IP Library › Granted Patent US 12,208,239
Granted Patent B2
US 12,208,239 · App. 17/270,531 · Granted Jan 28, 2025

Fluid injector system, method of preventing fluid backflow, and computer program product

Inventors: Michael McDermott (Pittsburgh, PA); William Barone (Pittsburgh, PA); John Volkar (Valencia, PA)
Assignee: BAYER HEALTHCARE LLC
A61M5/16827A61M5/1422A61M5/16854A61M5/007A61M2005/1406A61M2005/14208
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Quick Facts
Patent No.
US 12,208,239
App. No.
17/270,531
Granted
Jan 28, 2025
Kind
B2
Abstract

A fluid injector system and method for preventing pressurized backflow of a second fluid into a first reservoir containing a fluid is described. The fluid injector system includes a control device programmed or configured to actuate a second drive component to pressurize and inject the second fluid through the fluid conduit, and while the second drive component is actuated, actuate a first drive component to introduce intermittent pulses of the first fluid to create a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir.

Claims (38)

1. A fluid injector system configured to perform an injection protocol, the fluid injector system comprising:

a control device operatively associated with each of two or more drive components configured to pressurize and inject a first fluid from a first fluid reservoir through a fluid conduit, and at least a second fluid from a second fluid reservoir through the fluid conduit, the fluid conduit being in selective fluid communication with the first fluid reservoir and at least the second fluid reservoir, the control device comprising at least one processor programmed or configured to:

actuate a second drive component of the two or more drive components to pressurize and inject the second fluid through the fluid conduit;

while the second drive component of the two or more drive components is actuated, actuate a first drive component of the two or more drive components to introduce a first set of intermittent pulses of the first fluid to create a turbulent flow in the fluid path at a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir,

monitor a pressure in the first fluid reservoir and a pressure in the second fluid reservoir during injection of the first fluid and the second fluid to determine if a difference between the pressure in the first fluid reservoir and the pressure in the second fluid reservoir reaches a first predetermined value, and

once the first predetermined value is reached, start a second set of intermittent pulses of the first fluid through the fluid conduit in order to prevent the second fluid from entering the first fluid reservoir.

2. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to actuate the first drive component of the two or more drive components to continue to introduce the first set of intermittent pulses of the first fluid until a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid.

3. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to further actuate the first drive component of the two or more drive components to introduce the first set of intermittent pulses of the first fluid at a frequency or amplitude selected from the group consisting of an increasing frequency, a decreasing frequency, an increasing amplitude, a decreasing amplitude, and any combination thereof, based on at least one of a difference in pressure in the first fluid reservoir compared to the second fluid reservoir, a difference in an observed ratio of the first fluid and the second fluid compared to a desired ratio of the first fluid and the second fluid, a change in a fluid flow rate or pressure in the fluid conduit, a detection of backflow of the second fluid, a difference in fluid properties of the first fluid and the second fluid, and combinations of any thereof.

4. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to decrease at least one of a frequency and an amplitude of or alter a wave form of the first set of intermittent pulses of the first fluid and deliver the first fluid at a first fluid flow rate and the second fluid at a second fluid flow rate at a desired ratio of the first fluid and the second fluid through the fluid conduit.

5. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to monitor an injection pressure in the fluid conduit and determine whether the injection pressure changes by a second predetermined value.

6. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to calculate a predetermined injection pressure based on at least one of a programmed injection protocol and user input information, and in response, adjust a pre-set waveform of the first set of intermittent pulses of the first fluid.

7. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to continuously monitor a rate of change of an injection pressure in the fluid conduit, and in response, adjust at least one of a pulse interval, a pulse flow rate, and a pulse volume of the first set of intermittent pulses of the first fluid based on a lookup table or a predetermined algorithm.

8. The fluid injector system of claim 1 , wherein, when the first set of intermittent pulses of the first fluid are introduced, the at least one processor is further programmed or configured to select at least one of a pulse interval, a pulse flow rate, and a pulse volume from a lookup table or a predetermined algorithm.

9. The fluid injector system of claim 1 , wherein less than 40 milliliters of the first fluid is introduced into the fluid conduit by actuation of the first drive component of the two or more drive components before a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid.

10. The fluid injector system of claim 1 , wherein, while the first drive component of the two or more drive components introduces the first set of intermittent pulses of the first fluid to create the flow front interface between the first fluid and the second fluid in the fluid conduit, a total volume of the first fluid introduced into the fluid conduit is less than the sum of a user programmed volume and 15 milliliters.

11. The fluid injector system of claim 1 , wherein, when the first drive component of the two or more drive components is actuated, a capacitance volume of the first fluid reservoir increases and none of the second fluid enters the first fluid reservoir.

12. A fluid injector system configured to perform an injection protocol, the fluid injector system comprising:

a control device operatively associated with each of two or more drive components configured to pressurize and inject a first fluid from a first fluid reservoir through a fluid conduit, and at least a second fluid from a second fluid reservoir through the fluid conduit, the fluid conduit being in selective fluid communication with the first fluid reservoir and at least the second fluid reservoir, the control device comprising at least one processor programmed or configured to:

actuate a second drive component of the two or more drive components to pressurize and inject the second fluid through the fluid conduit;

while the second drive component is actuated, actuate a first drive component of the two or more drive components to introduce a first set of intermittent pulses of the first fluid to create a turbulent flow in the fluid path at a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit in to the first fluid reservoir;

continue to introduce the first set of intermittent pulses of the first fluid until a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid;

decrease at least one of a frequency and an amplitude of or alter a wave form of the first set of intermittent pulses of the first fluid and deliver the first fluid at a first fluid flow rate and the second fluid at a second fluid flow rate at a desired ratio of the first fluid and the second fluid through the fluid conduit;

either monitor a pressure in the first fluid reservoir and a pressure in the second fluid reservoir during injection of the first fluid and the second fluid to determine if a difference between the pressure in the first fluid reservoir and the pressure in the second fluid reservoir reaches a first predetermined value, or monitor an injection pressure in the fluid conduit and determine whether the injection pressure changes by a second predetermined value; and

once a corresponding one of the first predetermined value and the second predetermined value is reached, start a second set of intermittent pulses of the first fluid through the fluid conduit in order to prevent the second fluid from entering the first fluid reservoir.

13. A method of preventing a second fluid from a second fluid reservoir from flowing back into a first fluid reservoir in a fluid injector system configured to perform an injection protocol, the method comprising:

providing a control device operatively associated with a first drive component and a second drive component, the first drive component configured to pressurize and inject a first fluid through a fluid conduit, the second drive component configured to pressurize and inject at least the second fluid from the second fluid reservoir through the fluid conduit;

actuating the second drive component to pressurize and inject the second fluid through the fluid conduit;

while the second drive component is actuated, actuating the first drive component to introduce a first set of intermittent pulses of the first fluid to create a turbulent flow in the fluid path at a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir

monitoring a pressure in the first fluid reservoir and a pressure in the second fluid reservoir during injection of the first fluid and the second fluid to determine if a difference between the pressure in the first fluid reservoir and the pressure in the second fluid reservoir reaches a first predetermined value; and

once the first predetermined value is reached, starting a second set of intermittent pulses of the first fluid through the fluid conduit with the at least one processor in order to prevent the second fluid from entering the first fluid reservoir.

14. The method of claim 13 , further comprising actuating the first drive component to continue to introduce the first set of intermittent pulses of the first fluid until a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid.

15. The method of claim 13 , further comprising actuating the first drive component to introduce the first set of intermittent pulses of the first fluid at a frequency or amplitude selected from the group consisting of an increasing frequency, a decreasing frequency, an increasing amplitude, a decreasing amplitude, and any combination thereof, based on at least one of a difference in pressure in the first fluid reservoir compared to the second fluid reservoir, a difference in an observed ratio of the first fluid and the second fluid compared to a desired ratio of the first fluid and the second fluid, a change in a fluid flow rate or pressure in the fluid conduit, a detection of backflow of the second fluid, a difference in fluid properties of the first fluid and the second fluid, and combinations of any thereof.

16. The method of claim 13 , further comprising decreasing at least one of a frequency and an amplitude of or alter a wave form of the first set of intermittent pulses of the first fluid and deliver the first fluid at a first fluid flow rate and the second fluid at a second fluid flow rate at a desired ratio of the first fluid and the second fluid through the fluid conduit.

17. The method of claim 13 , further comprising monitoring an injection pressure in the fluid conduit and determine whether the injection pressure changes by a second predetermined value.

18. The method of claim 13 , further comprising calculating a predetermined injection pressure based on at least one of a programmed injection protocol and user input information, and in response, adjusting a pre-set waveform of the first set of intermittent pulses of the first fluid.

19. The method of claim 13 , further comprising monitoring a rate of change of an injection pressure in the fluid conduit, and in response, adjusting at least one of a pulse interval, a pulse flow rate, and a pulse volume of the first set of intermittent pulses of the first fluid based on a lookup table or a predetermined algorithm.

20. The method of claim 13 , further comprising, when the first set of intermittent pulses of the first fluid are introduced, selecting at least one of a pulse interval, a pulse flow rate, and a pulse volume from a lookup table or a predetermined algorithm with the at least one processor.

21. The method of claim 13 , wherein less than 40 milliliters of the first fluid is introduced into the fluid conduit by actuating the first drive component before a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2021
From: MCDERMOTT, MICHAEL; BARONE, WILLIAM; VOLKAR, JOHN
To: BAYER HEALTHCARE LLC
Reel/Frame 055364/0759 →
Continuity (2)
Provisional Application 62723739 · Aug 28, 2018
Related Publication 20210220556A1 · Jul 22, 2021
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