IP Library Granted Patent US 12,274,873
Granted Patent B1
US 12,274,873 · App. 18/594,556 · Granted Apr 15, 2025

Medicament delivery device

Inventors: Alexander Hee-Hanson (Melbourn, GB); Thomas Lever (Melbourn, GB); Michael Parrott (Melbourn, GB); Robert Wilson (Melbourn, GB)
Assignee: Genzyme Corporation
A61M5/3234A61M5/3245A61M5/2033A61M2005/208
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Quick Facts
Patent No.
US 12,274,873
App. No.
18/594,556
Granted
Apr 15, 2025
Kind
B1
Abstract

A medicament delivery device includes a needle disposed at a distal end of the medicament delivery device. The medicament delivery device includes a body for a syringe and a needle cover axially movable relative to the body between an extended position in which the needle cover covers the needle and a retracted position in which the needle protrudes from the distal end of the needle cover. The medicament delivery device includes a plunger axially movable relative to the body to dispense medicament from the medicament delivery device. The medicament delivery device includes a needle cover biasing mechanism configured to bias the needle cover distally from the retracted position to the extended position. The medicament delivery device includes a locking mechanism configured to be moved by the plunger from an initial configuration to an engaged configuration to prevent a distal movement of the needle cover biasing mechanism.

Claims (48)

1. A medicament delivery device comprising:

a needle for injecting medicament, the needle disposed at a distal end of the medicament delivery device;

a body configured to receive a syringe;

a needle cover axially movable relative to the body between an extended position, in which a distal end of the needle cover is distal to a distal end of the needle, and a retracted position, in which the distal end of the needle is distal to the distal end of the needle cover;

a plunger axially movable relative to the body from a proximal position to a distal position to dispense a medicament from the medicament delivery device;

a needle cover biasing mechanism configured to bias the needle cover distally from the retracted position to the extended position; and

a locking mechanism configured to be moved by the plunger from an initial configuration to an engaged configuration to limit a distal movement of the needle cover biasing mechanism relative to the body.

2. The medicament delivery device of claim 1 , wherein distal movement of the plunger from the proximal position causes the locking mechanism to be moved from the initial configuration to the engaged configuration.

3. The medicament delivery device of claim 1 , wherein the needle cover biasing mechanism is configured to limit movement of the locking mechanism from the initial configuration until the needle cover has moved to the retracted position.

4. The medicament delivery device of claim 1 , wherein the needle cover biasing mechanism comprises a shuttle member and a spring, wherein the spring is configured to exert a biasing force on the shuttle member which biases the shuttle member axially towards the distal end of the medicament delivery device, and the shuttle member is configured to transfer the biasing force to the needle cover to bias the needle cover distally from the retracted position to the extended position.

5. The medicament delivery device of claim 1 , wherein the needle cover biasing mechanism comprises one or more first slots and wherein the locking mechanism comprises one or more resilient members, wherein the one or more resilient members are each configured to be received by a respective one of the one or more first slots after movement of the locking mechanism from the initial configuration to the engaged configuration by the plunger such that when the one or more resilient members are in the one or more first slots, distal movement of the needle cover biasing mechanism relative to the body is limited.

6. The medicament delivery device of claim 5 , wherein the one or more resilient members each comprise a flexible arm and a first protrusion disposed on an end of the flexible arm, wherein each first protrusion of the one or more resilient members is configured to be received by a respective one of the one or more first slots after movement of the locking mechanism from the initial configuration to the engaged configuration by the plunger such that when each first protrusion is in the respective one or more first slots, distal movement of the needle cover biasing mechanism is limited.

7. The medicament delivery device of claim 5 , wherein the one or more resilient members are each held in a respective one of the one or more first slots by an outer surface of the plunger while the plunger moves between the proximal position and the distal position.

8. The medicament delivery device of claim 5 , wherein the one or more resilient members are configured to disengage from the respective one of the one or more first slots when the plunger is in the distal position.

9. The medicament delivery device of claim 5 , wherein the one or more first slots are recesses or apertures.

10. The medicament delivery device of claim 5 , wherein the plunger comprises one or more second slots, and wherein the one or more resilient members are each configured to engage a respective one of the one or more second slots when the locking mechanism is in the initial configuration such that when the one or more resilient members are engaged to the one or more second slots, distal movement of the plunger from the proximal position relative to the body is limited.

11. The medicament delivery device of claim 10 , wherein the one or more second slots comprise recesses or apertures.

12. The medicament delivery device of claim 10 , wherein at least one of a distal-facing edge of each of the one or more second slots or a proximal-facing edge of each of one or more second protrusions is beveled.

13. The medicament delivery device of claim 10 , wherein the one or more resilient members are each configured to disengage the respective one of the one or more second slots responsive to the needle cover being moved to the retracted position.

14. The medicament delivery device of claim 1 , further comprising a drive spring configured to exert a force on the plunger which biases the plunger axially towards the distal end of the medicament delivery device.

15. The medicament delivery device of claim 1 , further comprising the syringe containing the medicament.

16. A medicament delivery device comprising:

a body configured to contain a syringe;

a needle cover axially movable relative to the body between an extended position, in which the needle cover covers a needle coupled to the syringe, and a retracted position, in which the needle protrudes from a distal end of the needle cover;

a plunger configured to dispense a medicament from the medicament delivery device;

a needle cover biasing mechanism configured to bias the needle cover from the retracted position to the extended position; and

a locking mechanism configured to be actuated by a first movement of the plunger relative to the body such that when the locking mechanism is actuated, the locking mechanism limits the needle cover biasing mechanism from biasing the needle cover to the extended position.

17. The medicament delivery device of claim 16 , wherein the needle cover biasing mechanism comprises a shuttle member and a biasing member, the biasing member being configured to exert a force on the shuttle member to bias the needle cover from the retracted position to the extended position.

18. The medicament delivery device of claim 17 , wherein the shuttle member and the needle cover define a monolithic structure.

19. The medicament delivery device of claim 17 , wherein the biasing member comprises a spring.

20. The medicament delivery device of claim 16 , wherein the locking mechanism comprises a resilient member configured to be deflected by the first movement of the plunger.

21. The medicament delivery device of claim 20 , wherein the resilient member is configured to be deflected by the first movement of the plunger to engage a first slot of the needle cover biasing mechanism to limit the needle cover biasing mechanism from biasing the needle cover to the extended position.

22. The medicament delivery device of claim 21 , wherein the resilient member comprises a flexible arm and a first protrusion disposed on an end of the flexible arm, wherein the first protrusion is configured to enter the first slot to limit the needle cover biasing mechanism from biasing the needle cover to the extended position.

23. The medicament delivery device of claim 21 , wherein the resilient member is configured to be held in engagement with the first slot by an outer surface of the plunger during a second movement of the plunger, the second movement subsequent to the first movement.

24. The medicament delivery device of claim 23 , wherein the second movement occurs during medicament delivery.

25. The medicament delivery device of claim 23 , wherein the resilient member is configured to disengage from the first slot during a third movement of the plunger to cause the needle cover biasing mechanism to bias the needle cover to the extended position, the third movement subsequent to the second movement.

26. The medicament delivery device of claim 25 , wherein the third movement corresponds to a completion of medicament delivery.

27. The medicament delivery device of claim 21 , wherein the plunger comprises a second slot, and wherein the resilient member is configured to engage the second slot while the needle cover is in the extended position to limit the first movement of the plunger.

28. The medicament delivery device of claim 27 , wherein the resilient member is configured to disengage the second slot responsive to the needle cover being moved to the retracted position such that when the resilient member is disengaged from the second slot, the first movement of the plunger is allowed.

29. The medicament delivery device of claim 16 , further comprising a drive spring configured to move the plunger and the syringe containing the medicament.

30. A medicament delivery device comprising:

a needle for injecting medicament, the needle disposed at a distal end of the medicament delivery device;

a body configured to receive a syringe;

a needle cover axially movable relative to the body between an extended position, in which the needle cover covers the needle, and a retracted position, in which the needle protrudes from a distal end of the needle cover;

a plunger axially movable relative to the body from a proximal position to a distal position to dispense a medicament from the medicament delivery device;

a collar;

a spring configured to bias the collar towards the needle cover to distally bias the needle cover from the retracted position to the extended position; and

a resilient member configured such that when the plunger moves from the proximal position towards the distal position, the resilient member changes from a first configuration in which the spring distally biases the needle cover towards the extended position and a second configuration in which the spring does not distally bias the needle cover towards the extended position.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE INVENTOR NAMES FROM TOM LEVER TO THOMAS LEVER, MIKE PARROTT TO MICHAEL PARROTT, AND ROBBIE WILSON TO ROBERT WILSON PREVIOUSLY RECORDED ON REEL 70345 FRAME 486. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 7, 2025
From: HEE-HANSON, ALEXANDER; LEVER, THOMAS; PARROTT, MICHAEL; WILSON, ROBERT
To: PA HOLDINGS LIMITED
Reel/Frame 072598/0533 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2025
From: HEE-HANSON, ALEXANDER; LEVER, TOM; PARROTT, MIKE; WILSON, ROBBIE
To: PA HOLDINGS LIMITED
Reel/Frame 070345/0486 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2025
From: PA HOLDINGS LIMITED
To: PA CONSULTING SERVICES LIMITED
Reel/Frame 070345/0573 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2025
From: PA CONSULTING SERVICES LIMITED
To: SANOFI-AVENTIS DEUTSCHLAND GMBH
Reel/Frame 070345/0628 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2025
From: SANOFI-AVENTIS DEUTSCHLAND GMBH
To: GENZYME CORPORATION
Reel/Frame 070345/0654 →
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