IP Library › Granted Patent US 12,440,476
Granted Patent B2
US 12,440,476 · App. 18/778,617 · Granted Oct 14, 2025

Agents that target telomerase reverse transcriptase (TERT) for treating cancer and sensitizing cancer cells to genotoxic therapy

Inventors: Karl A. Scheidt (Evanston, IL); Stephen J. Kron (Chicago, IL); Yue Liu (Chicago, IL)
Assignees: Northwestern University; The University of Chicago
A61K31/4192A61K45/06A61P37/06
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Quick Facts
Patent No.
US 12,440,476
App. No.
18/778,617
Granted
Oct 14, 2025
Kind
B2
Abstract

Disclosed herein are agents that target telomerase reverse transcriptase (TERT) for treating cancer and sensitizing cancer cells to genotoxic therapy. The methods include inhibiting induction of an immunosuppressive factor in a subject in need thereof, the method comprising administering an inhibitor of TERT to the subject.

Claims (9)

1. A method for inhibiting induction of an immunosuppressive factor in a subject in need thereof, the method comprising co-administering an inhibitor of telomerase reverse transcriptase (TERT) and a genotoxic therapy to the subject, wherein the subject has a disease or disorder associated with TERT activity and the subject is administered a non-therapeutic amount of the inhibitor of TERT to treat the disease or disorder associated with TERT activity.

2. The method of claim 1 , wherein the immunosuppressive factor is an immune checkpoint protein, a cytokine, a chemokine, an enzyme, or any combination thereof.

3. The method of claim 2 , wherein the immunosuppressive factor is PD-L1.

4. The method of claim 1 , wherein the genotoxic therapy is a radiotherapy or a chemotherapy.

5. The method of claim 1 , wherein the subject has a cell proliferative disease or disorder, wherein the cell proliferative disease or disorder is a cancer of the (1) adrenal gland, bladder, blood, bone, bone marrow, brain, breast, cervix, gall bladder, ganglia, gastrointestinal tract, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, prostate, skin, testis, thymus, or uterus or (2) the cell proliferative disease or disorder is an adenocarcinoma, a leukemia, a lymphoma, a melanoma, a myeloma, a sarcoma, an embryonal malignancy, or a teratocarcinoma.

6. The method of claim 1 , wherein the inhibitor of TERT is a 3-methylideneoxan-4-one compound or a derivative thereof.

7. The method of claim 6 , wherein the inhibitor of TERT is:

8. The method of claim 1 , wherein the inhibitor of TERT is a reversible inhibitor of TERT.

9. The method of claim 1 , wherein the subject is co-administered an immunotherapy or a molecularly targeted therapy.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2025
From: KRON, STEPHEN J.; LIU, YUE
To: THE UNIVERSITY OF CHICAGO
Reel/Frame 072272/0859 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2025
From: SCHEIDT, KARL A.
To: NORTHWESTERN UNIVERSITY
Reel/Frame 071817/0150 →
Continuity (3)
Continuation PCTUS2023060942 · Jan 19, 2023
Provisional Application 63301036 · Jan 19, 2022
Related Publication 20240374574A1 · Nov 14, 2024
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