IP Library Granted Patent US 12,564,576
Granted Patent B2
US 12,564,576 · App. 17/998,195 · Granted Mar 3, 2026

Therapeutic agent for vascular disorder

Inventors: Takumi Era (Kumamoto, JP); Sayaka Watanabe (Tokyo, JP); Tomoe Kusayanagi (Tokyo, JP)
Assignee: National University Corporation Kumamoto University
A61K31/436A61P9/14
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Quick Facts
Patent No.
US 12,564,576
App. No.
17/998,195
Granted
Mar 3, 2026
Kind
B2
Abstract

An object is to provide a drug that effectively treats a vascular disorder caused by excessive synthesis and secretion of a type IV collagen protein from a vascular endothelial cell. Provided are [1] a therapeutic agent for a vascular disorder associated with excessive synthesis and secretion of a type IV collagen protein; [2] a therapeutic agent for a disease caused by excessive synthesis and secretion of a type IV collagen protein; [3] a pharmaceutical composition for treatment of a vascular disorder associated with excessive synthesis and secretion of a type IV collagen protein; [4] a pharmaceutical composition for treatment of a disease caused by excessive synthesis and secretion of a type IV collagen protein from a vascular endothelial cell; and [5] an agent that inhibits excessive synthesis and secretion of a type IV collagen protein from a vascular endothelial cell, each of [1] to [5] containing sirolimus as an active ingredient.

Claims (6)

1 . A method for treating a peripheral vascular disorder in a subject in need thereof, the peripheral vascular disorder being associated with excessive synthesis and secretion of a type IV collagen protein expressed by type IV collagen α5 or α6 genes, the method comprising administering a pharmaceutical composition comprising sirolimus as an active ingredient.

2 . The method according to claim 1 , wherein the peripheral vascular disorder has developed due to scleroderma.

3 . The method according to claim 1 , wherein the peripheral vascular disorder is a disorder associated with a condition selected from the group consisting of Raynaud's syndrome, pulmonary hypertension, interstitial lung disease, fibrosis of a digestive system, fibrosis of a kidney, fibrosis of a heart, and other vascular lesions associated with Raynaud's syndrome.

4 . A method for inhibiting excessive synthesis and secretion of a type IV collagen protein expressed by type IV collagen α5 or α6 genes from a vascular endothelial cell, comprising applying sirolimus to the vascular endothelial cell.

5 . The method according to claim 1 , wherein the pharmaceutical composition comprising sirolimus is an oral preparation or a topical preparation.

6 . The method according to claim 1 , wherein the expression of type IV collagen is reduced in peripheral vascular cells of the subject after administering the pharmaceutical composition comprising sirolimus as the active ingredient.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2022
From: ERA, TAKUMI; WATANABE, SAYAKA; KUSAYANAGI, TOMOE
To: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
Reel/Frame 061694/0687 →
Priority Claims (1)
JP 2020-082511 · May 8, 2020 · national
Continuity (1)
Related Publication 20230210828A1 · Jul 6, 2023
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