IP Library › Granted Patent US 12,201,666
Granted Patent B2
US 12,201,666 · App. 17/132,467 · Granted Jan 21, 2025

Combination, composition, and method of administering the combination or composition to animals

Inventors: Kenneth W. Bafundo (Teaneck, NJ); A Bruce Johnson (Teaneck, NJ); David Calabotta (Quincy, IL); Wendell Knehans (Saint Louis, MO)
Assignees: Phibro Animal Health Corporation; Desert King International LLC
A61K36/88A23K20/10A23K50/00A23K50/70A23K50/75A61K31/35A61K36/185A61K36/73A61K36/896A61K38/05A61K38/15A61K39/012A61K2039/552
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Quick Facts
Patent No.
US 12,201,666
App. No.
17/132,467
Granted
Jan 21, 2025
Kind
B2
Abstract

Disclosed herein are embodiments of a combination and/or composition for administration to animals. In some embodiments, the combination and/or composition can be administered to treat and/or prevent a disease in animals. In some embodiments, the combination and/or composition can be administered to promote animal health. In some embodiments, the combination comprises a composition comprising Yucca schidigera, Quillaja saponaria , and combinations thereof and a composition comprising an antimicrobial, an antibiotic, an anticoccidial, a vaccine, or combinations thereof. The combinations or compositions disclosed herein can also improve feed conversion rates in animals.

Claims (32)

1. A composition consisting essentially of:

a mixture of Quillaja saponaria and Yucca schidigera in an amount ranging from 200 ppm to 5,000 ppm; and

an effective amount of an antibiotic, an anticoccidial agent, or a combination thereof.

2. The composition of claim 1 , further comprising a feedstuff.

3. The composition of claim 1 , further comprising an antimicrobial agent selected from penicillin, tetracycline, ceftiofur, florfenicol, tilmicosin, enrofloxacin, tulathromycin, procaine penicillin, benzathine penicillin, ampicillin, amoxicillin, spectinomycin, dihydrostreptomycin, chlortetracycline, gentamicin, sulphadimidine, trimethoprim, oxytetracycline, erythromycin, norfloxacin, virginiamycin, or combinations thereof.

4. The composition of claim 1 , wherein the anticoccidial agent is selected from salinomycin, monensin, lasalocid, narasin, maduramicin, semduramicin, laidlomycin, nicarbazin, or combinations thereof.

5. The composition of claim 1 , wherein the anticoccidial agent is salinomycin present at a concentration of 25 ppm to 90 ppm.

6. The composition of claim 3 , wherein the antimicrobial agent is virginiamycin present at a concentration of 10 ppm to 30 ppm.

7. The composition of claim 1 , wherein the Quillaja saponaria and the Yucca schidigera are present in a ratio ranging from 70:30 Quillaja saponaria:Yucca schidigera to 90:10 Quillaja saponaria:Yucca schidigera.

8. The composition of claim 1 , wherein the Quillaja saponaria is processed Quillaja saponaria plant material and the Yucca schidigera is processed Yucca schidigera plant material.

9. The composition of claim 8 , wherein the processed Quillaja saponaria plant material, the processed Yucca schidigera plant material, or both further comprises a Quillaja saponaria plant extract, a Yucca schidigera plant extract, or both.

10. The composition of claim 1 , wherein the amount of the mixture ranges from 200 ppm to 300 ppm, and the amount of the antibiotic, the anticoccidial agent, or the combination thereof ranges from 10 ppm to 70 ppm.

11. A combination composition consisting essentially of 200 ppm to 5,000 ppm of a mixture of Quillaja saponaria and Yucca schidigera , and an effective amount of an antibiotic, an anticoccidial agent, or a combination thereof, wherein the combination is formulated for administration to a chicken or turkey.

12. The combination of claim 11 , wherein the Quillaja saponaria and the Yucca schidigera are present in a ratio ranging from 70:30 Quillaja saponaria:Yucca schidigera to 90:10 Quillaja saponaria:Yucca schidigera.

13. The combination composition of claim 11 , further comprising a coccidiosis vaccine comprising oocysts obtained from Eimeria acervulina, Eimeria mivati, Eimeria maxima, Eimeria tenella, Eimeria necatrix, Eimeria mitis, Eimeria praecox, Eimeria brunetti, Eimeria hagani , or combinations thereof.

14. The combination composition of claim 11 , wherein the amount of the mixture ranges from 200 ppm to 300 ppm, and the amount of the antibiotic, the anticoccidial agent, or the combination thereof ranges from 10 ppm to 70 ppm.

15. A method comprising administering to an animal an effective amount of the composition of claim 1 .

16. The method of claim 15 , wherein the Quillaja saponaria and the Yucca schidigera are present in a ratio ranging from 70:30 Quillaja saponaria:Yucca schidigera to 90:10 Quillaja saponaria:Yucca schidigera.

17. The method of claim 15 , wherein the animal is a chicken or a turkey.

18. The method of claim 17 , wherein the chicken is a broiler meat-type chicken.

19. The method of claim 15 , wherein the animal has a lower feed conversion rate relative to an animal not administered the composition.

20. The method of claim 19 , wherein the feed conversion rate is improved by at least 0.5% to 5%.

21. The method of claim 15 , wherein the composition is administered at least once daily for a time period sufficient to promote a beneficial health effect on the digestive system of the animal relative to an animal not administered the composition.

22. The method of claim 21 , wherein the beneficial health effect on the animal comprises an earlier appearance of segmented filamentous bacteria, an increase in the abundance of segmented filamentous bacteria, an increase in the abundance of Lactobacillus , or a combination thereof.

23. A method comprising administering to a chicken or a turkey the combination composition of claim 11 at least once daily from day of age and for a time period sufficient to promote a beneficial health effect relative to a chicken or a turkey not administered the combination composition.

24. The method of claim 23 , further comprising administering a coccidiosis vaccine comprising oocysts obtained from Eimeria acervulina, Eimeria mivati, Eimeria maxima, Eimeria tenella, Eimeria necatrix, Eimeria mitis, Eimeria praecox, Eimeria brunetti, Eimeria hagani , or combinations thereof.

25. The method of claim 24 , wherein the combination composition and the coccidiosis vaccine are administered substantially simultaneously, or sequentially in any order.

26. The combination composition of claim 11 , further comprising an antimicrobial agent selected from penicillin, tetracycline, ceftiofur, florfenicol, tilmicosin, enrofloxacin, tulathromycin, procaine penicillin, benzathine penicillin, ampicillin, amoxicillin, spectinomycin, dihydrostreptomycin, chlortetracycline, gentamicin, sulphadimidine, trimethoprim, oxytetracycline, erythromycin, norfloxacin, virginiamycin, or combinations thereof.

27. The combination of claim 11 , wherein the anticoccidial agent is selected from salinomycin, monensin, lasalocid, narasin, maduramicin, semduramicin, laidlomycin, nicarbazin, or combinations thereof.

28. The combination composition of claim 11 , wherein the anticoccidial agent is salinomycin present at a concentration of 25 ppm to 90 ppm.

29. The combination composition of claim 26 , wherein the antimicrobial agent is virginiamycin present at a concentration of 10 ppm to 30 ppm.

30. The method of claim 23 , wherein the combination composition administered to the chicken or the turkey is admixed with a feedstuff.

Assignments (3)
SECURITY INTEREST Recorded Jul 15, 2024
From: PHIBRO ANIMAL HEALTH CORPORATION; PRINCE AGRI PRODUCTS, INC.; OMNIGEN RESEARCH, LLC
To: COÖPERATIEVE RABOBANK U.A., NEW YORK BRANCH, AS COLLATERAL AGENT
Reel/Frame 068370/0043 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2020
From: BAFUNDO, KENNETH W.; JOHNSON, A. BRUCE; KNEHANS, WENDELL; CALABOTTA, DAVID
To: PHIBRO ANIMAL HEALTH CORPORATION
Reel/Frame 054779/0359 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2020
From: PHIBRO ANIMAL HEALTH CORPORATION
To: PHIBRO ANIMAL HEALTH CORPORATION; DESERT KING INTERNATIONAL LLC
Reel/Frame 054779/0393 →
Continuity (5)
Continuation 16525383 · Jul 29, 2019
Continuation 15359342 · Nov 22, 2016
Continuation In Part PCTUS2015032301 · May 22, 2015
Provisional Application 62002527 · May 23, 2014
Related Publication 20210113647A1 · Apr 22, 2021
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