Granted Patent B2

US 12,226,613 · App. 18/063,212 · Granted Feb 18, 2025

Inventors: Bryan C. Grygus (Clifton Park, NY); Alfred Marino (Housatonic, MA); Rachel P. Arnott (San Francisco, CA); Scott Barton (Clifton Park, NY); Bart E. Burgess (Bernville, PA); Richard Gildersleeve (Rensselaer, NY); Alexei Goraltchouk (Cambridge, MA); Daniel Halbig (Ballston Lake, NY); Christopher Kanel (Hudson, NY); Trevor Langley (Rensselaer, NY)

Assignee: Regeneron Pharmaceuticals, Inc.

A61M5/2033A61M5/3202A61M2005/2013A61M2205/103A61M2209/088

Abstract

Claims (40)

1. An injection device, comprising:

a needle movable from a retracted configuration to a deployed configuration;

a piston configured to move within a vial;

a motor configured to apply force against the piston; and

a controller coupled to the motor, wherein the controller is configured to:

receive an indication that the injection device is positioned in contact with a user;

after receiving the indication, sending a signal to the motor to apply force against the piston in a first direction, wherein applying force in the first direction causes the needle to move from the retracted configuration to the deployed configuration; and

without requiring any intervention by a user after receiving the indication, and after sending the signal to the motor to apply force against the piston in the first direction, automatically sending a signal to the motor to apply force against the piston in a second direction, wherein applying force in the second direction causes the needle to retract.

2. The injection device of claim 1 , further including a housing enclosing the vial, the piston, the motor, the controller, and the needle when the needle is in the retracted configuration, wherein the needle extends out of the housing in the deployed configuration.

3. The injection device of claim 1 , further including a cover or a shield that contains a distalmost portion of the needle in the retracted configuration.

4. The injection device of claim 1 , further including an audio module, a visual module, and a haptic module, each of the modules being coupled to the controller and configured to provide feedback to a user of the injection device.

5. The injection device of claim 1 , wherein the vial is configured to be in fluid communication with the needle, further including a top that seals an opening of the vial, the top including a portion including a rubber material that is permeable to a sterilant, wherein the needle includes a proximalmost portion configured to be coupled with the vial, and, before the needle and vial are in fluid communication with one another, the proximalmost portion of the needle is disposed within the portion formed of the rubber material.

6. The injection device of claim 1 , further including a cantilever coupled to the controller, and movable by the needle, wherein, when the needle is in the retracted configuration, the cantilever forms part of an open circuit that signals to the controller that the needle is in the retracted configuration, and when the needle is in the deployed configuration, the cantilever forms part of a closed circuit that signals to the controller that the needle is in the deployed configuration.

7. The injection device of claim 1 , further including one or more spring contacts configured to form an electrical connection between the motor to the controller.

8. The injection device of claim 1 , further including an activating switch movable between an extended position and a depressed position;

wherein the indication is based at least in part on the activating switch being in the depressed position.

9. The injection device of claim 1 , further including a touch sensor configured to detect contact with skin,

wherein the indication is based at least in part on the touch sensor detecting contact with skin.

10. The injection device of claim 9 , wherein the touch sensor includes a capacitive sensing electrode and is configured to detect contact with skin based on a change in a capacitance of the capacitive sensing electrode.

11. The injection device of claim 1 , further including:

an emitter configured to transmit light through the vial; and

a detector configured to receive the light and to detect interruption of the light by the piston.

12. The injection device of claim 11 , wherein the controller is further configured to send the signal to the motor to apply force against the piston in the second direction in response to interruption of the light by the piston.

13. The injection device of claim 11 , wherein the controller is further configured, after a predetermined delay, to send the signal to the motor to apply force against the piston in the second direction in response to interruption of the light by the piston.

14. The injection device of claim 1 , further including a wireless communication module configured to transmit to a remote device one or more of: diagnostic information of the injection device, information indicative of an error state of the injection device, and information indicative of completion of an injection.

15. The injection device of claim 1 , further including a wireless communication module configured to receive an activation command from a remote device, wherein the indication is based at least in part on the activation command.

16. The injection device of claim 1 , wherein the vial is configured to be in fluid communication with the needle.

17. The injection device of claim 1 , wherein in response to the motor applying force against the piston in the first direction, the needle is put in fluid communication with the vial.

18. A controller for an injection device comprising:

one or more memories storing instructions; and

one or more processors operatively connected to the one or more memories, the one or more processors configured to execute the instructions to:

receive an indication that the injection device is positioned in contact with a user;

after receiving the indication, send a signal to a motor to apply force against a piston in a first direction within a vial, wherein applying force in the first direction causes a needle to move from a retracted configuration to a deployed configuration; and

without requiring any intervention by a user after receiving the indication, and after sending the signal to the motor to apply force against the piston in the first direction, automatically sending a signal to the motor to apply force against the piston in a second direction, wherein applying force in the second direction causes the needle to retract.

19. The controller of claim 18 , wherein the controller is further configured to:

receive, from a detector, a light interruption signal indicative of an interruption of a light transmitted through the vial by an emitter; and

send the signal to the motor to apply force against the piston in the second direction in response to the light interruption signal.

20. The controller of claim 18 , wherein the controller is further configured to:

receive, from a detector, a light interruption signal indicative of an interruption of a light transmitted through the vial by an emitter; and

send, after a predetermined delay, the signal to the motor to apply force against the piston in the second direction in response to the light interruption signal.

Assignments (1)

Continuity (3)

References Cited (400)