Granted Patent
B2
US 12,303,564 · App. 17/522,334 · Granted May 20, 2025
Composite chitosan-tannin-active agent compositions and methods of making and using same
Assignee:
Wisconsin Alumni Research Foundation
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Abstract
Composite composition comprising chitosan, tannin, and an active agent and methods of making and using same.
Claims (27)
1. A composite composition comprising chitosan lacking lactate moieties, condensed tannin lacking sulfonate moieties, and an active agent, wherein:
the chitosan lacking lactate moieties has a number average molecular weight of from 125 kDa to 500 kDa;
the tannin lacking sulfonate moieties has a weight average molecular weight of from 100 Da to 10,000 Da;
the chitosan lacking lactate moieties and the tannin lacking sulfonate moieties are present in a weight ratio of the chitosan lacking lactate moieties-to-the tannin lacking sulfonate moieties of from 85:15 to 99:1;
the active agent is selected from the group consisting of serotonin, melatonin, psilocybin, and any combination thereof;
the active agent is present in the composition in an amount of from 0.001 mg to 500 mg;
the composition is in a form of a film; and
the film dissolves in saliva within 4.5 minutes.
2. The composition of claim 1 , wherein the composition dissolves in saliva within 2 minutes.
3. A method of administering an active agent to a subject, the method comprising orally administering the composition of claim 1 to the subject.
4. The method of claim 3 , wherein the administering comprises oral mucosal administration of the composition to the subject.
5. The method of claim 3 , wherein the composition dissolves in a mouth of the subject within 2 minutes.
6. The composition of claim 1 , wherein the chitosan lacking lactate moieties has a number average molecular weight of from 200 Da to 350 kDa.
7. The composition of claim 1 , wherein the chitosan is a fungal chitosan.
8. The composition of claim 1 , wherein the active agent is serotonin.
9. The composition of claim 1 , wherein the active agent is melatonin.
10. The composition of claim 1 , wherein the active agent is psilocybin.
11. The composition of claim 1 , wherein the active agent is present in the composition in an amount of from 0.1 mg to 250 mg.
12. The composition of claim 1 , wherein the active agent is present in the composition in an amount of from 0.1 mg to 30 mg.
13. The composition of claim 1 , wherein the chitosan lacking lactate moieties and the tannin lacking sulfonate moieties are present in a weight ratio of the chitosan lacking lactate moieties-to-the tannin lacking sulfonate moieties of from 85:15 to 95:5.
14. The composition of claim 13 , wherein the chitosan lacking lactate moieties has a number average molecular weight of from 200 Da to 350 kDa.
15. The composition of claim 14 , wherein the chitosan is a fungal chitosan.
16. The composition of claim 15 , wherein the active agent is serotonin.
17. The composition of claim 15 , wherein the active agent is melatonin.
18. The composition of claim 15 , wherein the active agent is psilocybin.
19. The composition of claim 15 , wherein the active agent is present in the composition in an amount of from 0.1 mg to 250 mg.
20. The composition of claim 15 , wherein the active agent is present in the composition in an amount of from 0.1 mg to 250 mg.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 10, 2021
From: REED, JESS; KRUEGER, CHRISTIAN
To: WISCONSIN ALUMNI RESEARCH FOUNDATION
Reel/Frame 058070/0348 →
Continuity (2)
Provisional Application
63163322
· Mar 19, 2021
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