Granted Patent B1

US 12,324,798 · App. 18/977,838 · Granted Jun 10, 2025

Inventors: Weili Fu (Chengdu, CN); Runze Yang (Chengdu, CN); Liwei Yan (Chengdu, CN); Jian Li (Chengdu, CN)

Assignee: WEST CHINA HOSPITAL OF SICHUAN UNIVERSITY

A61K31/235A61K9/06A61K9/5146A61K47/42

Abstract

Claims (9)

1. A preparation method for a leonurine nanocomposite hydrogel, comprising:

step 1: dissolving dopamine (DA) monomers and inducing oxidation and self-polymerization of the DA monomers to obtain polydopamine (PDA) nanoparticles, grafting thiol polyethylene glycol folic acid (SH-PEG-FA) on a surface of the PDA nanoparticles to obtain folic acid polydopamine (FA-PDA) nanocarriers;

step 2: loading a leonurine (Leon) using the FA-PDA nanocarriers of the step 1 to obtain FA-PDA@Leon;

step 3: encapsulating the FA-PDA@Leon of the step 2 into a gel matrix to obtain gel@FA-PDA@Leon hydrogel;

wherein the gel@FA-PDA@Leon hydrogel is prepared by: dissolving gelatin and mixing the gelatin with the FA-PDA@Leon to obtain solution A, adding polyethylene glycol diacrylate (PEGDA) solution to the solution A and adding sodium hydroxide (NaOH) solution to adjust a pH value to obtain the gel@FA-PDA@Leon hydrogel; wherein a mass ratio of the gelatin to the FA-PDA@Leon is 640:1.

2. The preparation method for the leonurine nanocomposite hydrogel of claim 1 , wherein a mass ratio of the FA-PDA nanocarriers to the Leon in the step 2 is 20:1.

3. The preparation method for the leonurine nanocomposite hydrogel of claim 1 , wherein in the step 1, a condition for inducing the oxidation and self-polymerization of the DA monomer is stirring and reacting for 12 hours in Tris solution at 25° C. and pH 8.5.

4. The preparation method for the leonurine nanocomposite hydrogel of claim 1 , wherein the pH value ranges from 6-7.

5. A leonurine nanocomposite hydrogel is obtained by using a preparation method for the leonurine nanocomposite hydrogel of claim 1 .

Assignments (1)

Priority Claims (1)

References Cited (23)