IP Library › Granted Patent US 12,685,803
Granted Patent B2
US 12,685,803 · App. 16/954,322 · Granted Jul 21, 2026

Antimicrobial polymer for use in ophthalmic implants

Inventor: Yichieh Shiuey (San Jose, CA)
A61L27/50A61F2/142A61K9/0024A61K31/785A61L27/16A61L27/18A61L27/26A61L27/54A61L2300/404A61L2430/16
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Quick Facts
Patent No.
US 12,685,803
App. No.
16/954,322
Filed
Jun 16, 2020
Granted
Jul 21, 2026
Kind
B2
Art Unit
1613
USPC
623/5.16
Abstract

An antimicrobial polymer for use in an ophthalmic implant, includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic, silicone, vinyl and collagen monomer.

Claims (7)

1 . An ophthalmic implant comprising an antimicrobial polymer comprising: at least one antimicrobial monomer is a quaternary ammonium salt-based monomer selected from 1-[12-(methacryloyloxy) dodecyl]pyridinium bromide (MDPB), methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), 2-methacryloxyethyl dodecyl methyl ammonium bromide (MAE-DB), 2-methacryloxyethyl hexadecyl methyl ammonium bromide (MAE-HB) or bis(2-methacryloxyethyl) dimethyl ammonium bromide (IDMA-1); and

monomers selected from hydrophobic acrylic monomers or hydrophilic acrylic monomers,

wherein the hydrophobic acrylic monomers are selected from monomers of ethyl acrylate, ethyl methacrylate, 2,2,2-trifluoroethyl methacrylate, cross linked with ethylene glycol dimethacrylate, which form a copolymer of ethyl acrylate, ethyl methacrylate, 2,2,2-trifluoroethyl methacrylate, cross linked with ethylene glycol dimethacrylate; or monomers of phenylethyl methacrylate and n-butyl acrylate, fluoroalkyl methacrylate, which form a cross linked copolymer of phenylethyl methacrylate and n-butyl acrylate, fluoroalkyl methacrylate; and

wherein the hydrophilic acrylic monomers are selected from monomers of hydroxyethyl methacrylate and methyl methacrylate, which form a copolymer of hydroxyethyl methacrylate and methyl methacrylate; monomers of 2-hydroxyethylmethacrylate and 2-ethoxyethylmethacrylate, which form a copolymer of 2-hydroxyethylmethacrylate and 2-ethoxyethylmethacrylate; and monomers of 2-hydroxyethylmethacrylate and methyl methacrylate, which form a copolymer of 2-hydroxyethylmethacrylate and methyl methacrylate.

2 . The antimicrobial polymer according to claim 1 , wherein the antimicrobial polymer is clear, opaque, or translucent.

3 . The antimicrobial polymer according to claim 1 , wherein the antimicrobial polymer is reversibly deformable.

4 . The antimicrobial polymer according to claim 1 , wherein the ophthalmic implant is an artificial cornea, a glaucoma valve, a retinal prosthesis, an intraocular lens, or an intracorneal implant.

Continuity (3)
Continuation In Part 16387465 · Apr 17, 2019
Continuation 15260251 · Sep 8, 2016
Related Publication 20210077249A1 · Mar 18, 2021
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