IP Library Granted Patent US 12,504,366
Granted Patent B2
US 12,504,366 · App. 18/554,988 · Granted Dec 23, 2025

Diagnostic instruments having multiple illumination sources and methods thereof

Inventors: Rayal Raj Prasad Nalam Venkat (Princeton, NJ); Yao-Jen Chang (Princeton, NJ); Benjamin S. Pollack (Jersey City, NJ); Ankur Kapoor (Plainsboro, NJ)
Assignee: Siemens Healthcare Diagnostics Inc.
G01N21/3577G01N21/33G01N21/359G01N33/487
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,504,366
App. No.
18/554,988
Granted
Dec 23, 2025
Kind
B2
Abstract

A method of operating a diagnostic instrument includes illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first period and capturing a first image of the imaging location illuminated by the first light. The method further includes illuminating the imaging location of the diagnostic instrument with second light having a second spectrum for a second period, the second spectrum being more destructive to a chemical configured to be received in the diagnostic instrument than the first spectrum; and capturing a second image of the imaging location illuminated by the second light. Other methods and diagnostic instruments are disclosed.

Claims (44)

1 . A method of operating a diagnostic instrument, comprising:

illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first illumination period;

capturing a first image of the imaging location illuminated by the first light;

analyzing the first image;

illuminating the imaging location of the diagnostic instrument with second light in response to the analyzing, the second light having a second spectrum for a second illumination period, the second spectrum being more destructive to a chemical received in the diagnostic instrument than the first spectrum; and

capturing a second image of the imaging location illuminated by the second light.

2 . The method of claim 1 , wherein the analyzing comprises identifying one or more items in the first image and determining whether the one or more items will be damaged by exposure to the second light.

3 . The method of claim 1 , wherein the analyzing comprises identifying one or more items in the first image and determining an extent to which the one or more items will be damaged by exposure to the second light.

4 . The method of claim 1 , wherein the analyzing comprises determining the second illumination period.

5 . The method of claim 1 , wherein the first light is infrared light or near infrared light.

6 . The method of claim 1 , wherein the first light includes a wavelength of from 900 nm to 1,100 nm.

7 . The method of claim 1 , wherein the second light is ultraviolet light.

8 . The method of claim 1 , wherein the second light includes a wavelength of from 355 nm to 375 nm.

9 . The method of claim 1 , wherein the second illumination period is about 100 ms.

10 . The method of claim 1 , wherein the imaging location includes a component configured to process a specimen.

11 . The method of claim 1 , comprising receiving a specimen, wherein the specimen is located at the imaging location.

12 . A method of operating a diagnostic instrument, comprising:

illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first illumination period;

capturing a first image of the imaging location illuminated by the first light;

illuminating the imaging location of the diagnostic instrument with second light having a second spectrum for a second illumination period, wherein the second illumination period is less than 150 ms, the second spectrum being more destructive to a chemical received in the diagnostic instrument than the first spectrum; and

capturing a second image of the imaging location illuminated by the second light.

13 . A method of operating a diagnostic instrument, comprising:

illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first illumination period;

capturing a first image of the imaging location illuminated by the first light;

analyzing the first image;

determining, based on the analyzing, a second light to illuminate the imaging location, the second light having a second spectrum, the second spectrum being more destructive to a specimen received in the diagnostic instrument than the first spectrum;

determining, based on the analyzing, a second illumination period that the second light is to illuminate the imaging location, the second illumination period being less than the first illumination period;

illuminating the imaging location with the second light for the second illumination period; and

capturing a second image of the imaging location illuminated by the second light.

14 . The method of claim 13 , wherein the analyzing comprises identifying one or more items in the first image and determining whether the one or more items will be damaged by exposure to the second light.

15 . The method of claim 13 , wherein the analyzing comprises identifying one or more items in the first image and determining an extent to which the one or more items will be damaged by exposure to the second light.

16 . The method of claim 15 , wherein the one or more items are at least one specimen.

17 . The method of claim 13 , wherein the first light is infrared light or near infrared light.

18 . The method of claim 13 , wherein the second light is ultraviolet light.

19 . A diagnostic instrument, comprising:

an imaging location;

a first illumination source configured to illuminate the imaging location with first light having a first spectrum for a first period;

a second illumination source configured to illuminate the imaging location with second light having a second spectrum for a second period, wherein the second spectrum is more destructive to a specimen receivable in the diagnostic instrument than the first spectrum and the second period is less than the first period;

an imaging device configured to capture a first image of the imaging location illuminated by the first light and a second image of the imaging location illuminated by the second light; and

a computer configured to execute instructions to:

analyze the first image;

determine the second spectrum in response to analyzing the first image; and

determine the second period in response to analyzing the first image.

20 . The diagnostic instrument of claim 19 , wherein the computer is configured to identify one or more items in the first image and determine whether the one or more items will be damaged by exposure to the second light.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2023
From: NALAM VENKAT, RAYAL RAJ PRASAD; CHANG, YAO-JEN; KAPOOR, ANKUR
To: SIEMENS MEDICAL SOLUTIONS USA, INC.
Reel/Frame 065877/0205 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2023
From: SIEMENS MEDICAL SOLUTIONS USA, INC.
To: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Reel/Frame 065877/0244 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2023
From: POLLACK, BENJAMIN S.
To: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Reel/Frame 065877/0325 →
Continuity (2)
Provisional Application 63175005 · Apr 14, 2021
Related Publication 20240201083A1 · Jun 20, 2024
References Cited (31)
US 6587575B1 · Windham et al. · 2003 [cited by applicant]
US 7840360B1 · Micheels et al. · 2010 [cited by applicant]
US 9091676B2 · Rule et al. · 2015 [cited by applicant]
US 10140705B2 · Wu et al. · 2018 [cited by applicant]
US 20140293277A1 · Subbiah et al. · 2014 [cited by applicant]
US 20180045654A1 · Park et al. · 2018 [cited by applicant]
US 20200191714A1 · Wissmann et al. · 2020 [cited by applicant]
US 20220196474A1 · Bogacz · 2022 [cited by examiner]
JP 2009008460A · 2009 [cited by applicant]
JP 2018514349A · 2018 [cited by applicant]
JP 2019510963A · 2019 [cited by applicant]
JP 2020513966A · 2020 [cited by applicant]
JP 2021045524A · 2021 [cited by applicant]
WO 2017057077A1 · 2017 [cited by applicant]
WO 2018089935A1 · 2018 [cited by applicant]
WO 2020061365A1 · 2020 [cited by applicant]
WO 2022174241A1 · 2022 [cited by applicant]
PCT International Search Report and Written Opinion dated Jun. 8, 2022 (9 Pages). [cited by applicant]
Jantschitsch, C et al. “Infrared Radiation Confers Resistance to UV-Induced Apoptosis Via Reduction cf DNA Damage and Upregulation of Antiapoptolic Proteins” 1271-1279. Journal of Investigative Dermatology. Online. Nov.… [cited by applicant]
https://en.wikipedia.org/wiki/Beer-Lambert_law. [cited by applicant]
Virkler, K et al. “Analysis of body fluids for forensic purposes: From laboratory testing to non-destructive rapid confirmatory identification at a crime scene” Forensic Science International 188 (2009) 1-17. https://ww… [cited by applicant]
Rehak, N et al. “Photolysis of bilirubin in serum specimens exposed to room lighting” Clin Chim Acta. Jan. 2008 ; 387(1-2): 181-183. doi:10.1016/j.cca.2007.09.019. [cited by applicant]
Meyerstein, W et al. “Effect of Light On Red Blood Cells. the Light Sensitivity of Blood From Different Vertebrate Species” J. Physiol., Jun. 30, 1941; 99, 510-514. [cited by applicant]
https://www.mayocliniclabs.com/specimen/preparation/light-protection.html. [cited by applicant]
Lin, A et al. “Forensic applications of infrared imaging for thedetection and recording of latent evidence” J Forensic Sci., Sep. 2007;52(5):1148-1150. [cited by applicant]
https://pharmaxchange.info/2012/05/ultraviolet-visible-uv-vis-spectroscopy--limitations-and-deviations-of-beer-lambert-law/. [cited by applicant]
https://en.wikipedia.org/wiki/Full-spectrum_photography. [cited by applicant]
Kearse, K “Ultraviolet 365 as an Alternative Light Source for Detection of Blood Serum” J Forensic Sci, Sep. 2020, vol. 65, No. 5: 1716-1721. [cited by applicant]
“Beer-Lambert law.” Wikipedia, Wikimedia Foundation, last modified on Nov. 16, 2021, accessed [Dec. 8, 2021] <https://en.wikipedia.org/wiki/Beer-Lambert_law>. [cited by applicant]
“Light Protecction Tests.” Mayo Clinic Laboratories, accessed [Dec. 8, 2021] <https://www.mayocliniclabs.com/specimen/preparation/light-protection.html>. [cited by applicant]
“Full-spectrum photography.” Wikipedia, Wikimedia Foundation, last modified on Nov. 12, 2018, accessed [Dec. 8, 2021] <https://en.wikipedia.org/wiki/Full-spectrum_photography>. [cited by applicant]