Treatment of non-ocular diseases/disorders by delivery of electromagnetic energy to ocular tissue
A process that provides preventative, protective and therapeutic treatment for non-ocular biological tissues or fluids includes applying a pulsed energy source to an ocular tissue or a target fluid to therapeutically or prophylactically treat the non-ocular tissue or fluid. A pulsed energy source having selected energy parameters may be applied to one or more ocular blood vessel of an individual who has a non-ocular disease/disorder. In accordance with one aspect of the present disclosure, it is determined that an individual has one or more non-ocular disease/disorder or other degenerative disease or is at a risk of developing such a disease, and pulsed electromagnetic energy is applied to an ocular tissue of the individual to therapeutically or prophylactically treat the non-ocular disease/disorder.
1. A method for ameliorating a non-ocular disease/disorder in a subject, comprising:
selecting a patient based on a diagnosis for a non-ocular disease/disorder;
responding to the diagnosis by delivering pulsed electromagnetic energy to at least one ocular blood vessel of the patient to ameliorate at least one symptom of the non-ocular disease/disorder; wherein delivering pulsed electromagnetic energy comprises administering a pulsed low level laser/light therapy (LLLT); wherein the pulsed LLLT treatment comprises stimulating the ocular blood vessel with a sub-threshold laser treatment; and wherein the electromagnetic energy has a wavelength of from about 380 nm to about 11,000 nm; and
applying a second dose of electromagnetic energy at one or more different wavelengths wherein the second dose of electromagnetic energy has one or more wavelengths of from about 193 nm to about 1 mm.
2. The method of claim 1 wherein the pulsed electromagnetic energy comprises electromagnetic energy selected from infrared radiation, near infrared radiation, visible light radiation and combinations thereof.
3. The method of claim 1 wherein the at least one ocular blood vessel comprises a member selected from the group consisting of a retinal blood vessel, a choroidal blood vessel and combinations thereof.
4. The method of claim 1 wherein the at least one ocular blood vessel comprises a member selected from the group consisting of a neuroretinal cell, a serum component, a blood cell, a lymphatic cell, an immune cell or a component thereof, an extracellular molecule, an atom, an ion, and combinations thereof.
5. The method of claim 3 wherein the choroidal blood vessel comprises a choroidal feeding vessel.
6. The method of claim 3 wherein the choroidal blood vessel comprises a choroidal draining vessel.
7. The method of claim 1 wherein the method reduces at least one symptom of the non-ocular disease/disorder.
8. The method of claim 1 wherein the non-ocular disease/disorder is selected from the group consisting of cancer, breast cancer related lymphedema, heart disease, hypertension, metabolic/endocrine disorders, diabetes mellitus, diabetic foot ulcers, diabetic neuropathy, cerebrovascular disorders, spinal cord injuries, obesity, dyslipidemia, liver disease, renal disease, traumatic brain injury, dermatologic disorders, onychomycosis, infections including fungal, drug-resistant infections, microbiome related disorders, immune/complement system disorders, dental disorders, oral mucositis, memory disorders, psychiatric disorders, musculoskeletal disorders, bone disorders, osteoporosis, neurodegenerative diseases, excess subcutaneous adiposity, wound healing, poor exercise performance issues, sperm motility and velocity issues, chronic pain, inflammatory disorders, pulmonary disorders, and other degenerative aging disease or other systemic disorders or such disorder(s) one may be at increased risk of developing.
9. The method of claim 1 wherein the pulsed LLLT treatment has predetermined laser parameters selected from the group consisting of laser manufacturer and type, wavelength and frequency, duty cycle, mode, power, irradiance/power density, fluence/energy density, beam profile, spot size, spot number, laser target and laser pattern, short and ultra-short pulse and envelope on durations and off intervals, repeat and off intervals and durations, pulse train duration and envelope duration, pulse and repetition frequency, envelope and pulse train frequency, dosing frequency, session frequency, ocular delivery device, type of contact lens and lubricating ointment for ocular delivery.
10. The method of claim 9 wherein the pulsed energy parameters are selected and applied to the ocular blood vessel to cause resonant or nonresonant light/phonon/photon interactions with molecules/matter within and/or around the ocular blood vessel or ocular tissue.
11. The method of claim 1 wherein the electromagnetic energy has a wavelength of from about 600 nm to about 1100 nm.
12. The method of claim 1 wherein the first wavelength is about 650 nm and wherein the second wavelength is about 810 nm.
13. The method of claim 1 wherein the sub-threshold laser treatment comprises a duty cycle of from about 0.4% to about 100%.
14. The method of claim 1 wherein the sub-threshold laser treatment comprises a duty cycle of from about 2% to about 25%.
15. The method of claim 1 wherein the sub-threshold laser treatment comprises a power of from about 50 mW to about 2000 mW.
16. The method of claim 1 wherein the sub-threshold laser treatment comprises an irradiance of from about 0.059 W/cm 2 to about 63,000 W/cm 2 .
17. The method of claim 1 wherein the sub-threshold laser treatment comprises an energy density of from about 0.024 J/cm 2 to about 150 J/cm 2 per laser beam.
18. The method of claim 1 wherein the sub-threshold laser treatment comprises a pulse duration of no greater than about 1 ms.
19. The method of claim 1 wherein a micropulse from a laser delivers the pulsed electromagnetic energy.
20. The method of claim 19 wherein the micropulse has a duration of from about 0.1 milliseconds to about 1.0 milliseconds.
21. The method of claim 1 wherein the sub-threshold laser treatment comprises a pulse interval of from about 1.0 ms to about 10.0 ms.
22. The method of claim 1 wherein the method comprises, before delivering the pulsed electromagnetic energy, injecting a dye or other medication, a nanoparticle material, or a biologic material intravenously into the subject.
23. The method of claim 22 wherein the dye is selected from the group consisting of indocyanine green, fluorescein and verteporfin.