Granted Patent B2

US 12,337,196 · App. 18/480,900 · Granted Jun 24, 2025

Inventors: Debashish Pal (Sunnyvale, CA); Ayan Mitra (Dublin, CA); Christopher Eric Brown (Morgan Hill, CA); Peter Demetri Olcott (Los Gatos, CA); Yevgen Voronenko (San Jose, CA); Rostem Bassalow (Lacey, WA)

Assignee: RefleXion Medical, Inc.

A61N5/1031A61N5/1001A61N5/1045A61N5/1049A61N5/1065A61N5/1067A61N5/1069A61N5/107A61N5/1081A61N2005/1019A61N5/1036A61N5/1039A61N2005/1041A61N5/1075

Abstract

Claims (27)

1. A method for updating a treatment plan fluence map, the method comprising:

acquiring PET imaging data originating from a target region using PET detectors;

identifying a location of the target region from the acquired PET imaging data; and

updating a treatment plan fluence map for irradiating the target region using the identified location, wherein updating the treatment plan fluence map comprises scaling a planned fluence using one or more of a normalization factor, a dampening factor, and a weighting factor.

2. The method of claim 1 , wherein the PET detectors comprise time-of-flight PET detectors.

3. The method of claim 1 , further comprising acquiring MV detector data, and wherein updating the treatment plan fluence map uses the acquired MV detector data.

4. The method of claim 1 , further comprising delivering radiation to the target region according to the updated treatment plan fluence map using a therapeutic radiation source.

5. The method of claim 4 , wherein delivering radiation to the target region comprises adjusting a speed of a couch while the therapeutic radiation source is emitting radiation.

6. The method of claim 1 , wherein delivering radiation occurs in at least two separate passes of a couch through radiation emitted by a therapeutic radiation source.

7. The method of claim 6 , wherein updating the treatment plan fluence map comprises updating the treatment plan fluence map after a first couch pass and updating the treatment plan fluence map after a second couch pass.

8. The method of claim 7 , wherein the normalization factor is dynamically updated for the second couch pass based on radiation delivered during the first couch pass.

9. The method of claim 1 , wherein updating the treatment plan fluence map comprises updating radiotherapy system instructions, wherein radiotherapy system instructions comprise one or more of jaw, multi-leaf collimator, couch, and/or gantry instructions.

10. The method of claim 1 , further comprising calculating a fluence previously delivered to the target region and comparing the previously delivered fluence to the treatment plan fluence map to calculate a fluence difference, and wherein updating the treatment plan fluence map comprises adjusting radiation delivery to deliver the calculated fluence difference.

11. The method of claim 10 , further comprising determining dose artifacts in the previously delivered fluence, and wherein updating the treatment plan fluence map comprises adjusting radiation delivery to correct the dose artifacts.

12. The method of claim 1 , wherein acquiring PET data, identifying the location of the target region, and updating the treatment plan fluence map occur during a single treatment session.

13. The method of claim 1 , wherein the normalization factor and/or dampening factor and/or weighting factor are determined based on an intensity of the PET imaging data originating from the target region.

14. A method for updating a treatment plan fluence map, the method comprising:

acquiring PET imaging data originating from a target region using PET detectors;

calculating a fluence previously delivered to the target region;

comparing the previously delivered fluence to a treatment plan fluence map to determine dose artifacts in the previously delivered fluence; and

updating the treatment plan fluence map by adjusting radiation delivery to correct the dose artifacts.

15. The method of claim 14 , wherein the PET detectors comprise time-of-flight PET detectors.

16. The method of claim 14 , further comprising acquiring MV detector data, and wherein updating the treatment plan fluence map uses the acquired MV detector data.

17. The method of claim 14 , further comprising delivering radiation to the target region according to the updated treatment plan fluence map using a therapeutic radiation source.

18. The method of claim 17 , wherein delivering radiation to the target region comprises adjusting a speed of a couch while the therapeutic radiation source is emitting radiation.

19. The method of claim 17 , wherein delivering radiation occurs in at least two separate passes of a couch through radiation emitted by the therapeutic radiation source.

20. The method of claim 19 , wherein updating the treatment plan fluence map comprises updating the treatment plan fluence map after a first couch pass and updating the treatment plan fluence map after a second couch pass.

Assignments (1)

Continuity (6)

References Cited (378)