IP Library › Granted Patent US 12,503,703
Granted Patent B1
US 12,503,703 · App. 19/307,939 · Granted Dec 23, 2025

Composition for regulating production of interfering ribonucleic acid

Inventors: Bradley G. Thompson (Calgary, CA); Jill Thompson (Calgary, CA)
Assignee: Wyvern Pharmaceuticals Inc.
C12N15/117C12N15/86C12N2310/141C12N2750/14143
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Quick Facts
Patent No.
US 12,503,703
App. No.
19/307,939
Granted
Dec 23, 2025
Kind
B1
Abstract

Embodiments of the present disclosure relate to a composition that comprises a recombinant plasmid (RP) with a sequence of nucleic acids. The sequence comprise a start region, an end region and an insert positioned between the start region and the end region. The insert encodes for a sequence of micro interfering ribonucleic acid (miRNA) that may be complementary to a sequence of target messenger RNA (mRNA) that encodes for translation of a target biomolecule. The miRNA can cause the target mRNA to be degraded or inactivated, thereby causing a decrease in bioavailability of the target biomolecule because it is degraded or inactivated by the miRNA, thereby decreasing the bioavailability of the target biomolecule. In some embodiments of the present disclosure, the target biomolecule is an immune checkpoint protein.

Claims (5)

1 . A composition that comprises a recombinant plasmid (RP) that comprises a sequence of nucleotides that is at least 95% identical to the full length of SEQ ID NO: 8, wherein the sequence of nucleotides that is at least 95% identical to the full length of SEQ ID NO: 8 comprises an insert sequence of nucleotides that is 100% identical to the full length of SEQ ID NO: 3.

2 . The composition of claim 1 , wherein the RP is encapsulated in a protein coat, a lipid vesicle, or any combination thereof.

3 . The composition of claim 1 , wherein the RP is encapsulated in a viral vector.

4 . The composition of claim 3 , wherein the viral vector is one of a double stranded DNA virus, a single stranded DNA virus, a single stranded RNA virus, or a double stranded RNA virus.

5 . The composition of claim 3 , wherein the viral vector is an adeno-associated virus.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2025
From: THOMPSON, BRADLEY G.; THOMPSON, JILL
To: WYVERN PHARMACEUTICALS INC.
Reel/Frame 072100/0277 →
Continuity (2)
Continuation 18933499 · Oct 31, 2024
Division 18518177 · Nov 22, 2023
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