Apparatus for treating excess intraocular fluid having an elastic membrane
View Patent ↗Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.
1. A method for treating excess fluid pressure within an eye, the method comprising:
implanting an implantable device under a conjunctiva of the eye, such that a first end of the implantable device is in fluid communication with an anterior chamber of the eye and a second end of the implantable device is in fluid communication with a space beneath tissue of the eye, the implantable device comprising a cavity having a circular-shaped cross-section, an elastic membrane disposed within the cavity to define a fluidic channel between the first and second ends, and a local constriction disposed within the fluidic channel, coaxial with the cavity to reduce an area of the fluidic channel,
wherein the elastic membrane is configured to deform, responsive to pressure fluctuations between the first and second ends, to change a volume of the fluidic channel to vary fluidic resistance of fluid flowing from the first end, across one or more grooves disposed on an outer surface of the local constriction, to the second end to thereby maintain pressure at the first end relatively constant.
2. The method of claim 1 , wherein implanting the implantable device comprises implanting a nozzle having an outlet end fluidically coupled to the first end, such that an inlet end of the nozzle passes through a wall of the eye to communicate with the anterior chamber of the eye.
3. The method of claim 1 , wherein implanting the implantable device comprises implanting a drainage tube having a proximal end fluidically coupled to the second end, such that a distal region of the drainage tube is disposed within the space between the tissue of the eye.
4. The method of claim 3 , wherein the distal region of the drainage tube comprises one or more drainage holes.
5. The method of claim 3 , wherein the distal region of the drainage tube is disposed within a groove of a diffuser plate, and wherein implanting the drainage tube comprises disposing the diffuser plate on a scleral surface of the eye.
6. The method of claim 5 , wherein the diffuser plate is a Seton tube.
7. The method of claim 1 , wherein the first end is fluidically coupled to a diffuser plate, and wherein implanting the implantable device under the conjunctiva of the eye comprises disposing the diffuser plate on a scleral surface of the eye.
8. The method of claim 1 , wherein implanting the implantable device under the conjunctiva of the eye comprises implanting the implantable device above a sclera.
9. The method of claim 8 , further comprising positioning a protective patch above the implantable device to protect a conjunctival layer from device-induced erosion.
10. The method of claim 1 , wherein implanting the implantable device under the conjunctiva of the eye comprises implanting the implantable device under the conjunctiva of the eye, such that the second end of the implantable device is in fluid communication with the space beneath the conjunctiva or a rear space of the eye.
11. The method of claim 10 , wherein the rear space of the eye comprises an orbital fat space of the eye.
12. The method of claim 1 , wherein the implantable device comprises a housing shell configured to be implanted beneath the conjunctiva, the housing shell comprising the first and second ends and the cavity.
13. The method of claim 12 , wherein the local constriction is disposed within a center of the housing shell.
14. The method of claim 12 , wherein the housing shell has a radius of curvature selected to accommodate a radius of curvature of the eye.
15. The method of claim 12 , wherein an outer surface of the housing shell comprises a cylindrical shape.
16. The method of claim 1 , wherein the elastic membrane is configured to deform when forces applied to the elastic membrane exceed a predetermined level of force.
17. The method of claim 1 , wherein the elastic membrane is configured to seal off the fluidic channel.
18. The method of claim 1 , wherein, when the elastic membrane is in a deformed state, the elastic membrane comprises a parabolic shape such that the fluidic channel has a largest cross-sectional area adjacent a center of the elastic membrane, and reduces in size towards the first and second ends.
19. The method of claim 1 , wherein an elasticity of the elastic membrane is selected to establish a balance between an external pressure at the second end and an internal pressure of the eye at the first end.
20. The method of claim 1 , wherein the local constriction extends along an entire length of the fluidic channel.
21. The method of claim 1 , wherein the outer surface of the local constriction forms a lower surface of the fluidic channel, and wherein the elastic membrane forms an upper surface of the fluidic channel.
22. The method of claim 1 , wherein the local constriction has a circular cross-section.