Zwitterionically modified polymers and hydrogels
The present invention is directed to a polymer of Formula (IV): wherein A, X, Q, Y, Z, m 1 , m 2 , m 3 , k 1 , and k 2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III): wherein R″, X 1 , Y 1 , Z 1 , m 4 , m 5 , and m 6 are as described herein, and a polymeric network comprising two or more monomers of Formula (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.
1. A monomer of Formula (III):
wherein
X 1 is absent or is
Y 1 is
Z 1 is
m 4 is 1 to 50;
m 5 is 0 to 10;
m 6 is 1 to 50;
R″ is H or C 1-6 alkyl;
R 4 is C 1-20 alkyl;
R 5 is C 1-20 alkyl; and
R 6 is C 1-20 alkyl,
with the proviso that when X 1 is absent, Y 1 is not
2. The monomer of claim 1 , which has Formula (IIIa):
3. The monomer of claim 1 , which has Formula (IIIb):
4. The monomer of claim 1 , which has Formula (IIIc):
5. The monomer of claim 1 , selected from the group consisting of:
6. A polymeric network comprising crosslinked monomers of Formula (III):
wherein
X 1 is absent or is
Y 1 is
Z 1 is
m 4 is 1 to 50;
m 5 is 0 to 10;
m 6 is 1 to 50;
R″ is H or C 1-6 alkyl;
R 4 is C 1-20 alkyl;
R 5 is C 1-20 alkyl; and
R 6 is C 1-20 alkyl,
with the proviso that when X 1 is absent, Y 1 is not
7. The polymeric network of claim 6 , wherein the crosslinked monomers of the network are the same.
8. The polymeric network of claim 6 , wherein the crosslinked monomers of the network are different.
9. The polymeric network of claim 6 , wherein the monomers are cross-linked with a carboxybetaine diacrylamide cross-linker (CBAAX).
10. A hydrogel comprising the polymeric network of claim 6 .
11. A capsule comprising:
the hydrogel of claim 10 and
a therapeutic agent encapsulated in said hydrogel.
12. The capsule of claim 11 , wherein said therapeutic agent comprises a preparation of cells.
13. The capsule of claim 11 further comprising:
a preparation of cells encapsulated in the hydrogel, wherein the therapeutic agent is an agent that is released from the preparation of cells.
14. The capsule of claim 13 , wherein the preparation of cells comprises a preparation of islets.
15. The capsule of claim 11 , wherein the therapeutic agent is selected from the group consisting of a therapeutic protein, peptide, antibody or binding fragment thereof, antibody mimetic, nucleic acid, small molecule, hormone, growth factor, angiogenic factor, cytokine, anti-inflammatory agents, and any combination thereof.
16. A method of delivering a therapeutic agent to a subject, said method comprising:
administering the capsule according to claim 11 to the subject.
17. The method of claim 16 , wherein said administering comprising:
implanting the capsule into the subject.
18. A method of treating a diabetic subject, said method comprising:
implanting the capsule according to claim 14 into a subject with diabetes.