Antimicrobial solutions
View Patent ↗An antimicrobial composition includes an aqueous carrier and a surfactant system. The surfactant system includes a first surfactant including a first polyethylene glycol (PEG) compound with an HLB value of greater than about 10 and less than about 14, and a second surfactant different from the first surfactant, wherein the second surfactant has an HLB value less than about 10.
1. An antimicrobial composition, comprising:
an aqueous carrier present in an amount of about 5 wt % to about 95 wt % based on the total weight of the composition;
a cationic antiseptic present in an amount of about 1 wt % to about 10 wt % based on the total weight of the composition, the cationic antiseptic selected from octenidine, chlorhexidine, polyhexamethylene biguanide, benzalkonium chloride, alexidine dihydrochloride, cetyl pyridinium chloride, salts thereof, and a combination thereof; and
a surfactant system comprising:
a first surfactant present in an amount of about 1 wt % to about 10 wt % based on the total weight of the composition,
the first surfactant selected from PEG alkyl esters, PEG alkyl ethers, PEG alkyl amides, and a combination thereof, wherein each alkyl group has 8 to 22 carbon atoms,
the first surfactant characterized by an HLB value of greater than about 10 and less than about 14, and
a second surfactant present in an amount of about 1 wt % to about 10 wt % based on the total weight of the composition,
the second surfactant comprising a 1,2-dihydroxy group and selected from an alkyl ester, an alkyl ether an alkyl amide, and a combination thereof, wherein each alkyl group has 8 to 22 carbon atoms
the second surfactant characterized by an HLB value less than about 10, wherein the first surfactant and the second surfactant are different.
2. The antimicrobial composition of claim 1 , further comprising a third surfactant characterized by HLB value of greater than about 14 and less than about 18.
3. The antimicrobial composition of claim 2 , wherein the third surfactant is a PEG compound chosen from PEG alkyl esters, PEG alkyl ethers, PEG alkyl amides, and mixtures and combinations thereof, the PEG compounds having an alkyl group independently selected to have 8 to 22 carbon atoms.
4. The antimicrobial composition of claim 1 , wherein the first surfactant comprises 6 to 60 ethylene oxide units.
5. The antimicrobial composition of claim 1 , wherein the first surfactant is selected from PEG 12 glyceryl laurate, PEG 20 glyceryl laurate, PEG 30 glyceryl laurate, PEG 20 glyceryl stearate, PEG 7 cocoate, PEG glyceryl caprate, polyglycerol oleate and a combination thereof.
6. The antimicrobial composition of claim 1 , wherein the composition further comprises an alcohol chosen from benzyl alcohol, phenoxy ethanol, isopropyl alcohol, ethanol, and mixtures and combinations thereof.
7. The antimicrobial composition of claim 6 , wherein the alcohol is present in the composition at about 1 wt % to about 10 wt %, based on the total weight of the composition.
8. The antimicrobial composition of claim 1 , wherein the aqueous carrier comprises at least about 80 wt % water, based on the total weight of the aqueous carrier.
9. The antimicrobial composition of claim 1 , wherein the aqueous carrier comprises glycerol, propylene glycol, polyethylene glycol, pentylene glycol, and mixtures and combinations thereof.
10. The antimicrobial composition of claim 1 , wherein the second surfactant is a monoglyceride, derived from a fatty acid chosen from oleic, linoleic, linolenic, caproic, caprylic, capric, lauric, and mixtures and combinations thereof.
11. The antimicrobial composition of claim 1 , wherein the cationic antiseptic is chosen from octenidine hydrochloride, polyhexamethylene biguanide, chlorhexidine gluconate, and a combination thereof.
12. The antimicrobial composition of claim 1 , wherein the cationic antiseptic is chlorhexidine gluconate.
13. A method of disinfecting a treatment site chosen from skin, hair, mucosae, wounds, and body cavities, the method comprising
applying to the treatment site an antimicrobial composition of claim 1 .
14. The method of claim 13 , wherein the composition reduces microorganisms at the treatment site by at least 2 log orders after 10 seconds.
15. The method of claim 13 , wherein the composition reduces microorganisms at the treatment site by at least 5 log orders after 10 seconds.
16. The method of claim 13 , wherein the composition prevents regrowth of microorganisms at the treatment site for 24 hours.
17. A kit, comprising:
an antimicrobial composition of claim 1 ; and
an applicator for applying the antimicrobial composition to the skin of a patient.