IP Library Granted Patent US 12,648,569
Granted Patent B2
US 12,648,569 · App. 18/730,185 · Granted Jun 9, 2026

Patent

Inventors: Xue Wang (Guangdong, CN); Jianwen Liang (Guangdong, CN); Xintong Yu (Guangdong, CN); Xiaoqin Ji (Guangdong, CN); Jie Wang (Guangdong, CN); Renyan Liu (Guangdong, CN); Lin Wang (Guangdong, CN); Xianzhi Jiang (Guangdong, CN); Kejing Wang (Guangdong, CN)
Assignee: MOON (GUANGZHOU) BIOTECH CO., LTD.
A01N63/22A01P1/00A01P21/00
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Quick Facts
Patent No.
US 12,648,569
App. No.
18/730,185
Granted
Jun 9, 2026
Kind
B2
Abstract

The Bacillus velezensis M173 was deposited with the Guangdong Microbial Culture Collection Center with a deposit number of GDMCC No. 61434. After being prepared into a seed-coating agent, Bacillus velezensis M173 can promote the growth and germination of plants and significantly improve the control effect on pathogens. Moreover, Bacillus velezensis M173 can relieve the condition of dead seedlings of crops at seedling stage after being applied to the crops. In particular, both pot experiments and field experiments prove that the Bacillus velezensis M173 of the present invention has a significant control effect on fungal and bacterial diseases, in particular, bacterial wilt and stem rot. Therefore, the Bacillus velezensis M173 of the present invention has broad application prospects.

Claims (21)

1 . A composition comprising Bacillus velezensis M173, wherein the Bacillus velezensis M173 was deposited with the Guangdong Microbial Culture Collection Center with a deposit number of GDMCC No. 61434, wherein the composition further comprises an agriculturally or horticulturally acceptable diluent, filler, solvent, spontaneous promoter, carrier, emulsifier, dispersant, preservative, antifreezing agent, thickener, adjuvant, or any combination thereof, and wherein the Bacillus velezensis M173 is freeze-dried.

2 . The composition of claim 1 , wherein the composition further comprises one or more additional biological control agents, one or more chemical agents, or any combination thereof.

3 . The composition according to claim 2 , wherein the one or more additional biological control agents is a bacterium selected from the group consisting of Bacillus, Lactobacillus, Bifidobacterium, Propionibacterium, Streptococcus, Lactococcus, Pediococcus, Enterococcus, Staphylococcus , or any combination thereof; and

the bacterium of the Bacillus is selected from the group consisting of Bacillus velezensis, Bacillus subtilis, Bacillus pumilus, Bacillus coagulans , or any combination thereof.

4 . The composition according to claim 1 , wherein application of the composition improves the survival rate of a plant at seedling stage compared to a plant at seedling stage where the composition is not applied, through one or more features selected from: (1) improving survival rate of the plant when transplanted at seedling stage; (2) promoting plant growth; (3) increasing the yield of plant fruits; (4) promoting the growth of a plant organ; (5) improving the resistance of the plant to a stress environment; (6) improving the resistance of the plant to a pathogen; and (7) any combination of (1)-(6).

5 . The composition of claim 3 , wherein the one or more additional biological control agents is Bacillus pumilus M101, wherein the Bacillus pumilus M101 was deposited with the Guangdong Microbial Culture Collection Center with a deposit number of GDMCC No. 61962.

6 . The composition of claim 5 , wherein the Bacillus velezensis M173 and Bacillus pumilus M101 are mixed to a concentration of 1:5 to 5:1 v/v.

7 . The composition of claim 5 , wherein the composition has an ability to form a biofilm.

8 . A method for preventing and/or treating a plant disease caused by a pathogen, or preventing and/or alleviating plant damage or necrosis caused by a non-pathogen condition, comprising: applying to a plant, plant tissue or plant organ the composition according to claim 1 , wherein the plant organ comprises root, stem, leaf, flower, fruit, and seed.

9 . A method for preventing and/or treating a plant disease caused by a pathogen, or preventing and/or alleviating plant damage or necrosis caused by a non-pathogen condition, comprising: applying to a plant, plant tissue or plant organ the composition according to claim 2 , wherein the plant organ comprises root, stem, leaf, flower, fruit, and seed.

10 . A method for preventing and/or treating a plant disease caused by a pathogen, or preventing and/or alleviating plant damage or necrosis caused by a non-pathogen condition, comprising: applying to a plant, plant tissue or plant organ the composition according to claim 3 , wherein the plant organ comprises root, stem, leaf, flower, fruit, and seed.

11 . The method according to claim 8 , wherein the applying comprises root soaking, foliar spraying, mist spraying, composting, seed soaking, coating, field flooding, drop irrigation of the plant or plant organ, smearing the plant or plant organ, or dripping the plant or plant organ.

12 . The method according to claim 8 , wherein the plant tissue comprises meristem, protective tissue, ground tissue, and conducting tissue.

13 . The method according to claim 8 , wherein the pathogen is selected from Colletotrichum capsici, Botrytis cinerea, Ralstonia solanacearum, Rhizoctonia solani, Fusarium graminearum, Fusarium oxysporum, Athelia rolfsii, Streptomyces scabies, Sclerotium rolfsii, Sclerotinia sclerotiorum, Fusarium oxysporum sp. cucumebrium Owen, Gaeumannomyces critici, Fusarium graminearum, Valsa mali, Glomerella cingulata, Rhizoctonia solani, Pyricularia grisea, Alternaria solani, Exserohilum turcicum, Bipolaria maydis, Phytophthora capsici, Phytophthora nicotianae, Pseudomonas syringae, Xanthomonas campestris, Erwinia carotorora, Xanthomonas campestris, Erwinia carotovora, Botrytis -cirerea cinerea, Phytophthora infestans, Exserohilum turcicum, Bipolaria maydis, Fusarium oxysporum f. sp. niveum, Verticillium dahliae, Fusarium oxysporum f. sp. vasinfectum, Phytophthora capsici, Phytophthora nicotianae , or any combination thereof.

14 . A method for improving the resistance of a plant to a pathogen or stress condition, or promoting plant growth, comprising: applying to the plant, plant tissue or plant organ the composition according to claim 1 , wherein the plant organ comprises root, stem, leaf, flower, fruit, and seed.

15 . A method for improving the resistance of a plant to a pathogen or stress condition, or promoting plant growth, comprising: applying to the plant, plant tissue or plant organ the composition according to claim 2 , wherein the plant organ comprises root, stem, leaf, flower, fruit, and seed.

16 . A method for improving the resistance of a plant to a pathogen or stress condition, or promoting plant growth, comprising: applying to the plant, plant tissue or plant organ the composition according to claim 3 , wherein the plant organ comprises root, stem, leaf, flower, fruit, and seed.

17 . The method according to claim 14 , wherein the pathogen is selected from a pathogenic bacterium, pathogenic fungus or virus.

18 . The method according to claim 14 , wherein the pathogen is selected from the group consisting of Colletotrichum capsici, Botrytis cinerea, Ralstonia solanacearum, Rhizoctonia solani, Fusarium graminearum, Fusarium oxysporum, Athelia rolfsii, Streptomyces scabies, Sclerotium rolfsii, Sclerotinia sclerotiorum, Fusarium oxysporum sp. cucumebrium owen, Gaeumannomyces critici, Fusarium graminearum, Valsa mali, Glomerella cingulata, Rhizoctonia solani, Pyricularia grisea, Alternaria solani, Exserohilum turcicum, Bipolaria maydis, Phytophthora capsici, Phytophthora nicotianae, Pseudomonas syringae, Xanthomonas campestris, Erwinia carotorora, Xanthomonas campestris, Erwinia carotovora, Botrytis -cirerea cinerea, Phytophthora infestans, Exserohilum turcicum, Bipolaria maydis, Fusarium oxysporum f. sp. niveum, Verticillium dahliae, Fusarium oxysporum f. sp. vasinfectum, Phytophthora capsici, Phytophthora nicotianae , and any combination thereof.

19 . The method according to claim 14 , wherein the stress condition is selected from the group consisting of temperature, drought, soil salt content, drug-induced damage, soil hardening, acidic soil, alkaline soil, insufficient soil fertility, and any combination thereof.

20 . The method according to claim 14 , wherein the plant disease caused by the pathogen is selected from the group consisting of bacterial wilt of plants, soft rot of plants, stem rot of plants, or gray mold of plants.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 18, 2024
From: WANG, XUE; LIANG, JIANWEN; YU, XINTONG; JI, XIAOQIN; WANG, JIE; LIU, RENYAN; WANG, LIN; JIANG, XIANZHI; WANG, KEJING
To: MOON (GUANGZHOU) BIOTECH CO., LTD.
Reel/Frame 068026/0571 →
Priority Claims (1)
CN 202210082910.3 · Jan 21, 2022 · national
Continuity (1)
Related Publication 20250169503A1 · May 29, 2025
References Cited (35)
US 20180020676A1 · Taghavi et al. · 2018 [cited by applicant]
US 20210403858A1 · Chen · 2021 [cited by applicant]
CN 107446847A · 2017 [cited by applicant]
CN 107964514A · 2018 [cited by applicant]
CN 108004185A · 2018 [cited by applicant]
CN 108342335A · 2018 [cited by applicant]
CN 109868250A · 2019 [cited by applicant]
CN 110283742A · 2019 [cited by applicant]
CN 111172080A · 2020 [cited by applicant]
CN 111534460A · 2020 [cited by applicant]
CN 112831441A · 2021 [cited by applicant]
CN 113388545A · 2021 [cited by applicant]
CN 113717901A · 2021 [cited by applicant]
CN 114196602A · 2022 [cited by applicant]
EP 2138044A1 · 2009 [cited by applicant]
IN 201611024795A · 2018 [cited by applicant]
KR 20150106093A · 2015 [cited by applicant]
KR 102252856B1 · 2021 [cited by applicant]
TW 202035678A · 2020 [cited by applicant]
TW I740263B · 2021 [cited by applicant]
Wang et al., Effects of Bacillus velezensis FKM10 for Promoting the Growth of Malus hupehensis Rehd. and Inhibiting Fusarium verticillioides, Frontiers in Microbiology, vol. 10, Article 2889, (Jan. 2020), pp. 1-16. [cited by examiner]
Cao et al., Antagonism of Two Plant-Growth Promoting Bacillus velezensis Isolates Against Ralstonia solanacearum and Fusarium oxysporum, Scientific Reports, vol. 8, (2018), pp. 1-14. [cited by examiner]
International Search Report for PCT/CN2023/073307 mailed on Mar. 19, 2023. [cited by applicant]
Office action issued on Apr. 1, 2023 from China Patent Office in a counterpart China Patent Application No. 202210082910.3 (all the cited references are listed in this IDS.) (English translation is also submitted herewi… [cited by applicant]
Office action issued on Oct. 9, 2023 from China Patent Office in a counterpart China Patent Application No. 202210082910.3 (all the cited references are listed in this IDS.) (English translation is also submitted herewi… [cited by applicant]
Notice of Allowance issued on Mar. 13, 2024 from China Patent Office in a counterpart China Patent Application No. 202210082910.3 (all the cited references are listed in this IDS.) (English translation is also submitted… [cited by applicant]
Huang Huijing et al.,“Screening, fermentation condition optimization, and field control effect evaluation of an antagonistic bacterium against Ralstonia solanacearum”, Microbiology China, Feb. 20, 2022, vol. 49, No. 2, … [cited by applicant]
Yuan Xiao-juan et al.,“Study on the Control Effect of Seed Coating Agent Containing Bacillus pumilus on Cotton Fusarium Wilt”, Journal of Xinjiang Agricultural University, 2019, vol. 42, No. 5, pp. 365-371 (English tran… [cited by applicant]
Leiqin Liang et al. , “Genomic, Antimicrobial, and Aphicidal Traits of Bacillus velezensis ATR2, and Its Biocontrol Potential against Ginger Rhizome Rot Disease Caused by Bacillus pumilus”, microorganisms, Dec. 29, 2021… [cited by applicant]
European Search Report issued in counterpart European Patent Application No. EP 23742993.1, dated Jan. 22, 2026. [cited by applicant]
First Office Action issued in counterpart Chinese Patent Application No. 202380013910.0, dated Nov. 13, 2025. [cited by applicant]
Jin et al., Antifungal mechanism of bacillomycin D from Bacillus velezensis HN-2 against Colletotrichum gloeosporioides Penz, Pesticide Biochemistry and Physiology, Academic Press, vol. 163, pp. 102-107, dated Nov. 6, 2… [cited by applicant]
Katsenios et al., Evaluation of Plant Growth Promoting Bacteria Strains on Growth, Yield and Quality of Industrial Tomato, Microorganisms, vol. 9, No. 10, pp. 2099, dated Oct. 1, 2021. [cited by applicant]
Zhang et al., Characteristics of Growth-promotion and Antibiosis by Bacillus amyloliquefaciens L-H15, Transactions of the Chinese Society for Agricultural Machinery, vol. 48, No. 12, pp. 284-291+298, dated Jul. 4, 2017. [cited by applicant]
Zubair et al., Genetic Screening and Expression Analysis of Psychrophilic Bacillus spp. Reveal Their Potential to Alleviate Cold Stress and Modulate Phytohormones in Wheat, microorganisms, vol. 7, pp. 1-25, dated Sep. 1… [cited by applicant]