Granted Patent B2

US 12,296,129 · App. 16/978,385 · Granted May 13, 2025

Inventors: Charles Chabal (Seattle, WA); Peter J. Dunbar (Seattle, WA); Allan Stephan (Seattle, WA); Jack Profit (Seattle, WA)

Assignee: Soovu Labs, Inc.

A61M37/00A61F7/02A61K9/0014A61K31/045A61K31/165A61K31/167A61K31/513A61K36/185A61K41/0052A61K45/06A61F2007/0285A61M2037/0007A61M2205/3303

Abstract

Claims (55)

1. A method of treating pain comprising:

pulsing heat into a volume of tissue including thermoreceptors, wherein—

the pulsed heat is between 42 degrees and 49 degrees Celsius,

the pulsed heat is configured to stimulate the thermoreceptors,

the pulsed heat comprises a heat cycle including a ramp-up phase, a hold phase, and a soak phase,

the ramp-up phase has a duration of about 4 seconds or less,

the hold phase has a duration of about 10 seconds or less, and

the soak phase has a duration of about 20 seconds or less; and

iteratively repeating the heat cycle at a frequency configured to induce and maintain desensitization of at least a subset of the thermoreceptors.

2. The method of claim 1 , wherein the hold phase includes applying heat to the tissue at a temperature between 42 degrees and 49 degrees Celsius.

3. The method of claim 1 , wherein the soak phase includes applying heat at a basal body temperature or not applying heat.

4. The method of claim 1 , wherein the heat cycle is iteratively repeated for a set duration.

5. The method of claim 1 , wherein the heat cycle is configured to desensitize at least a subset of the thermoreceptors.

6. The method of claim 1 , wherein the pulsed heat is configured to stimulate and/or induce desensitization of both warm thermoreceptors and cold thermoreceptors.

7. The method of claim 1 , wherein the pulsed heat is configured to stimulate and/or induce desensitization of TRPV1 receptors.

8. The method of claim 1 , wherein the pulsed heat is configured to stimulate and/or induce desensitization of TRPM8 receptors and/or TRPA1 receptors.

9. The method of claim 1 , wherein the pulsed heat is applied to at least one continuous surface area of the tissue that is 3 square inches or less.

10. The method of claim 1 wherein the duration of the hold phase is about 8 seconds or less.

11. The method of claim 1 wherein the duration of the soak phase is about 10 seconds or less.

12. The method of claim 1 wherein the duration of the hold phase is about 8 seconds or less, and wherein the duration of the soak phase is about 10 seconds or less.

13. A method of treating pain comprising:

applying energy to a volume of tissue including thermoreceptors, wherein—

the applied energy induces a skin temperature between 42 degrees and 49 degrees Celsius,

the applied energy induces a thermal flux in the skin that is below a tissue-damaging threshold,

the applied energy induces stimulation of thermoreceptors,

the applied energy comprises a cycle including a ramp-up phase, a hold phase, and a soak phase,

the ramp-up phase has a duration of about 4 seconds or less,

the hold phase has a duration of about 10 seconds or less, and

the soak phase has a duration of about 20 seconds or less; and

iteratively repeating the cycle at a frequency configured to induce and maintain desensitization of at least a subset of the thermoreceptors.

14. The method of claim 13 , wherein, during the hold phase, energy is applied to the volume of tissue to induce the skin temperature between 42 degrees and 49 degrees Celsius.

15. The method of claim 13 , wherein the soak phase comprises applying no energy to the volume of tissue, and wherein, during the soak phase, the temperature of the skin falls below 42 degrees Celsius.

16. The method of claim 13 , wherein the cycle is iteratively repeated for a set duration.

17. The method of claim 13 , wherein the cycle is configured to desensitize at least a subset of the thermoreceptors.

18. The method of claim 13 , wherein the energy is configured to stimulate and/or induce desensitization of both warm thermoreceptors and cold thermoreceptors.

19. The method of claim 13 , wherein the applied energy is configured to stimulate and/or induce desensitization of TRPV1 receptors.

20. The method of claim 13 , wherein the applied energy is configured to stimulate and/or induce desensitization of TRPM8 receptors and/or TRPMA1 receptors.

21. The method of claim 13 wherein the duration of the hold phase is about 8 seconds or less.

22. The method of claim 13 wherein the duration of the soak phase is about 10 seconds or less.

23. The method of claim 13 wherein the duration of the hold phase is about 8 seconds or less, and wherein the duration of the soak phase is about 10 seconds or less.

24. A system for treating pain, the system comprising:

an energy producing element having a stimulus surface, wherein the stimulus surface is configured to be placed in contact with skin, and wherein the energy producing element is configured to pulse energy into the skin via the stimulus surface,

wherein the pulsed energy comprises a cycle including a ramp-up phase, a hold phase, and a soak phase,

wherein the ramp-up phase has a duration of about 4 seconds or less,

wherein the hold phase has a duration of about 10 seconds or less,

wherein the soak phase has a duration of about 20 seconds or less,

wherein the pulsed energy is configured to stimulate thermoreceptors within the skin, and

wherein the cycle is iteratively repeated at a frequency configured to induce and maintain desensitization of at least a subset of the thermoreceptors.

25. The system of claim 24 , further comprising an electrical circuit configured to monitor the temperature of the skin to ensure that the pulsed energy does not cause an injury to the skin.

26. The system of claim 25 , wherein the electrical circuit is configured to utilize a look-up table, a formula, a chart, or other source of information to predict the characteristic of thermal energy that causes injury to the skin.

27. The system of claim 25 , further comprising a temperature measuring element configured to sense the temperature of the skin.

28. The system of claim 25 , wherein the electrical circuit is configured to transmit monitored characteristics to a control device.

29. The system of claim 28 , wherein the monitored characteristics include the skin's thermal transfer capacity and/or the skin's blood flow.

30. The system of claim 24 , wherein the pulsed energy is configured to induce a skin temperature between 42 degrees and 49 degrees Celsius.

31. The system of claim 24 , wherein the subset of thermoreceptors includes TRPV1, TRPM8, and/or TRPA1.

Assignments (3)

Continuity (2)

References Cited (400)