IP Library › Granted Patent US 12,234,236
Granted Patent B1
US 12,234,236 · App. 18/884,965 · Granted Feb 25, 2025

GLP-1R agonist and therapeutic method thereof

Inventors: Bin Liang (Hong Kong, CN); Jinzi Jason Wu (Hong Kong, CN); Bailing Yang (Hong Kong, CN)
Assignee: Ascletis Pharma (China) Co., Limited
C07D471/04A61K31/437C07D519/00
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Quick Facts
Patent No.
US 12,234,236
App. No.
18/884,965
Granted
Feb 25, 2025
Kind
B1
Abstract

The present disclosure describes GLP-1R modulating compounds that are useful for treating GLP-1R-mediated diseases or conditions,

Claims (25)

1. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

2. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is selected from the group consisting of a sodium salt, a calcium salt, a potassium salt, a magnesium salt and a lithium salt.

3. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is selected from the group consisting of:

4. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is selected from the group consisting of:

5. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is selected from the group consisting of:

6. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is selected from the group consisting of:

7. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

8. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

9. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

10. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

11. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

12. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

13. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

14. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

15. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

16. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

17. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

18. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

19. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

20. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

21. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

22. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

23. The compound or the pharmaceutically acceptable salt thereof of claim 1 , wherein the pharmaceutically acceptable salt is

24. A compound, selected from the group consisting of:

25. A pharmaceutical composition, comprising the compound or the pharmaceutically acceptable salt thereof of claim 1 , and a pharmaceutically acceptable excipient.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 24, 2025
From: LIANG, BIN; WU, JINZI JASON; YANG, BAILING
To: ASCLETIS PHARMA (CHINA) CO., LIMITED
Reel/Frame 069998/0436 →
Priority Claims (10)
CN 202311189557.X · Sep 14, 2023 · national
CN 202311371725.7 · Oct 23, 2023 · national
CN 202311582240.2 · Nov 24, 2023 · national
CN 202311686034.6 · Dec 8, 2023 · national
CN 202410142451.2 · Jan 31, 2024 · national
CN 202410202078.5 · Feb 22, 2024 · national
CN 202410398964.X · Apr 2, 2024 · national
CN 202410584679.7 · May 11, 2024 · national
CN 202410963587.X · Jul 17, 2024 · national
CN 202411237048.4 · Sep 4, 2024 · national
Continuity (4)
Provisional Application 63673453 · Jul 19, 2024
Provisional Application 63603854 · Nov 29, 2023
Provisional Application 63545615 · Oct 25, 2023
Provisional Application 63538892 · Sep 18, 2023
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