Systems and methods for delivering microdoses of medication
Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.
1. A medication infusion device comprising a patch pump configured to be removably adhered to a wearer's skin for delivering doses of medication from a cartridge through a transcutaneous portion, the medication infusion device comprising:
a pump housing configured to hold a pump and a controller, the pump housing configured to receive the cartridge; and
a cap housing configured to be locked to the pump housing to lock the cartridge therebetween, the cap housing comprising at least three protrusions radially spaced around a portion of the cap housing configured to receive the cartridge, the at least three protrusions configured to engage corresponding receptacles in the pump housing to lock the cap housing to the pump housing upon rotation of the cap housing relative to the pump housing from an open position to a closed position.
2. The medication infusion device of claim 1 , wherein the at least three protrusions and the corresponding receptacles engage in a manner to resist a continuous pushing force on the cap housing from the cartridge and to remain locked.
3. The medication infusion device of claim 1 , wherein the pump housing is configured to be reusable and the cap housing is configured to be disposable.
4. The medication infusion device of claim 1 , wherein the pump housing comprises a first material and the cap housing comprises a second material, the first material having a greater creep resistance than the second material.
5. The medication infusion device of claim 4 , wherein the first material has a greater thickness than the second material.
6. The medication infusion device of claim 1 , wherein the at least three protrusions are configured to inhibit a rotation greater than 90 degrees.
7. The medication infusion device of claim 1 , wherein the at least three protrusions includes a first protrusion comprises a first portion having a wide engagement slit and a second portion having a narrower engagement slit.
8. The medication infusion device of claim 1 , further comprising an adhesive pad configured to be removably adhered to the wearer's skin to couple the patch pump to the wearer.
9. The medication infusion device of claim 1 , wherein the cap housing comprises a tab and the pump housing comprises a mechanical coupling sized and shaped to receive the tab.
10. The medication infusion device of claim 9 , wherein the mechanical coupling and the tab are configured to rotate upon movement of a pusher of the pump.
11. The medication infusion device of claim 10 , wherein the mechanical coupling and the tab are oriented in a first direction when the pump housing is locked to the cap housing, and
wherein the mechanical coupling and the tab are oriented in a second direction, different from the first direction, when the pump housing is unlocked from the cap housing.
12. The medication infusion device of claim 10 , wherein rotation of the mechanical coupling and the tab is configured to cause a microdosing system in the cap housing to generate the doses of the medication.
13. The medication infusion device of claim 12 , wherein the micro-dosing system comprises a dosing tube configured to receive the medication from the cartridge and a plurality of levers configured to contact the dosing tube to move a predetermined dose of the medication towards the transcutaneous portion.
14. The medication infusion device of claim 1 , wherein the transcutaneous portion comprises a cannula configured to extend into the wearer's skin and having one or more apertures beneath an outer skin layer for delivering the doses of the medication.
15. The medication infusion device of claim 14 , wherein the transcutaneous portion further comprises a needle configured to be fluidically coupled to the cannula.
16. The medication infusion device of claim 1 , wherein the cartridge is a pre-filled cartridge, and
wherein the pump housing and the cap housing, when locked together, completely encase the pre-filled cartridge.
17. The medication infusion device of claim 1 , wherein the medication is insulin.
18. A method for locking a patch pump configured to be removably adhered to a wearer's skin for delivering doses of medication from a cartridge through a transcutaneous portion, the method comprising:
providing a pump housing comprising a pump and a controller;
receiving the cartridge in the pump housing; and
locking a cap housing to the pump housing to lock the cartridge therebetween by rotating the cap housing relative to the pump housing from an open position to a closed position, the cap housing comprising at least three protrusions radially spaced around a portion of the cap housing that receives the cartridge, the at least three protrusions configured to engage corresponding receptacles in the pump housing to lock the cap housing to the pump housing.
19. The method of claim 18 , further comprising adhering the cap housing and the pump housing locked together to the wearer's skin.
20. The method of claim 19 , further comprising, after the adhering, delivering the doses of the medication from the cartridge through the transcutaneous portion to the wearer.