Bone graft composition and manufacturing method thereof
The present disclosure relates to a bone graft composition, and more particularly, to a bone graft composition containing hydroxypropyl methylcellulose and a preparation method therefor. In addition, the present disclosure relates to a bone graft composition containing hydroxypropyl methylcellulose in an amount that provides shape retainability, and a preparation method therefor.
1. A bone graft composition consisting of a bone graft material and hydroxypropyl methylcellulose (HPMC),
wherein the HPMC maintains the shape of the bone graft composition after implantation in a bone defect portion so as to have a shape retainability of 50 or more,
wherein the shape retainability is defined as a value obtained by dividing a maximum breaking force (Nmax) by a short-axis change rate, in which the maximum breaking force (Nmax) is a force at which a change in shape of a sphere-shaped material is initiated by applying a force (N) to one side of the sphere-shaped material, and the short-axis change rate is a ratio (D-S)/(D) of a reduction in short-axis length (S) of the sphere-shaped material, measured after the change in the shape occurred, to a diameter (D) of the sphere-shaped material,
wherein the bone graft composition consists of 1 to 3 parts by weight of the HPMC with respect to 1 part by weight of the bone graft material for enhancing the shape retention ability, and
wherein the bone graft material consists of an autogenous bone graft material, an allogeneic bone graft material, or a xenogenic bone graft material.
2. The bone graft composition of claim 1 , wherein the bone graft material is a porous structure.
3. The bone graft composition of claim 1 , wherein the autogenous bone graft material is an autogenous bone graft powder, the allogeneic bone graft material is a allogeneic bone graft powder, and the xenogenic bone graft material is an xenogenic bone graft powder.
4. The bone graft composition of claim 3 , wherein the average particle diameter (D50) of the autogenous bone graft powder, the allogeneic bone graft powder, and the xenogenic bone graft powder is between 200 μm and 5,000 μm.
5. The bone graft composition of claim 4 , wherein the average particle diameter (D50) of the autogenous bone graft powder, the allogeneic bone graft powder, and the xenogenic bone graft powder is between 250 μm and 1,000 μm.
6. A bone graft composition comprising a bone graft material and hydroxypropyl methylcellulose (HPMC),
wherein the HPMC maintains the shape of the bone graft composition after implantation in a bone defect portion so as to have a shape retainability of 50 or more,
wherein the shape retainability is defined as a value obtained by dividing a maximum breaking force (Nmax) by a short-axis change rate, in which the maximum breaking force (Nmax) is a force at which a change in shape of a sphere-shaped material is initiated by applying a force (N) to one side of the sphere-shaped material, and the short-axis change rate is a ratio (D-S)/(D) of a reduction in short-axis length(S) of the sphere-shaped material, measured after the change in the shape occurred, to a diameter (D) of the sphere-shaped material,
wherein the bone graft composition comprises of 0.3 to 3 parts by weight of the HPMC with respect to 1 part by weight of the bone graft material for enhancing the shape retention ability,
wherein the bone graft material consists of an autogenous bone graft powder, an allogeneic bone graft powder, or a xenogenic bone graft powder and a bone morphogenetic protein adsorbed thereon, and
wherein the HPMC is a HPMC powder.
7. The bone graft composition of claim 6 , wherein the bone graft composition comprises 0.4 to 2 parts by weight of the HPMC with respect to 1 part by weight of the bone graft material.
8. The bone graft composition of claim 7 , wherein the bone graft material comprises a porous structure.
9. The bone graft composition of claim 6 , wherein the bone graft composition has a maximum breaking force in the range of 10 N to 35 N.
10. The bone graft composition of claim 6 , wherein the bone graft composition consists of 0.3 to 3 parts by weight of the HPMC powder with respect to 1 part by weight of the bone graft material.
11. The bone graft composition of claim 6 , wherein the volume ratio of the bone graft material and the HPMC powder is 1:0.2 to 1:0.6.
12. The bone graft composition of claim 10 , wherein the bone graft composition consists of 0.4 to 2 parts by weight of the HPMC powder with respect to 1 part by weight of the bone graft material.
13. The bone graft composition of claim 10 , wherein the bone graft composition consists of 0.6 to 1.5 parts by weight of the HPMC powder with respect to 1 part by weight of the bone graft material.
14. The bone graft composition of claim 10 , wherein the bone graft composition consists of 1 to 3 parts by weight of the HPMC powder with respect to 1 part by weight of the bone graft material.
15. The bone graft composition of claim 6 , wherein the average particle diameter (D50) of the autogenous bone graft powder, the allogeneic bone graft powder, and the xenogenic bone graft powder is between 200 μm and 5,000 μm.
16. The bone graft composition of claim 15 , wherein the average particle diameter (D50) of the autogenous bone graft powder, the allogeneic bone graft powder, and the xenogenic bone graft powder is between 250 μm and 1,000 μm.
17. The bone graft composition of claim 6 , wherein bone morphogenetic protein is rhBMP-2.
18. The bone graft composition of claim 6 , wherein the bone graft composition consists of the bone graft material and the HPMC.
19. A bone graft composition comprising a bone graft material and hydroxypropyl methylcellulose (HPMC),
wherein the HPMC maintains the shape of the bone graft composition after implantation in a bone defect portion so as to have a shape retainability of 50 or more,
wherein the shape retainability is defined as a value obtained by dividing a maximum breaking force (Nmax) by a short-axis change rate, in which the maximum breaking force (Nmax) is a force at which a change in shape of a sphere-shaped material is initiated by applying a force (N) to one side of the sphere-shaped material, and the short-axis change rate is a ratio (D-S)/(D) of a reduction in short-axis length(S) of the sphere-shaped material, measured after the change in the shape occurred, to a diameter (D) of the sphere-shaped material,
wherein the bone graft composition comprises 0.6 to 1.5 parts by weight of the HPMC with respect to 1 part by weight of the bone graft material for enhancing the shape retention ability,
wherein the bone graft material consists of an autogenous bone graft powder, an allogeneic bone graft powder, or a xenogenic bone graft powder and a bone morphogenetic protein adsorbed thereon, and
wherein the HPMC is a HPMC powder.
20. The bone graft composition of claim 19 , wherein the bone graft material comprises a porous structure.