IP Library › Granted Patent US 12,573,045
Granted Patent B2
US 12,573,045 · App. 18/339,007 · Granted Mar 10, 2026

Candidate determination for spinal neuromodulation

Inventors: Brian W. Donovan (San Jose, CA); Ray M. Baker (San Clemente, CA); Samit Patel (Palo Alto, CA)
Assignee: Relievant Medsystems, Inc.
G06T7/0014A61B5/004A61B5/055A61B5/4824G06T7/0012G16H20/30G16H30/20G06T2207/10081G06T2207/10088G06T2207/10104G06T2207/10108G06T2207/10116G06T2207/20081G06T2207/20084G06T2207/30012
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Quick Facts
Patent No.
US 12,573,045
App. No.
18/339,007
Filed
Jun 21, 2023
Granted
Mar 10, 2026
Kind
B2
Art Unit
2666
USPC
382/131
Abstract

Described herein are various implementations of systems and methods for determining likelihood of a patient favorably responding to a neuromodulation procedure based on a quantitative or objective score or determination based on a plurality of indicators of pain (e.g., chronic low back pain stemming from one or more vertebral bodies or vertebral endplates of a patient). The systems and methods may involve application of artificial intelligence techniques (e.g., trained algorithms, machine learning or deep learning algorithms, and/or trained neural networks).

Claims (34)

1 . A computer-implemented method of quantitatively predicting likelihood that a particular subject would respond favorably to basivertebral nerve ablation to treat back pain, the method comprising:

receiving one or more images of at least a portion of a spine of the particular subject;

applying pre-processing imaging techniques to the one or more images using a trained neural network;

extracting, using the trained neural network, features from the one or more images to identify a plurality of indicators of back pain by analyzing pixel values and spatial relationships within the one or more images;

determining, using the trained neural network, an objective score indicative of a likelihood that the particular subject would respond favorably to basivertebral nerve ablation based on said extracting; and

initiating, a treatment recommendation for basivertebral nerve ablation if the objective score exceeds a predetermined threshold.

2 . The computer-implemented method of claim 1 , wherein the plurality of indicators comprises at least one of: (i) bone marrow intensity changes and (ii) vertebral endplate defects or characteristics of vertebral endplate degeneration.

3 . The computer-implemented method of claim 1 , wherein the plurality of indicators comprises both (i) bone marrow intensity changes and (ii) vertebral endplate defects or characteristics of vertebral endplate degeneration.

4 . The computer-implemented method of claim 1 , wherein the extracting features from the one or more images to identify the plurality of indicators of back pain comprises applying a trained neural network to the one or more images to automatically identify the plurality of indicators of back pain.

5 . The computer-implemented method of claim 1 , wherein the one or more images comprise images obtained from ultrashort time-to-echo (“UTE”) MRI sequenced imaging.

6 . The computer-implemented method of claim 1 , wherein the one or more images comprise images obtained from Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation (“IDEAL”) MRI sequenced imaging.

7 . The computer-implemented method of claim 1 , wherein the one or more images comprise images obtained from fast spin echo MRI sequenced imaging.

8 . The computer-implemented method of claim 1 , wherein the one or more images comprise images obtained from computed tomography (“CT”) imaging.

9 . The computer-implemented method of claim 1 , wherein the one or more images comprise images obtained from positron emission tomography (“PET”) bone imaging.

10 . The computer-implemented method of claim 1 , wherein the one or more images comprises images obtained from X-ray imaging.

11 . The computer-implemented method of claim 1 , wherein determining an objective score comprises quantifying the plurality of indicators based on an extent of the plurality of indicators.

12 . The computer-implemented method of claim 11 , wherein the extent may comprise a quantity, a severity, and/or a spatial assessment.

13 . The computer-implemented method of claim 1 , wherein the plurality of indicators further include one or more of the following:

changes in multifidus muscle characteristics;

bone turnover in SPECT images; and

a pain score obtained for the particular subject.

14 . The computer-implemented method of claim 1 , wherein at least a portion of the method is performed by application of machine learning algorithms.

15 . The computer-implemented method of claim 1 , further comprising displaying an output of the objective score on a display.

16 . A computer-implemented method of quantitatively predicting likelihood that a particular subject would respond favorably to basivertebral nerve ablation to treat chronic low back pain, the method comprising:

receiving one or more magnetic resonance images (MRIs) of at least a lumbosacral region of a spine of the particular subject;

applying pre-processing imaging techniques to the one or more MRIs in order to provide uniformity of the one or more MRIs for feature detection using a trained neural network;

detecting, using the trained neural network, features from the one or more MRIs to identify a plurality of indicators of chronic low back pain by analyzing pixel values and spatial relationships within the one or more MRIs,

wherein the plurality of indicators comprises bone marrow intensity changes and vertebral endplate defects or characteristics of vertebral endplate degeneration;

quantifying the identified plurality of indicators based on an extent of the plurality of indicators, wherein the extent may comprise a quantity, a severity, or a spatial assessment;

determining, using the trained neural network, an objective score indicative of a likelihood that the particular subject would respond favorably to a basivertebral nerve ablation procedure based on said quantifying; and

initiating a treatment recommendation for basivertebral nerve ablation if the objective score exceeds a predetermined threshold.

17 . The computer-implemented method of claim 16 , wherein the detecting features from the one or more MRIs to identify the plurality of indicators of chronic low back pain comprises applying a trained neural network to the one or more images to automatically identify the plurality of indicators of chronic low back pain.

18 . The computer-implemented method of claim 16 , wherein the spatial assessment comprises quantifying prevalence of the plurality of indicators in different locations or regions of a vertebral body or endplate of the lumbosacral region of the spine.

19 . The computer-implemented method of claim 16 , wherein the severity comprises size or volume of the plurality of indicators.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2023
From: DONOVAN, BRIAN W.; BAKER, RAY M.; PATEL, SAMIT
To: RELIEVANT MEDSYSTEMS, INC.
Reel/Frame 064710/0828 →
Continuity (3)
Continuation PCTUS2021072125 · Oct 29, 2021
Provisional Application 63129374 · Dec 22, 2020
Related Publication 20230394668A1 · Dec 7, 2023
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