Granted Patent B2

US 12,480,708 · App. 17/978,794 · Granted Nov 25, 2025

Inventors: T. Patrick Mullin (Franklin, MA); Ethan P. Mullin (Franklin, MA)

F25D29/005F25D23/028F25D23/065F25B2700/02F25D2323/06F25D2400/36F25D2700/12F25D2700/123

Abstract

Claims (64)

1 . A controlled temperature unit, allowing precise temperature control for drug storage, comprising:

a plurality of walls defining an interior and an exterior;

wherein the plurality of walls includes a rear wall and two side walls;

an insulated chamber within the interior, wherein a door attached to the exterior of the plurality of walls provides access to the insulated chamber;

a plurality of temperature probes within the insulated chamber attached to the plurality of walls;

wherein, a body of each of the plurality of temperature probes is placed within an insulation between an exterior wall surface and an interior wall surface, and a tip of each of the plurality of temperature probes is placed out of the insulation and within an inner side of the interior wall surface;

a plurality of shelves within the insulated chamber attached to the plurality of walls;

a visual display;

a process control unit (PCU), operable to:

receive inputs from the plurality of temperature probes;

process the inputs and output a continuous temperature control for the insulated chamber;

display on the visual display configurable temperature control strategies, trend data for each or a combination of some of the plurality of temperature probes, and a status graphic of the insulated chamber and plurality of temperature probes and allow modification of set point parameters;

record and display, on the visual display, open door events, including a time and duration;

generate and display a performance trend of the plurality of temperature probes during each of the open door events;

track and trend temperature uniformity in the insulated chamber, in support of a validation process;

transfer temperature-control-relevant data to a remote data acquisition system, via a data port; and

in response to an adverse condition being detected:

send a signal to an external relay and initiate an emergency shutoff.

2 . The controlled temperature unit of claim 1 further comprising a second plurality of temperature probes within the insulated chamber attached to each of the plurality of shelves.

3 . The controlled temperature unit of claim 2 further comprising a plurality of terminal strips connected to the second plurality of temperature probes within the insulated chamber defined within the plurality of walls.

4 . The controlled temperature unit of claim 1 wherein the plurality of temperature probes is housed within a plurality of extruded thermowells.

5 . The controlled temperature unit of claim 1 wherein each one of the plurality of temperature probes is removable from the insulated chamber.

6 . The controlled temperature unit of claim 1 wherein each one of the plurality of temperature probes is electrically connected to a controller housed within the plurality of walls of the controlled temperature unit.

7 . The controlled temperature unit of claim 1 further comprising a visual display attached to an exterior surface of one of the plurality of walls.

8 . The controlled temperature unit of claim 7 wherein the visual display is electrically connected to a controller housed within the plurality of walls of the controlled temperature unit.

9 . The controlled temperature unit of claim 1 , further comprising a calibration reference probe.

10 . The controlled temperature unit of claim 1 , further comprising a control probe attached to one of the plurality of walls in the interior of the controlled temperature unit, immersed in a thermal buffer solution.

11 . An automated temperature control system for a controlled temperature unit, the controlled temperature unit comprises:

a plurality of walls defining an interior and an exterior;

an insulated chamber within the interior, wherein a door attached to the exterior of the plurality of walls provides access to the insulated chamber;

a plurality of shelves attached to the interior of the plurality of walls;

a plurality of temperature probes within the insulated chamber attached to the interior of the plurality of walls and attached to the plurality of shelves;

wherein, a body of each of the plurality of temperature probes is placed within an insulation between an exterior wall surface and an interior wall surface, and a tip of each of the plurality of temperature probes is placed out of the insulation and within an inner side of the interior wall surface;

the automated temperature control system comprising:

a controller housed within the plurality of walls of the controlled temperature unit;

the plurality of temperature probes electrically connected to the controller; and

a visual display;

wherein the controller is operable to:

receive inputs from the plurality of temperature probes;

process the inputs and output a continuous temperature control for the insulated chamber;

display on the visual display configurable temperature control strategies, trend data for each or a combination of some of the plurality of temperature probes, and a status graphic of the insulated chamber and plurality of temperature probes and allow modification of set point parameters;

record and display, on the visual display, open door events, including a time and duration;

generate and display a performance trend of the plurality of temperature probes during each of the open door events;

track and trend temperature uniformity in the insulated chamber, in support of a validation process;

transfer temperature-control-relevant data to a remote data acquisition system, via a data port; and

in response to an adverse condition being detected:

send a signal to an external relay and initiate an emergency shutoff.

12 . The automated temperature control system of claim 11 further comprising a compressor electrically connected to the controller.

13 . The automated temperature control system of claim 11 further comprising the exterior relay attached to an exterior surface of one of the plurality of walls of the controlled temperature unit and electrically connected to the controller.

14 . The automated temperature control system of claim 11 wherein the controller is operable to display a temperature of the insulated chamber on the visual display.

15 . The automated temperature control system of claim 11 wherein the controller is operable to record a validation event and display a performance trend for the plurality of temperature probes during the validation event.

16 . The automated temperature control system of claim 11 , wherein the controller is operable to receive and transmit information to the visual display to allow user interaction with a performance of the controlled temperature unit, or a temperature mapping data from the controlled temperature unit, from the plurality of temperature probes.

17 . A controlled temperature unit, allowing precise temperature control for drug storage, comprising:

a plurality of walls defining an interior and an exterior;

wherein the plurality of walls includes a rear wall and two side walls;

an insulated chamber within the interior, wherein a door attached to the exterior of the plurality of walls provides access to the insulated chamber;

a plurality of temperature probes within the insulated chamber attached to the plurality of walls;

wherein, a body of each of the plurality of temperature probes is placed within an insulation between an exterior wall surface and an interior wall surface, and a tip of each of the plurality of temperature probes is placed out of the insulation and within an inner side of the interior wall surface;

a plurality of shelves within the insulated chamber attached to the plurality of walls;

wherein, among the plurality of temperature probes, a first group of five temperature probes is arranged in a plus-sign pattern on the rear wall;

wherein, among the plurality of temperature probes, a second group and a third group of five temperature probes are respectively arranged in an X-shaped pattern on each of the two side walls;

wherein, the first group of five temperature probes is the only temperature probes arranged on the rear wall;

wherein, the second group and the third group of five temperature probes are the only temperature probes arranged on the side walls.

18 . The controlled temperature unit of claim 17 , wherein, among the plurality of temperature probes, one or more fourth groups of five temperature probes are each arranged in an X-shaped pattern, each of the one or more fourth groups of five temperature probes on each of the plurality of shelves, and the one or more fourth groups of five temperature probes are the only probes arranged on the plurality of shelves.

Continuity (1)

References Cited (32)