IP Library Granted Patent US 12,349,679
Granted Patent B2
US 12,349,679 · App. 17/431,775 · Granted Jul 8, 2025

Combination of pyroglutamic acid and a urease inhibitor for improved plant health effects

Inventors: Darin Lickfeldt (Cary, NC); Amy Burton (Fuquay-Varina, NC); Sandra Paa (Cary, NC); Nicholas William Vandervort, III (Cresco, IA)
A01N57/28A01N43/36A01P21/00
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Quick Facts
Patent No.
US 12,349,679
App. No.
17/431,775
Granted
Jul 8, 2025
Kind
B2
Abstract

The subject matter described herein relates generally to compositions and formulations and methods of use of combinations of pyroglutamic acid and NBPT for improving plant health characteristics, such as crude protein yield and increasing percent nitrogen in plant tissue.

Claims (20)

1. A composition comprising pyroglutamic acid (PGA) and N-(n-butyl)-thiophosphoric triamide (NBPT), wherein the pyroglutamic acid is present in an amount from about 12% w/w to about 36% w/w of the composition and the NBPT is present in an amount from about 13% w/w to about 40% w/w of the composition; and

wherein the pyroglutamic acid and NBPT are present in synergistically effective amounts for increasing percent (%) nitrogen and/or percent (%) phosphorus content in plant tissue.

2. The composition of claim 1 , wherein the pyroglutamic acid is L-pyroglutamic acid.

3. The composition of claim 1 , wherein the pyroglutamic acid is a mixture of L- and D-pyroglutamic acid in a ratio of L to D of from about 80:20 to about 97:3.

4. The composition of claim 1 , further comprising:

(a) soluble potash and a preservative; or

(b) N-methyl-2-pyrrolidone, potassium hydroxide and/or 1,2-propanediol.

5. A method of increasing percent nitrogen of plant tissue compared to an untreated plant, the method comprising applying the composition of claim 1 .

6. The method of claim 5 , wherein said percent nitrogen is increased from about 2% to about 8%.

7. A formulation comprising the composition of claim 1 and an agriculturally acceptable excipient.

8. The formulation of claim 7 , wherein the formulation is a type selected from the group consisting of emulsifiable concentrate, soluble concentrate, oil-in-water emulsion, microemulsion, oil based suspension concentrate, suspension concentrate, and dispersible concentrate.

9. A method of increasing grain crude protein (%) of a plant comprising applying pyroglutamic acid and NBPT to the plant or an area adjacent to the plant,

wherein the pyroglutamic acid is present in an amount from about 12% w/w to about 36% w/w and the NBPT is present in an amount from about 15% w/w to about 35% w/w; and

wherein the pyroglutamic acid and the NBPT are present in synergistically effective amounts for increasing grain crude protein (%) of a plant.

10. The method of claim 9 , wherein the pyroglutamic acid and the NBPT are applied simultaneously as a single composition.

11. The method of claim 9 , wherein the applying comprises contacting PGA at a rate of about 75 g/ha to about 300 g/ha, and NBPT at about 300 g/ha to about 2270 g/ha.

12. The method of claim 9 , wherein said plant is selected from the group consisting of cereals, wheat, barley, oats, triticale, rye, rice, maize, soya beans, potatoes, vegetables, peanuts, cotton, oilseed rape, and fruit plants.

13. The method of claim 9 , wherein crude protein (%) is increased from about 3% to about 25% as compared to an untreated plant.

14. The method of claim 9 , wherein the pyroglutamic acid and the NBPT are in a composition and the composition further comprises potassium hydroxide, soluble potash and a preservative.

15. The method of claim 9 , wherein the pyroglutamic acid is L-pyroglutamic acid; or the pyroglutamic acid is a mixture of L- and D-pyroglutamic acid in a ratio of L to D of from about 80:20 to about 97:3.

Assignments (2)
SECURITY INTEREST Recorded Jan 2, 2026
From: CYTOZYME LABORATORIES, INC.; VERDESIAN LIFE SCIENCES, LLC
To: PNC BANK, NATIONAL ASSOCIATION
Reel/Frame 073352/0317 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2024
From: LICKFELDT, DARIN; BURTON, AMY; PAA, SANDRA; VANDERVORT, NICHOLAS WILLIAM, III
To: VERDESIAN LIFE SCIENCES U.S., LLC
Reel/Frame 067611/0177 →
Continuity (2)
Provisional Application 62809026 · Feb 22, 2019
Related Publication 20220110326A1 · Apr 14, 2022
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