IP Library Granted Patent US 12,201,759
Granted Patent B2
US 12,201,759 · App. 17/625,124 · Granted Jan 21, 2025

Conductivity control systems

Inventors: Natalie Rebacz (Waltham, MA); Kerissa Adams (Norman, OK); Stephen A. Merchant (Waltham, MA); Mary Hoover (Waltham, MA)
Assignee: Fresenius Medical Care Holdings, Inc.
A61M1/1696A61M1/1524A61M1/154A61M1/155A61M1/1565A61M1/1605A61M1/1561A61M2205/3317
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,201,759
App. No.
17/625,124
Granted
Jan 21, 2025
Kind
B2
Abstract

A dialysis system has a module with a dialyzer configured to remove one or more substances from a dialysis solution as it passes through a dialyzer. The module has a fluid line, a sorbent cartridge, and a sodium control system adapted to actively alter a sodium concentration of dialysis solution passing through the fluid line as the dialysis solution exits the sorbent cartridge. The sodium control system has a conductivity sensor that sends a signal indicating the conductivity of the dialysis solution as the dialysis solution exits the sorbent cartridge, the conductivity meter being in communication with the sodium control system, a processor configured to receive the signal from the conductivity sensor, compare the conductivity signal to a threshold value lower than a prescription value, and cause the sodium control system to stop actively altering the sodium concentration if the signal is greater than the threshold value.

Claims (40)

1. A module configured to be connected to a dialysis machine having a dialyzer, the module being configured to remove one or more substances from a dialysis solution as the dialysis solution passes through the dialyzer, the module comprising:

a fluid line in fluid communication with the dialyzer;

a sorbent cartridge in fluid communication with the fluid line; and

a sodium control system in fluid communication with the fluid line, the sodium control system being adapted to actively alter a sodium concentration of the dialysis solution passing through the fluid line as the dialysis solution exits the sorbent cartridge; the sodium control system comprising:

a conductivity sensor that is adapted to send a conductivity signal indicating a conductivity of the dialysis solution as the dialysis solution exits the sorbent cartridge, the conductivity sensor being in communication with the sodium control system, and

a processor configured to receive the conductivity signal from the conductivity sensor, wherein the processor is configured to:

compare the conductivity signal to a threshold value lower than a prescription value, and cause the sodium control system to stop actively altering the sodium concentration of the dialysis solution if the conductivity signal is greater than the threshold value but below the prescription value, and

cause the sodium control system to add a diluent to the dialysis solution exiting the sorbent cartridge if the conductivity signal is greater than the prescription value.

2. The module according to claim 1 , comprising a first container that stores sodium bicarbonate in communication with the fluid line.

3. The module according to claim 2 , wherein the sodium control system is configured to introduce the sodium bicarbonate into the fluid line via a first pump.

4. The module according to claim 2 , wherein actively altering the sodium concentration of the dialysis solution comprises introducing the sodium bicarbonate into the fluid line.

5. The module according to claim 1 , comprising a second container that stores the diluent in communication with the fluid line.

6. The module according to claim 5 , wherein the sodium control system is configured to introduce the diluent from the second container to the fluid line.

7. The module according to claim 6 , wherein the sodium control system is configured to introduce the diluent to the fluid line when the processor indicates that the conductivity signal from the conductivity sensor is higher than the prescription value.

8. The module according to claim 1 , wherein the sorbent cartridge comprises at least one layer of material capable of regenerating spent dialysis solution.

9. A dialysis system, comprising:

a dialysis machine comprising a dialyzer; and

a module that is connected to the dialysis machine, the module being configured to remove one or more substances from a dialysis solution as the dialysis solution passes through the dialyzer, the module comprising:

a fluid line in fluid communication with the dialyzer;

a sorbent cartridge in fluid communication with the fluid line; and

a sodium control system in fluid communication with the fluid line, the sodium control system being adapted to actively alter a sodium concentration of the dialysis solution passing through the fluid line as the dialysis solution exits the sorbent cartridge; the sodium control system comprising:

a conductivity sensor that is adapted to send a conductivity signal indicating a conductivity of the dialysis solution as the dialysis solution exits the sorbent cartridge, the conductivity sensor being in communication with the sodium control system; and

a processor configured to receive the conductivity signal from the conductivity sensor, wherein the processor is configured to:

compare the conductivity signal to a threshold value lower than a prescription value, and cause the sodium control system to stop actively altering the sodium concentration of the dialysis solution if the conductivity signal is greater than the threshold value but below the prescription value, and

cause the sodium control system to add a diluent to the dialysis solution exiting the sorbent cartridge if the conductivity signal is greater than the prescription value.

10. The dialysis system according to claim 9 , wherein the dialysis machine is a hemodialysis machine.

11. The dialysis system according to claim 9 , wherein the module comprises a first container that stores sodium bicarbonate in communication with the fluid line.

12. The dialysis system according to claim 11 , wherein the sodium control system is configured to introduce the sodium bicarbonate into the fluid line via a first pump.

13. The dialysis system according to claim 11 , wherein actively altering the sodium concentration of the dialysis solution comprises introducing the sodium bicarbonate into the fluid line.

14. The dialysis system according to claim 13 , wherein the module comprises a second container that stores the diluent in fluid communication with the fluid line.

15. The dialysis system according to claim 14 , wherein the sodium control system is configured to introduce the diluent from the second container to the fluid line.

16. The dialysis system according to claim 15 , wherein the sodium control system is configured to introduce the diluent to the fluid line when the processor indicates that the conductivity signal from the conductivity sensor is higher than the prescription value.

17. The dialysis system according to claim 9 , wherein the sorbent cartridge comprises at least one layer of material capable of regenerating spent dialysis solution.

18. A method, comprising:

removing one or more substances from spent dialysis solution by passing the spent dialysis solution through a sorbent cartridge;

receiving a conductivity signal from a conductivity sensor;

comparing the conductivity signal to a threshold value that is lower than a prescription value;

stopping altering a sodium concentration of the spent dialysis solution exiting the sorbent cartridge when the conductivity signal is greater than the threshold value but below the prescription value; and

adding a diluent to the spent dialysis solution exiting the sorbent cartridge if the conductivity signal is greater than the prescription value.

19. The method according to claim 18 , further comprising passing the spent dialysis solution exiting the sorbent cartridge through a dialysis machine.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2022
From: REBACZ, NATALIE; ADAMS, KERISSA; MERCHANT, STEPHEN A.; HOOVER, MARY
To: FRESENIUS MEDICAL CARE HOLDINGS, INC.
Reel/Frame 059481/0750 →
Continuity (2)
Provisional Application 62882733 · Aug 5, 2019
Related Publication 20220265910A1 · Aug 25, 2022
References Cited (69)
US 2530581A · Markis et al. · 1950 [cited by applicant]
US 3973683A · Keller · 1976 [cited by applicant]
US 4001556A · Folchi et al. · 1977 [cited by applicant]
US 4229136A · Panissidi · 1980 [cited by applicant]
US 4274802A · Inaba et al. · 1981 [cited by applicant]
US 4363585A · Keller et al. · 1982 [cited by applicant]
US 4687941A · Laserberg et al. · 1987 [cited by applicant]
US 5111997A · Ikuta et al. · 1992 [cited by applicant]
US 5540668A · Wilson, Jr. et al. · 1996 [cited by applicant]
US 5622468A · Viollet · 1997 [cited by applicant]
US 6939111B2 · Huitt et al. · 2005 [cited by applicant]
US 7162884B2 · Alles · 2007 [cited by applicant]
US 7216672B1 · Chen · 2007 [cited by applicant]
US 8555926B2 · MacDuff et al. · 2013 [cited by applicant]
US 9827361B2 · Pudil et al. · 2017 [cited by applicant]
US 9931447B2 · Layser et al. · 2018 [cited by applicant]
US 10058694B2 · Norris et al. · 2018 [cited by applicant]
US 11000638B2 · Gagel · 2021 [cited by examiner]
US 11085552B2 · Moss et al. · 2021 [cited by applicant]
US 20030098270A1 · Thompson · 2003 [cited by applicant]
US 20040221904A1 · Usher et al. · 2004 [cited by applicant]
US 20050274658A1 · Rosenbaum et al. · 2005 [cited by applicant]
US 20070272311A1 · Trocki et al. · 2007 [cited by applicant]
US 20080172006A1 · Hicks · 2008 [cited by applicant]
US 20080214979A1 · Brugger et al. · 2008 [cited by applicant]
US 20090127193A1 · Updyke · 2009 [cited by examiner]
US 20100198129A1 · Sternby et al. · 2010 [cited by applicant]
US 20100312174A1 · Hoffman · 2010 [cited by applicant]
US 20110017665A1 · Updyke · 2011 [cited by examiner]
US 20120258545A1 · Ash · 2012 [cited by examiner]
US 20140088482A1 · Schlaeper et al. · 2014 [cited by applicant]
US 20140097371A1 · Huynh · 2014 [cited by applicant]
US 20150343127A1 · Childers et al. · 2015 [cited by applicant]
US 20160008529A1 · Hoffman · 2016 [cited by applicant]
US 20160239025A1 · van Dder Merwe et al. · 2016 [cited by applicant]
US 20170106131A1 · Hornig · 2017 [cited by applicant]
US 20170189598A1 · Slade · 2017 [cited by applicant]
US 20170304516A1 · Burnes · 2017 [cited by examiner]
US 20180021501A1 · Gerber · 2018 [cited by examiner]
US 20180229021A1 · Donlon et al. · 2018 [cited by applicant]
US 20190134289A1 · Pudil et al. · 2019 [cited by applicant]
US 20200030518A1 · Brugger et al. · 2020 [cited by applicant]
US 20200033897A1 · Jensen et al. · 2020 [cited by applicant]
US 20200041021A1 · Moss et al. · 2020 [cited by applicant]
US 20200179674A1 · Moss et al. · 2020 [cited by applicant]
US 20200271232A1 · Nakagami et al. · 2020 [cited by applicant]
US 20210299340A1 · Adams et al. · 2021 [cited by applicant]
US 20210341073A1 · Moss et al. · 2021 [cited by applicant]
CN 205368031U · 2016 [cited by examiner]
EP 1509261 · 2005 [cited by applicant]
EP 2694127 · 2014 [cited by applicant]
GB 2458572 · 2009 [cited by applicant]
WO WO2002043859 · 2002 [cited by applicant]
WO WO2002090671 · 2002 [cited by applicant]
WO WO2003099355 · 2003 [cited by applicant]
WO WO2009064984 · 2009 [cited by applicant]
WO WO2011017215 · 2011 [cited by applicant]
English translation of patent publication CN-205368031-U, published Jul. 6, 2016. (Year: 2016). [cited by examiner]
International Preliminary Report on Patentability in International Appln. No. PCT/US2019/042967, mailed Feb. 11, 2021, 7 pages. [cited by applicant]
International Preliminary Report on Patentability in International Appln. No. PCT/US2019/043023, mailed Feb. 11, 2021, 7 pages. [cited by applicant]
International Preliminary Report on Patentability in International Appln. No. PCT/US2019/044306, mailed Feb. 11, 2021, 8 pages. [cited by applicant]
International Preliminary Report on Patentability in International Appln. No. PCT/US2019/057775, mailed Jun. 17, 2021, 9 pages. [cited by applicant]
International Preliminary Report on Patentability in International Appln. No. PCT/US2020/044751, mailed Feb. 17, 2022, 11 pages. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2019/042967, dated Oct. 8, 2019, 11 pages. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2019/043023, dated Oct. 8, 2019, 9 pages. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2019/044306, mailed Oct. 24, 2019, 13 pages. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2019/057775, mailed Apr. 2, 2020, 17 pages. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2020/044751, mailed Nov. 4, 2020, 18 pages. [cited by applicant]
Invitation to Pay Additional Fees in International Application No. PCT/US2019/057775, dated Feb. 11, 2020, 11 pages. [cited by applicant]