Altrenogest injection and preparation method and use thereof
Provided are an altrenogest injection and a preparation method and use thereof. The altrenogest injection includes 0.1-35 g altrenogest, 0.01-70 mL of polyethylene glycol, and a balance of an alcohol solvent per 100 mL of the altrenogest injection. The altrenogest injection can effectively inhibit estrus of sows, synchronize the estrus cycle of sows, and is more convenient and efficient to use, and the dosage is more precisely controllable. A single injection can effectively inhibit the estrus of sows for 6 to 12 days, which significantly reduces the labor costs for large-scale farms.
1 . A method of feeding swine, comprising injecting sows with an altrenogest injection to synchronize an estrus cycle of the sows, wherein the altrenogest injection comprises 0.1-35 g altrenogest, 0.01-70 ml of at least one polyethylene glycol, and a balance of at least one alcohol solvent per 100 mL of the altrenogest injection.
2 . The method of feeding swine according to claim 1 , wherein a dose of the altrenogest injection is 0.1-5 mg/kg for each administration.
3 . The method of feeding swine according to claim 2 , wherein the sows are ones that have experienced estrus at least once.
4 . The method of feeding swine according to claim 2 , wherein an injection mode of the altrenogest injection is intramuscular injection or subcutaneous injection.
5 . The method according to claim 1 , wherein the altrenogest injection comprises 1-30 g the altrenogest, 0.1-65 mL of the at least one polyethylene glycol, and a balance of the at least one alcohol solvent per 100 mL of the altrenogest injection.
6 . The method according to claim 5 , wherein the altrenogest injection comprises 5-15 g the altrenogest, 5-30 ml of the at least one polyethylene glycol, and a balance of the at least one alcohol solvent per 100 ml of the altrenogest injection.
7 . The method according to claim 1 , wherein the at least one polyethylene glycol is PEG with a molecular weight less than 700.
8 . The method according to claim 1 , wherein the at least one polyethylene glycol is selected from the group consisting of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 500, and polyethylene glycol 600.
9 . The method according to claim 8 , wherein the at least one polyethylene glycol comprises the polyethylene glycol 400.
10 . The method according to claim 1 , wherein the at least one alcohol solvent is selected from the group consisting of ethanol, 1,2-propanediol, 1,3-propanediol, isopropanol, glycerol, ethylene glycol, benzyl alcohol, phenethyl alcohol, propanol, and dipropylene glycol.
11 . The method according to claim 10 , wherein the at least one alcohol solvent is selected from the group consisting of ethanol, glycerol, isopropanol, and 1,2-propanediol.
12 . The method according to claim 11 , wherein the at least one alcohol solvent consists of ethanol, glycerol, isopropanol, and 1,2-propanediol; and a volume ratio of ethanol, glycerol, isopropanol, and 1,2-propanediol is 1:0.1-1:0.1-1:1-20.