N(CH 3 ) 2 , —NH(CH 3 ), —N(CH 3 ) 2 , —NH(CH(CH 3 ) 2 ), —CH 2 CH 2 S(O) 2 CH 3 , —CH 2 CH 2 NHS(O) 2 CH 3 , —NHCH 2 C(O)N(CH 3 ) 2 , —NHCH 2 CH 2 S(O) 2 CH 3 , —NH(cyclopropyl), —NH(oxetanyl), —N(CH 3 ) (oxetanyl), —CH 2 (methyltriazolyl), morpholinyl, oxetanyl, pyrrolidinyl, fluoropyrrolidinyl, hydroxy-methylpyrrolidinyl, tetrahydropyranyl, 1-oxa-6-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.4]octanyl, 6-oxa-2-azaspiro[3.4]octanyl, 2,2-dioxo-2-thia-6-azaspiro[3.3]heptanyl, 2-oxa-7-azaspiro[4.4]nonanyl, or azetidinyl substituted with zero to 2 substituents independently selected from F, —OH, —CH 3 , —CH 2 OH, —OCH 3 , —OCH 2 CH 3 , and —OCH(CH 3 ) 2 ;

n is zero or 1; and

p is zero, 1, or 2.

3. The compound according to claim 1 , N-oxide, or a salt thereof, wherein:

each R 1 is independently H, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —OCH 3 , or —S(O) 2 CH 3 ;

G is:

each R 2 is independently —CN, —CH 3 , —OCH 3 , or pyrimidinyl;

A is:

(i) —CH 2 R 3 , —CH 2 CH 2 NHR 3 , —C(O)NHR 3 , —NHR 3 , —NHCH 2 CH 2 R 3 , or —OR 3 ; or

(ii) R 3 ;

R 3 is azetidinyl, cyclobutyl, cyclohexyl, piperazinyl, piperidinyl, or pyrrolidinyl, each substituted with zero to 1 R 3a ;

R 3a is —CH 3 , —CH 2 CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 CN, —CH 2 CH 2 CN, —CH 2 CH 2 CF 3 , —CH 2 C(CH 3 ) 2 OH, —CH 2 C(O)NH 2 , —CH 2 C(O)N(CH 3 ) 2 , —C(O)CH 2 N(CH 3 ) 2 , —C(O)CH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 2 CH 2 CH 2 N(CH 3 ) 2 , —NH(CH 3 ), —N(CH 3 ) 2 , —NH(CH(CH 3 ) 2 ), —CH 2 CH 2 S(O) 2 CH 3 , —CH 2 CH 2 NHS(O) 2 CH 3 , —NHCH 2 C(O)N(CH 3 ) 2 , —NH(CH 2 CH 2 S(O) 2 CH 3 ), —NH(cyclopropyl), —NH(oxetanyl), —N(CH 3 )(oxetanyl), —CH 2 (methyltriazolyl), morpholinyl, oxetanyl, pyrrolidinyl, fluoropyrrolidinyl, hydroxy-methylpyrrolidinyl, tetrahydropyranyl, 1-oxa-6-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.4]octanyl, 6-oxa-2-azaspiro[3.4]octanyl, 2,2-dioxo-2-thia-6-azaspiro[3.3]heptanyl, 2-oxa-7-azaspiro[4.4]nonanyl, or azetidinyl substituted with zero to 2 substituents independently selected from F, —OH, —CH 3 , —CH 2 OH, —OCH 3 , —OCH 2 CH 3 , and —OCH(CH 3 ) 2 ;

n is zero or 1; and

p is zero, 1, or 2.

4. The compound according to claim 1 , N-oxide, or a salt thereof, wherein X is N.

5. The compound according to claim 1 or a salt thereof, wherein

X is CH or N;

G is:

R 2 is —CH 3 or —OCH 3 ;

A is: —OR 3 or R 3 ;

R 3 is cyclobutyl, cyclohexyl, piperazinyl, piperidinyl, or pyrrolidinyl, each substituted with zero to 1 R 3a ;

n is zero or 1; and

p is zero or 1.

6. The compound according to claim 1 or a salt thereof, wherein

X is N;

G is:

R 2 is —CH 3 or —OCH 3 .

7. The compound according to claim 1 , N-oxide, or a salt thereof, wherein said compound is:

8-methyl-6-(5-methyl-3-(piperidin-4-yl)-1H-indol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (1);

8-methyl-6-(4-methyl-3-(piperidin-4-yl)-1H-indol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (2);

N,N-dimethyl-4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)cyclohexan-1-amine (3-4);

2-(dimethylamino)-1-(3-(4-methyl-6-(8-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (5);

N,N-dimethyl-3-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclobutan-1-amine (6-7);

2-(4-(4-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl)-N,N-dimethylacetamide (8);

6-(5-isopropyl-3-(1-propylpiperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (9);

8-methyl-6-(5-methyl-3-(piperidin-4-ylmethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (10);

8-methoxy-6-(3-(piperidin-4-yl)-1H-indol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (11);

8-methyl-6-(3-(piperidin-4-yl)-1H-indol-6-yl)-[1,2,4]triazolo[1,5-a] pyridine (12);

N-(2-(6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indol-3-yl) ethyl) piperidin-4-amine (13);

N,N-dimethyl-4-(6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-3-yl) cyclohexan-1-amine (14);

N,N-dimethyl-4-(6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-3-yl) cyclohexan-1-amine (15);

8-methyl-6-(4-methyl-3-(piperidin-4-yl)-1H-indol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (16);

8-methyl-6-(3-(piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (17);

8-methyl-6-(5-methyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (18);

6-(5-methoxy-3-(piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (19);

2-(dimethylamino)-1-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (20);

8-methyl-6-(5-methyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (21);

8-methyl-6-(5-methyl-3-(1-propylpiperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (22);

N,N-dimethyl-2-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (23);

8-methyl-6-(5-methyl-3-(piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (24);

8-methyl-6-(5-methyl-3-(pyrrolidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (26);

8-methyl-6-(4-methyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a] pyridine (27);

N,N-dimethyl-2-((4-(5-methyl-6-(8-methyl-[1,2,4] triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) amino) acetamide (28);

N,N-dimethyl-2-((4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) amino) acetamide (29);

4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N-(2-(methylsulfonyl) ethyl) cyclohexan-1-amine (30);

4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N-(2-(methylsulfonyl) ethyl) cyclohexan-1-amine (31);

N-methyl-N-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) oxetan-3-amine (32);

N-methyl-N-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) oxetan-3-amine (33);

N-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) oxetan-3-amine (34);

N-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) oxetan-3-amine (35);

N-cyclopropyl-4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (36);

N-cyclopropyl-4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (37);

N-isopropyl-4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (38);

N-isopropyl-4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (39);

2-(dimethylamino)-1-(3-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (40);

N,N-dimethyl-2-(3-(5-methyl-6-(8-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (41);

8-methyl-6-(5-methyl-3-(1-(oxetan-3-yl) piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (42);

8-methyl-6-(5-methyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (43);

N-methyl-4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (44);

8-methoxy-6-(5-methyl-3-(piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (45);

5-methyl-6-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-(piperidin-3-yl)-1H-indazole (47);

7,8-dimethyl-6-(5-methyl-3-(piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (48);

6-(3-(azetidin-3-yl)-5-methyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (49);

8-methyl-6-(4-methyl-3-(piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (51);

8-methyl-6-(5-methyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo [1,5-a] pyridine (52);

N,N-dimethyl-2-(3-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (53);

2-(dimethylamino)-1-(3-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (54);

8-methyl-6-(5-methyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (55);

2-(dimethylamino)-1-(3-(5-methyl-6-(8-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (56);

N,N-dimethyl-2-(3-(5-methyl-6-(8-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (57);

6-(5-methyl-3-(piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a] pyridine (58);

N,N-dimethyl-2-(3-(4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (59);

8-methyl-6-(4-methyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (60);

8-methyl-6-(4-methyl-3-(1-methylpiperidin-3-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (61);

8-methyl-6-(5-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (63);

8-methoxy-6-(5-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (64);

8-methyl-6-(4-methyl-1H-indazol-6-yl)-[1,2,4] triazolo[1,5-a]pyridine (65);

8-methoxy-6-(4-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a] pyridine (66);

2-methyl-1-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propan-2-ol (67);

8-methyl-6-(5-methyl-3-(1-(2-(methylsulfonyl) ethyl) piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (68);

N-(2-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethyl) methanesulfonamide (69);

2-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (70);

2-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetonitrile (71);

3-(4-(5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propanenitrile (72);

8-methyl-6-(5-methyl-3-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (73);

8-methyl-6-(5-methyl-3-(piperidin-4-yl)-1H-indazol-6-yl) tetrazolo[1,5-a]pyridine (74);

2-(dimethylamino)-1-(4-(4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (75);

N,N-dimethyl-2-(4-(4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (76);

2-methyl-1-(4-(4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propan-2-ol (77);

8-methyl-6-(4-methyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (78);

8-methyl-6-(4-methyl-3-(1-methylpiperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (79);

N,N-dimethyl-4-(4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (80);

N,N-dimethyl-4-(4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (81);

6-(5-ethyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (82);

5,8-dimethyl-6-(5-methyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4] triazolo[1,5-a] pyridine (83);

6-(5-methyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (84);

6-(5-methyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-8-(pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridine (85);

6-(4-methoxy-3-(piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (86);

2-(dimethylamino)-1-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (87);

6-(5-ethyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (88);

6-(5-ethyl-3-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (89);

6-(5-ethyl-3-(1-isopropylpiperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (90);

2-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl)-N,N-dimethylacetamide (91);

2-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetamide (92);

4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N,N-dimethylcyclohexan-1-amine (93-94);

2-((4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) amino)-N,N-dimethylacetamide (95-96);

N-cyclopropyl-4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (97-98);

4-(5-ethyl-6-(8-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N-(2-(methylsulfonyl) ethyl) cyclohexan-1-amine (99-100);

1-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl)-2-methylpropan-2-ol (101);

6-(5-isopropyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (102);

3-(dimethylamino)-1-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propan-1-one (103);

2-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) acetonitrile (104);

6-(5-ethyl-3-(1-((1-methyl-1H-1,2,3-triazol-4-yl) methyl) piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (105);

3-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propanenitrile (106);

4-(dimethylamino)-1-(4-(5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) butan-1-one (107);

6-(5-ethyl-3-(1-(3,3,3-trifluoropropyl) piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (108);

6-(4-ethyl-3-(piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (109);

2-(dimethylamino)-1-(4-(4-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (110);

2-(dimethylamino)-1-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (111);

2-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl)-N,N-dimethylacetamide (112);

1-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl)-2-methylpropan-2-ol (113);

4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N,N-dimethylcyclohexan-1-amine (114-115);

6-(5-isopropyl-3-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (116);

2-(dimethylamino)-1-(4-(5-isopropyl-6-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) ethan-1-one (117);

N-cyclopropyl-4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexan-1-amine (118-119);

6-(5-isopropyl-3-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (120);

3-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propanenitrile (121);

3-(dimethylamino)-1-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) piperidin-1-yl) propan-1-one (122);

6-(5-isopropyl-3-(1-isopropylpiperidin-4-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (123);

2-((4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) amino)-N,N-dimethylacetamide (124-125);

4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N-(2-(methylsulfonyl) ethyl) cyclohexan-1-amine (126-127);

6-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-2-oxa-6-azaspiro[3.3]heptane (128-129);

6-(5-isopropyl-3-(4-(pyrrolidin-1-yl) cyclohexyl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (130-131);

4-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) morpholine (132-133);

6-(3-(4-(3,3-difluoroazetidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a] pyridine (134-135);

6-(3-(4-(3,3-dimethylazetidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (136-137);

6-(3-(4-(azetidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (138-139);

4-(5-isopropyl-6-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl)-N,N-dimethylcyclohexan-1-amine (140-141);

6-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-2-thia-6-azaspiro[3.3] heptane 2,2-dioxide (142-143);

6-(5-isopropyl-3-(4-(3-methoxyazetidin-1-yl) cyclohexyl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (144-145);

(1-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl) azetidine-3,3-diyl) dimethanol (146);

6-(5-isopropyl-3-(4-(3-methoxyazetidin-1-yl) cyclohexyl)-1H-indazol-6-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine (147-148);

6-(3-(4-(3-ethoxyazetidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (149-150);

6-(3-(4-(3-fluoroazetidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4] triazolo[1,5-a]pyridine (151-152);

1-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-3-methylazetidin-3-ol (153-154);

6-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-1-oxa-6-azaspiro[3.3]heptane (155-156);

2-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-6-oxa-2-azaspiro[3.4]octane (157-158);

6-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-2-oxa-6-azaspiro[3.4]octane (159-160);

6-(3-(4-(3-isopropoxyazetidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (161-162);

6-(3-(4-(3-fluoropyrrolidin-1-yl) cyclohexyl)-5-isopropyl-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (163-164);

1-(4-(5-isopropyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-3-methylpyrrolidin-3-ol (165-166);

8-methyl-6-(5-methyl-3-(piperidin-4-yloxy)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (167);

4-((4-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy)-N,N-dimethylcyclohexan-1-amine (168-169);

2-(dimethylamino)-1-(4-((5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) oxy) piperidin-1-yl) ethan-1-one (170);

8-methyl-6-(5-methyl-3-((1-methylpiperidin-4-yl) oxy)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (171);

N,N-dimethyl-2-((5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) ethan-1-amine (172);

N,N-dimethyl-2-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) ethan-1-amine (173);

8-methyl-6-(4-methyl-3-(piperidin-4-yloxy)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (174);

2-(dimethylamino)-1-(4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) piperidin-1-yl) ethan-1-one (175);

N,N-dimethyl-2-(4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) piperidin-1-yl) acetamide (176);

8-methyl-6-(4-methyl-3-((1-methylpiperidin-4-yl) oxy)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (177);

8-methyl-6-(4-methyl-3-((1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl) oxy)-1H-indazol-6-yl)-[1,2,4] triazolo[1,5-a]pyridine (178);

N,N-dimethyl-4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) oxy) cyclohexan-1-amine (179-180);

N,N-dimethyl-4-((5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) cyclohexan-1-amine (181-182);

4-((6-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methyl-1H-indazol-3-yl) oxy)-N,N-dimethylcyclohexan-1-amine (183-184);

N,N-dimethyl-2-((4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) cyclohexyl) amino) acetamide (185-186);

4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy)-N-(2-(methylsulfonyl) ethyl) cyclohexan-1-amine (187-188);

N-cyclopropyl-4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) cyclohexan-1-amine (189-190);

4-((5-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy)-N,N-dimethylcyclohexan-1-amine (191-192);

8-methyl-6-(4-methyl-3-((1-((1-methyl-1H-1,2,3-triazol-4-yl) methyl) piperidin-4-yl) oxy)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (193);

2-(4-((4-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) piperidin-1-yl) acetonitrile (194);

6-(4-ethyl-3-(piperidin-4-yloxy)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (195);

2-(4-((4-ethyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-yl) oxy) piperidin-1-yl)-N,N-dimethylacetamide (196);

6-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(piperidin-4-yl)-1H-indole-3-carboxamide (197);

6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(piperidin-4-yl)-1H-indole-3-carboxamide (198);

6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide (199);

6-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-N-(piperidin-4-yl)-1H-indazol-3-amine (200);

5-methyl-6-(8-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-yl)-1H-indazol-3-amine (201);

5-methyl-6-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(2-(pyrrolidin-1-yl) ethyl)-1H-indazol-3-amine (204);

8-methyl-6-(5-methyl-3-(piperazin-1-yl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine (205);

6-(5-isopropyl-3-(piperazin-1-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (206);

6-(5-isopropyl-3-(piperazin-1-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (207);

6-(5-isopropyl-3-(4-isopropylpiperazin-1-yl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (208);

7-(4-(5-isopropyl-6-(8-methyl-[1,2,4] triazolo[1,5-a] pyridin-6-yl)-1H-indazol-3-yl) cyclohexyl)-2-oxa-7-azaspiro[4.4] nonane (209-210); or

6-(5-isopropyl-3-(4-(3-(methylsulfonyl) pyrrolidin-1-yl) cyclohexyl)-1H-indazol-6-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (211-212).

8. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically-acceptable salt thereof; and a pharmaceutically acceptable carrier.

9. A method of treating an autoimmune disease or a chronic inflammatory disease, comprising administering to a mammalian patent a compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein said autoimmune disease or chronic inflammatory disease is selected from systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis (MS), and Sjögren's syndrome.