IP Library › Granted Patent US 12,691,108
Granted Patent B2
US 12,691,108 · App. 16/991,644 · Granted Jul 28, 2026

Methods for treating vascular malformations

Inventors: Daniel L. Flynn (Waltham, MA); Bryan D. Smith (Waltham, MA); Miikka Vikkula (Kraainem, BE)
Assignee: Deciphera Pharmaceuticals, LLC
A61K31/4709A61K45/06A61P9/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,691,108
App. No.
16/991,644
Granted
Jul 28, 2026
Kind
B2
Abstract

The present disclosure relates to methods for inhibiting TIE2 kinase useful in the treatment of growth of venous malformations. Specifically, the disclosure relates to methods of using a compound of Formula I and salts thereof

Claims (15)

1 . A method for reducing the average vascular area of TIE2 kinase-mediated vascular anomalies or TIE2 kinase mutant-mediated vascular anomalies, in a human patient in need thereof, consisting of administering to the patient a pharmaceutical composition comprising a compound of Formula I:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, in an amount sufficient to administer the patient about 25 mg to about 300 mg, once or twice daily, of the compound, wherein the compound is administered to the patient as a single agent.

2 . The method of claim 1 , wherein the pharmaceutically acceptable salt is tosylate.

3 . The method of claim 1 , wherein the TIE2 kinase-mediated vascular anomalies or TIE2 kinase mutant-mediated vascular anomalies are slow-flow malformations.

4 . The method of claim 3 , wherein the slow-flow malformations are selected from capillary malformations, lymphatic malformations, or venous malformations.

5 . The method of claim 4 , wherein the slow-flow malformations are venous malformations.

6 . The method of claim 1 , wherein the patient is administered about 25 mg to about 150 mg of the compound of Formula I once or twice daily.

7 . The method of claim 1 , wherein the patient is administered about 100 mg of the compound of Formula I once or twice daily.

8 . The method of claim 1 , wherein the patient is administered about 150, 200, or 300 mg of the compound of Formula I once or twice daily.

9 . A method for reducing the average vascular area of venous malformations in a human patient in need thereof, consisting of administering to the patient a pharmaceutical composition comprising a compound of Formula I:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, in an amount sufficient to administer the patient about 100 mg to about 200 mg, once or twice daily, of the compound, wherein the compound is administered to the patient as a single agent.

10 . The method of claim 1 , wherein the patient is administered about 25 mg of the compound of Formula I once daily.

11 . The method of claim 1 , wherein the patient is administered about 25mg of the compound of Formula I twice daily.

12 . The method of claim 1 , wherein the patient is administered about 50 mg of the compound of Formula I once daily.

13 . The method of claim 1 , wherein the patient is administered about 50 mg of the compound of Formula I twice daily.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2026
From: FLYNN, DANIEL L.; SMITH, BRYAN D.
To: DECIPHERA PHARMACEUTICALS, LLC
Reel/Frame 075067/0497 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2026
From: VIKKULA, MIIKKA
To: DECIPHERA PHARMACEUTICALS, LLC
Reel/Frame 075067/0809 →
Continuity (3)
Provisional Application 62885519 · Aug 12, 2019
Related Publication 20220047573A1 · Feb 17, 2022
Related Publication 20230277522A9 · Sep 7, 2023
References Cited (400)
US 3528980A · Islip · 1970 [cited by applicant]
US 3818024A · Krenzer · 1974 [cited by applicant]
US 3939122A · Merten et al. · 1976 [cited by applicant]
US 3949002A · Feasey et al. · 1976 [cited by applicant]
US 4093624A · Revankar et al. · 1978 [cited by applicant]
US 4296237A · Cragoe, Jr. et al. · 1981 [cited by applicant]
US 4366189A · Burdeska et al. · 1982 [cited by applicant]
US 4432992A · Cragoe, Jr. et al. · 1984 [cited by applicant]
US 4525450A · Itoh et al. · 1985 [cited by applicant]
US 4816454A · Zoller et al. · 1989 [cited by applicant]
US 5103014A · Musser et al. · 1992 [cited by applicant]
US 5162360A · Creswell et al. · 1992 [cited by applicant]
US 5189045A · Peglion et al. · 1993 [cited by applicant]
US 5319099A · Kamata et al. · 1994 [cited by applicant]
US 5494925A · Court et al. · 1996 [cited by applicant]
US 5514691A · Chan et al. · 1996 [cited by applicant]
US 5621010A · Sueda et al. · 1997 [cited by applicant]
US 5721231A · Moriwaki et al. · 1998 [cited by applicant]
US 5811456A · Seman et al. · 1998 [cited by applicant]
US 6020357A · Pinto et al. · 2000 [cited by applicant]
US 6080763A · Regan et al. · 2000 [cited by applicant]
US 6197599B1 · Chin et al. · 2001 [cited by applicant]
US 6235786B1 · Dai et al. · 2001 [cited by applicant]
US 6294573B1 · Curtin et al. · 2001 [cited by applicant]
US 6319921B1 · Cirillo et al. · 2001 [cited by applicant]
US 6410254B1 · Finer et al. · 2002 [cited by applicant]
US 6500628B1 · Robison · 2002 [cited by applicant]
US 6525046B1 · Cirillo et al. · 2003 [cited by applicant]
US 6645990B2 · Askew et al. · 2003 [cited by applicant]
US 6916924B2 · Tan et al. · 2005 [cited by applicant]
US 7071199B1 · Hirst et al. · 2006 [cited by applicant]
US 7135550B2 · Come et al. · 2006 [cited by applicant]
US 7144911B2 · Flynn et al. · 2006 [cited by applicant]
US 7202257B2 · Flynn et al. · 2007 [cited by applicant]
US 7211575B2 · Moss et al. · 2007 [cited by applicant]
US 7279576B2 · Flynn et al. · 2007 [cited by applicant]
US 7342037B2 · Flynn et al. · 2008 [cited by applicant]
US 7531566B2 · Flynn et al. · 2009 [cited by applicant]
US 7666895B2 · Flynn et al. · 2010 [cited by applicant]
US 7737283B2 · Flynn et al. · 2010 [cited by applicant]
US 7790756B2 · Flynn et al. · 2010 [cited by applicant]
US 7897762B2 · Flynn et al. · 2011 [cited by applicant]
US 8143293B2 · Flynn et al. · 2012 [cited by applicant]
US 8163756B2 · Flynn et al. · 2012 [cited by applicant]
US 8188113B2 · Flynn et al. · 2012 [cited by applicant]
US 8278331B2 · Flynn et al. · 2012 [cited by applicant]
US 8461179B1 · Flynn et al. · 2013 [cited by applicant]
US 8486951B2 · Flynn et al. · 2013 [cited by applicant]
US 8569319B2 · Flynn et al. · 2013 [cited by applicant]
US 8586565B2 · Flynn et al. · 2013 [cited by applicant]
US 8637672B2 · Flynn et al. · 2014 [cited by applicant]
US 8669289B2 · Li · 2014 [cited by examiner]
US 8741911B2 · Allgeier et al. · 2014 [cited by applicant]
US 8921565B2 · Flynn et al. · 2014 [cited by applicant]
US 8940756B2 · Flynn et al. · 2015 [cited by applicant]
US 9012635B2 · Flynn et al. · 2015 [cited by applicant]
US 9133183B2 · Flynn et al. · 2015 [cited by applicant]
US 9181223B2 · Kaufman et al. · 2015 [cited by applicant]
US 9187474B2 · Flynn et al. · 2015 [cited by applicant]
US 9193719B2 · Flynn et al. · 2015 [cited by applicant]
US 9309224B2 · Flynn et al. · 2016 [cited by applicant]
US 9334267B2 · Flynn et al. · 2016 [cited by applicant]
US 9382228B2 · Flynn et al. · 2016 [cited by applicant]
US 9387202B2 · Flynn et al. · 2016 [cited by applicant]
US 9457019B2 · Flynn et al. · 2016 [cited by applicant]
US 10966966B2 · Soto et al. · 2021 [cited by applicant]
US 11103507B2 · Flynn et al. · 2021 [cited by applicant]
US RE48731E · Flynn et al. · 2021 [cited by applicant]
US 20020058678A1 · Cirillo et al. · 2002 [cited by applicant]
US 20020077486A1 · Scarborough et al. · 2002 [cited by applicant]
US 20020165394A1 · Dumas et al. · 2002 [cited by applicant]
US 20020193405A1 · Askew et al. · 2002 [cited by applicant]
US 20030060455A1 · Moss et al. · 2003 [cited by applicant]
US 20030144278A1 · Riedl et al. · 2003 [cited by applicant]
US 20030181442A1 · Riedl et al. · 2003 [cited by applicant]
US 20030216396A1 · Dumas et al. · 2003 [cited by applicant]
US 20040043388A1 · Come et al. · 2004 [cited by applicant]
US 20040067938A1 · Zhang et al. · 2004 [cited by applicant]
US 20040102636A1 · Miller et al. · 2004 [cited by applicant]
US 20040157827A1 · Pevarello et al. · 2004 [cited by applicant]
US 20040167224A1 · Ozaki et al. · 2004 [cited by applicant]
US 20040171075A1 · Flynn et al. · 2004 [cited by applicant]
US 20040180906A1 · Flynn et al. · 2004 [cited by applicant]
US 20050148605A1 · Grotzfeld et al. · 2005 [cited by applicant]
US 20050165024A1 · Milanov et al. · 2005 [cited by applicant]
US 20050165031A1 · Grotzfeld et al. · 2005 [cited by applicant]
US 20050165074A1 · Grotzfeld et al. · 2005 [cited by applicant]
US 20050171171A1 · Mehta et al. · 2005 [cited by applicant]
US 20050171172A1 · Lai et al. · 2005 [cited by applicant]
US 20050192314A1 · Mehta et al. · 2005 [cited by applicant]
US 20050197371A1 · Milanov et al. · 2005 [cited by applicant]
US 20050256174A1 · Wood et al. · 2005 [cited by applicant]
US 20050261315A1 · Mehta et al. · 2005 [cited by applicant]
US 20050267182A1 · Milanov et al. · 2005 [cited by applicant]
US 20050288286A1 · Flynn et al. · 2005 [cited by applicant]
US 20060247186A1 · Carter et al. · 2006 [cited by applicant]
US 20070078121A1 · Flynn et al. · 2007 [cited by applicant]
US 20070179130A1 · Bannen · 2007 [cited by applicant]
US 20070191336A1 · Flynn et al. · 2007 [cited by applicant]
US 20070244120A1 · Dumas et al. · 2007 [cited by applicant]
US 20080009527A1 · Dumas et al. · 2008 [cited by applicant]
US 20080045531A1 · Flynn et al. · 2008 [cited by applicant]
US 20080045706A1 · Flynn et al. · 2008 [cited by applicant]
US 20080090856A1 · Flynn et al. · 2008 [cited by applicant]
US 20080113967A1 · Flynn et al. · 2008 [cited by applicant]
US 20080132506A1 · Flynn et al. · 2008 [cited by applicant]
US 20080187978A1 · Flynn et al. · 2008 [cited by applicant]
US 20080207699A1 · Hoelzemann et al. · 2008 [cited by applicant]
US 20080214545A1 · Lee et al. · 2008 [cited by applicant]
US 20080220497A1 · Flynn et al. · 2008 [cited by applicant]
US 20080221192A1 · Wan et al. · 2008 [cited by applicant]
US 20080248487A1 · Flynn et al. · 2008 [cited by applicant]
US 20080248548A1 · Flynn et al. · 2008 [cited by applicant]
US 20080300281A1 · Dumas et al. · 2008 [cited by applicant]
US 20090069310A1 · Flynn et al. · 2009 [cited by applicant]
US 20090075986A1 · Flynn et al. · 2009 [cited by applicant]
US 20090093526A1 · Miller et al. · 2009 [cited by applicant]
US 20090099190A1 · Flynn et al. · 2009 [cited by applicant]
US 20090105230A1 · Flynn et al. · 2009 [cited by applicant]
US 20090124633A1 · Jonczyk et al. · 2009 [cited by applicant]
US 20090137021A1 · Flynn et al. · 2009 [cited by applicant]
US 20090192307A1 · Michelotti et al. · 2009 [cited by applicant]
US 20090215799A1 · Stieber et al. · 2009 [cited by applicant]
US 20090281089A1 · Gunzner et al. · 2009 [cited by applicant]
US 20090312349A1 · Flynn et al. · 2009 [cited by applicant]
US 20090325945A1 · Niculescu-Duvaz et al. · 2009 [cited by applicant]
US 20100075971A1 · Dumas et al. · 2010 [cited by applicant]
US 20100286215A1 · Pelcman et al. · 2010 [cited by applicant]
US 20110077240A1 · Mannion et al. · 2011 [cited by applicant]
US 20110092461A1 · Gunzner et al. · 2011 [cited by applicant]
US 20110098293A1 · Mannion et al. · 2011 [cited by applicant]
US 20110112193A1 · Nilsson et al. · 2011 [cited by applicant]
US 20110136760A1 · Flynn et al. · 2011 [cited by applicant]
US 20110136809A1 · Lee et al. · 2011 [cited by applicant]
US 20110195110A1 · Smith et al. · 2011 [cited by applicant]
US 20110207752A1 · Geeganage · 2011 [cited by applicant]
US 20120094980A1 · Gunzner et al. · 2012 [cited by applicant]
US 20120114605A1 · Li · 2012 [cited by applicant]
US 20120225057A1 · Flynn et al. · 2012 [cited by applicant]
US 20120270878A1 · Miller et al. · 2012 [cited by applicant]
US 20130071403A1 · Rolland et al. · 2013 [cited by applicant]
US 20130225581A1 · Furuta et al. · 2013 [cited by applicant]
US 20130296326A1 · Pollock · 2013 [cited by applicant]
US 20140179632A1 · Mannion et al. · 2014 [cited by applicant]
US 20140296248A1 · Bernards et al. · 2014 [cited by applicant]
US 20140336210A1 · Carter et al. · 2014 [cited by applicant]
US 20150105550A1 · Gunzner et al. · 2015 [cited by applicant]
US 20150111879A1 · Gunzner et al. · 2015 [cited by applicant]
US 20150133462A1 · Singh et al. · 2015 [cited by applicant]
US 20150218652A1 · Doebele et al. · 2015 [cited by applicant]
US 20150225369A1 · Wucherer-Plietker et al. · 2015 [cited by applicant]
US 20150246033A1 · Flynn et al. · 2015 [cited by applicant]
US 20150275306A1 · Bernards et al. · 2015 [cited by applicant]
US 20150290316A1 · Graziano et al. · 2015 [cited by applicant]
US 20160045532A1 · Roberts et al. · 2016 [cited by applicant]
US 20160152569A1 · Gunzner-Toste et al. · 2016 [cited by applicant]
US 20160289663A1 · Kiyokawa et al. · 2016 [cited by applicant]
US 20170015627A1 · Gunzner-Toste et al. · 2017 [cited by applicant]
US 20170121321A1 · Crews et al. · 2017 [cited by applicant]
US 20170174750A1 · Lim et al. · 2017 [cited by applicant]
US 20170349880A1 · Doucey et al. · 2017 [cited by applicant]
US 20180000771A1 · Inoue et al. · 2018 [cited by applicant]
US 20180015075A1 · Boscolo · 2018 [cited by examiner]
US 20180015175A1 · Kim · 2018 [cited by examiner]
US 20180071302A1 · Abella et al. · 2018 [cited by applicant]
US 20180071303A1 · Abella et al. · 2018 [cited by applicant]
US 20190091217A1 · Flynn et al. · 2019 [cited by applicant]
US 20200129489A1 · Flynn et al. · 2020 [cited by applicant]
US 20200352920A1 · Flynn et al. · 2020 [cited by applicant]
US 20200354346A1 · Flynn et al. · 2020 [cited by applicant]
US 20200354352A1 · Flynn et al. · 2020 [cited by applicant]
US 20210015801A1 · Flynn et al. · 2021 [cited by applicant]
US 20210128556A1 · Flynn et al. · 2021 [cited by applicant]
US 20210145805A1 · Flynn et al. · 2021 [cited by applicant]
US 20210196691A1 · Soto et al. · 2021 [cited by applicant]
US 20210196692A1 · Kaufman et al. · 2021 [cited by applicant]
US 20210196693A1 · Kaufman et al. · 2021 [cited by applicant]
CA 2508917A1 · 2004 [cited by applicant]
CN 106822128A · 2017 [cited by applicant]
CN 108379591A · 2018 [cited by applicant]
DE 1115350B · 1961 [cited by applicant]
DE 4343831A1 · 1995 [cited by applicant]
EP 0021228A1 · 1981 [cited by applicant]
EP 0025232A1 · 1981 [cited by applicant]
EP 0154190A1 · 1985 [cited by applicant]
EP 0661276A1 · 1995 [cited by applicant]
EP 0692483A1 · 1996 [cited by applicant]
EP 0739884A2 · 1996 [cited by applicant]
EP 0867435A1 · 1998 [cited by applicant]
EP 0927555A1 · 1999 [cited by applicant]
EP 928790A1 · 1999 [cited by applicant]
EP 0956855A1 · 1999 [cited by applicant]
EP 1281399A2 · 2003 [cited by applicant]
FR 2337554A1 · 1977 [cited by applicant]
FR 2396549A2 · 1979 [cited by applicant]
GB 971307A · 1964 [cited by applicant]
GB 1410279A · 1975 [cited by applicant]
GB 2220206A · 1990 [cited by applicant]
JP 9221476 · 1997 [cited by applicant]
JP 2000275886A · 2000 [cited by applicant]
JP 20012687A · 2001 [cited by applicant]
JP 5915247B2 · 2016 [cited by applicant]
WO WO199119708A1 · 1991 [cited by applicant]
WO WO199208693A1 · 1992 [cited by applicant]
WO WO199418176A1 · 1994 [cited by applicant]
WO WO199421617A1 · 1994 [cited by applicant]
WO WO199424095A1 · 1994 [cited by applicant]
WO WO199515954A1 · 1995 [cited by applicant]
WO WO199529902A1 · 1995 [cited by applicant]
WO WO199534540A1 · 1995 [cited by applicant]
WO WO199616046A2 · 1996 [cited by applicant]
WO WO199619477A1 · 1996 [cited by applicant]
WO WO199734900A1 · 1997 [cited by applicant]
WO WO199740028A1 · 1997 [cited by applicant]
WO WO199822103A1 · 1998 [cited by applicant]
WO WO199852558A1 · 1998 [cited by applicant]
WO WO199915164A1 · 1999 [cited by applicant]
WO WO199923091A1 · 1999 [cited by applicant]
WO WO199923093A1 · 1999 [cited by applicant]
WO WO199937622A1 · 1999 [cited by applicant]
WO WO199932106A1 · 1999 [cited by applicant]
WO WO199932110A1 · 1999 [cited by applicant]
WO WO199932111A1 · 1999 [cited by applicant]
WO WO199932455A1 · 1999 [cited by applicant]
WO WO199959959A1 · 1999 [cited by applicant]
WO WO200006550A1 · 2000 [cited by applicant]
WO WO200007980A1 · 2000 [cited by applicant]
WO WO200018738A1 · 2000 [cited by applicant]
WO WO200021927A2 · 2000 [cited by applicant]
WO WO200041698A1 · 2000 [cited by applicant]
WO WO2000042012A1 · 2000 [cited by applicant]
WO WO200043384A1 · 2000 [cited by applicant]
WO WO200055139A2 · 2000 [cited by applicant]
WO WO200059506A1 · 2000 [cited by applicant]
WO WO2000071515A2 · 2000 [cited by applicant]
WO WO200112621A1 · 2001 [cited by applicant]
WO WO200114372A2 · 2001 [cited by applicant]
WO WO200174771A1 · 2001 [cited by applicant]
WO WO200196298A2 · 2001 [cited by applicant]
WO WO200200647A1 · 2002 [cited by applicant]
WO WO200214291A1 · 2002 [cited by applicant]
WO WO200214311A2 · 2002 [cited by applicant]
WO WO2002026712A2 · 2002 [cited by applicant]
WO WO200228835A1 · 2002 [cited by applicant]
WO WO200234727A2 · 2002 [cited by applicant]
WO WO2002060869A2 · 2002 [cited by applicant]
WO WO2002060876A1 · 2002 [cited by applicant]
WO WO2002062763A2 · 2002 [cited by applicant]
WO WO2002070662A2 · 2002 [cited by applicant]
WO WO2003005999A2 · 2003 [cited by applicant]
WO WO2003047579A1 · 2003 [cited by applicant]
WO WO2003053368A2 · 2003 [cited by applicant]
WO WO2003059373A2 · 2003 [cited by applicant]
WO WO2003068223A1 · 2003 [cited by applicant]
WO WO2003068229A1 · 2003 [cited by applicant]
WO WO2003072577A1 · 2003 [cited by applicant]
WO WO2003084539A2 · 2003 [cited by applicant]
WO WO2004004720A1 · 2004 [cited by applicant]
WO WO2004056783A1 · 2004 [cited by applicant]
WO WO2004060305A2 · 2004 [cited by applicant]
WO WO2004060306A2 · 2004 [cited by applicant]
WO WO2004061084A2 · 2004 [cited by applicant]
WO WO2004078128A2 · 2004 [cited by applicant]
WO WO2004078746A2 · 2004 [cited by applicant]
WO WO2004113352A1 · 2004 [cited by applicant]
WO WO2005002673A1 · 2005 [cited by applicant]
WO WO2005024755A2 · 2005 [cited by applicant]
WO WO2005034869A2 · 2005 [cited by applicant]
WO WO2005048948A2 · 2005 [cited by applicant]
WO WO2005110994A2 · 2005 [cited by applicant]
WO WO2006014290A2 · 2006 [cited by applicant]
WO WO2006014325A2 · 2006 [cited by applicant]
WO WO2006028958A2 · 2006 [cited by applicant]
WO WO2006039718A2 · 2006 [cited by applicant]
WO WO2006040056A1 · 2006 [cited by applicant]
WO WO2006046552A1 · 2006 [cited by applicant]
WO WO2006052936A2 · 2006 [cited by applicant]
WO WO2006062984A2 · 2006 [cited by applicant]
WO WO2006071940A2 · 2006 [cited by applicant]
WO WO2006072589A2 · 2006 [cited by applicant]
WO WO2006081034A2 · 2006 [cited by applicant]
WO WO2006105844A1 · 2006 [cited by applicant]
WO WO2007008917A2 · 2007 [cited by applicant]
WO WO2007064872A2 · 2007 [cited by applicant]
WO WO2007076473A2 · 2007 [cited by applicant]
WO WO2007081690A2 · 2007 [cited by applicant]
WO WO2007115670A1 · 2007 [cited by applicant]
WO WO2007125330A1 · 2007 [cited by applicant]
WO WO2008033999A2 · 2008 [cited by applicant]
WO WO2008046003A2 · 2008 [cited by examiner]
WO WO2008131227A1 · 2008 [cited by applicant]
WO WO2008131253A1 · 2008 [cited by applicant]
WO WO2008140895A1 · 2008 [cited by applicant]
WO WO2008156712A1 · 2008 [cited by applicant]
WO WO2009030887A2 · 2009 [cited by applicant]
WO WO2009109035A1 · 2009 [cited by applicant]
WO WO2009126863A2 · 2009 [cited by applicant]
WO WO2009127822A2 · 2009 [cited by applicant]
WO WO2009138758A2 · 2009 [cited by applicant]
WO WO2010051373A1 · 2010 [cited by applicant]
WO WO2010124283A2 · 2010 [cited by applicant]
WO WO2011123788A1 · 2011 [cited by applicant]
WO WO2011137342A1 · 2011 [cited by applicant]
WO WO2011139891A1 · 2011 [cited by applicant]
WO WO2011150198A1 · 2011 [cited by applicant]
WO WO2012008563A1 · 2012 [cited by applicant]
WO WO2012019015A2 · 2012 [cited by applicant]
WO WO2012035131A1 · 2012 [cited by applicant]
WO WO2012096832A2 · 2012 [cited by applicant]
WO WO2012097021A1 · 2012 [cited by applicant]
WO WO2012138783A2 · 2012 [cited by applicant]
WO WO2013036232A2 · 2013 [cited by applicant]
WO WO2013043569A1 · 2013 [cited by applicant]
WO WO2013066440A1 · 2013 [cited by applicant]
WO WO2013078295A2 · 2013 [cited by applicant]
WO WO2013134243A1 · 2013 [cited by applicant]
WO WO2013134252A1 · 2013 [cited by applicant]
WO WO2013134298A1 · 2013 [cited by applicant]
WO WO2013177420A2 · 2013 [cited by applicant]
WO WO2013184119A1 · 2013 [cited by applicant]
WO WO2014015056A2 · 2014 [cited by applicant]
WO WO2014032755A2 · 2014 [cited by applicant]
WO WO2014036387A2 · 2014 [cited by applicant]
WO WO2014058317A1 · 2014 [cited by applicant]
WO WO2014071419A2 · 2014 [cited by applicant]
WO WO2014139458A1 · 2014 [cited by applicant]
WO WO2014145004A1 · 2014 [cited by applicant]
WO WO2014145015A2 · 2014 [cited by applicant]
WO WO2014145023A1 · 2014 [cited by applicant]
WO WO2014145025A2 · 2014 [cited by applicant]
WO WO2014145028A2 · 2014 [cited by applicant]
WO WO2014145029A2 · 2014 [cited by applicant]
WO WO2014160183A1 · 2014 [cited by applicant]
WO WO2014182643A2 · 2014 [cited by applicant]
WO WO2015069217A1 · 2015 [cited by applicant]
WO WO2015069266A1 · 2015 [cited by applicant]
WO WO2015076213A1 · 2015 [cited by applicant]
WO WO2015106292A1 · 2015 [cited by applicant]
WO WO2015106294A1 · 2015 [cited by applicant]
WO WO2015148620A2 · 2015 [cited by applicant]
WO WO2015184443A1 · 2015 [cited by applicant]
WO WO2016061228A1 · 2016 [cited by applicant]
WO WO2016061231A1 · 2016 [cited by applicant]
WO WO2016096903A1 · 2016 [cited by applicant]
WO WO2016103223A1 · 2016 [cited by applicant]
WO WO2016114322A1 · 2016 [cited by applicant]
WO WO2016135046A1 · 2016 [cited by applicant]
WO WO2016187157A1 · 2016 [cited by examiner]
WO WO2016196141A1 · 2016 [cited by applicant]
WO WO2017013160A1 · 2017 [cited by applicant]
WO WO2017042944A1 · 2017 [cited by applicant]
WO WO2017079267A1 · 2017 [cited by applicant]
WO WO2017117182A1 · 2017 [cited by applicant]
WO WO2017146794A1 · 2017 [cited by applicant]
WO WO2017146795A1 · 2017 [cited by applicant]
WO WO2017214514A1 · 2017 [cited by applicant]
WO WO2018005737A1 · 2018 [cited by applicant]
WO WO2018052053A1 · 2018 [cited by applicant]
WO WO2018053189A2 · 2018 [cited by applicant]
WO WO2018106595A1 · 2018 [cited by applicant]
WO WO2018195450A1 · 2018 [cited by applicant]
WO WO2018222173A1 · 2018 [cited by applicant]
WO WO2018222644A1 · 2018 [cited by applicant]
Harvey (Molecular Cancer Therapeutics vol. 16 pp. 2486-2501. Published 2017), (Year: 2017). [cited by examiner]
Semones (Bioorganic and Medicinal Chemistry Letters vol. 17 pp. 4756-4760 published 2007) (Year: 2007). [cited by examiner]
Reagan-Shaw (FASEBJ vol. 22 pp. 659-661) published 2007 (Year: 2007). [cited by examiner]
Harney (Molecular Cancer Therapeutics vol. 16 pp. 2486-2501. Published 2017) (Year: 2017). [cited by examiner]
Boscolo (Journal of Clinical Investigation vol. 125 pp. 3491-3504 published 2015) (Year: 2015). [cited by examiner]
U.S. Appl. No. 11/963,740, filed Dec. 21, 2007, Granted, U.S. Pat. No. 8,163,756. [cited by applicant]
U.S. Appl. No. 11/870,388, filed Oct. 10, 2007, Granted, U.S. Pat. No. 7,790,756. [cited by applicant]
U.S. Appl. No. 12/829,561, filed Jul. 2, 2010, Granted, U.S. Pat. No. 8,586,565. [cited by applicant]
U.S. Appl. No. 11/854,354, filed Sep. 12, 2007, Granted, U.S. Pat. No. 8,188,113. [cited by applicant]
U.S. Appl. No. 10/746,460, filed Dec. 24, 2003, Granted, U.S. Pat. No. 7,144,911. [cited by applicant]
U.S. Appl. No. 10/886,329, filed Jul. 6, 2004, Granted, U.S. Pat. No. 7,202,257. [cited by applicant]
U.S. Appl. No. 11/450,840, filed Jun. 9, 2006, Granted, U.S. Pat. No. 7,342,037. [cited by applicant]
U.S. Appl. No. 11/336,708, filed Jan. 20, 2006, Granted, U.S. Pat. No. 7,531,566. [cited by applicant]
U.S. Appl. No. 11/450,850, filed Jun. 9, 2006, Granted, U.S. Pat. No. 7,666,895. [cited by applicant]
U.S. Appl. No. 10/746,607, filed Dec. 24, 2003, Granted, U.S. Pat. No. 7,279,576. [cited by applicant]
U.S. Appl. No. 11/854,293, filed Sep. 12, 2007, Granted, U.S. Pat. No. 7,897,762. [cited by applicant]
U.S. Appl. No. 12/105,408, filed Apr. 18, 2008, Granted, U.S. Pat. No. 8,143,293. [cited by applicant]
U.S. Appl. No. 13/590,955, filed Aug. 21, 2012, Granted, U.S. Pat. No. 8,486,951. [cited by applicant]
U.S. Appl. No. 11/450,849, filed Jun. 9, 2006, Granted, U.S. Pat. No. 7,737,283. [cited by applicant]
U.S. Appl. No. 13/785,575, filed Mar. 5, 2013, Granted, U.S. Pat. No. 8,741,911. [cited by applicant]
U.S. Appl. No. 12/608,578, filed Oct. 29, 2009, Granted, U.S. Pat. No. 8,278,331. [cited by applicant]
U.S. Appl. No. 13/098,247, filed Apr. 29, 2011, Granted, U.S. Pat. No. 8,569,319. [cited by applicant]
U.S. Appl. No. 13/559,170, filed Jul. 26, 2012, Granted, U.S. Pat. No. 8,637,672. [cited by applicant]
U.S. Appl. No. 14/214,134, filed Mar. 14, 2014, Granted, U.S. Pat. No. 9,133,183. [cited by applicant]
U.S. Appl. No. 14/383,803, filed Mar. 5, 2013, Granted, U.S. Pat. No. 9,187,474. [cited by applicant]
U.S. Appl. No. 13/491,394, filed Jun. 7, 2012, Granted, U.S. Pat. No. 8,461,179. [cited by applicant]
U.S. Appl. No. 13/801,753, filed Mar. 13, 2013, Granted, U.S. Pat. No. 8,940,756. [cited by applicant]
U.S. Appl. No. 16/387,315, filed Apr. 17, 2019, Granted, Re. 48731. [cited by applicant]
U.S. Appl. No. 14/214,127, filed Mar. 14, 2014, Granted, U.S. Pat. No. 9,012,635. [cited by applicant]
U.S. Appl. No. 13/683,277, filed Nov. 21, 2012, Granted, U.S. Pat. No. 8,921,565. [cited by applicant]
U.S. Appl. No. 14/549,125, filed Nov. 20, 2014, Granted, U.S. Pat. No. 9,387,202. [cited by applicant]
U.S. Appl. No. 14/214,160, filed Mar. 14, 2014, Granted, U.S. Pat. No. 9,193,719. [cited by applicant]
U.S. Appl. No. 14/214,171, filed Mar. 14, 2014, Granted, U.S. Pat. No. 9,181,223. [cited by applicant]
U.S. Appl. No. 14/214,185, filed Mar. 14, 2014, Granted, U.S. Pat. No. 9,382,228. [cited by applicant]
U.S. Appl. No. 14/214,179, filed Mar. 14, 2014, Granted, U.S. Pat. No. 9,309,224. [cited by applicant]
U.S. Appl. No. 14/383,799, filed Mar. 5, 2013, Granted, U.S. Pat. No. 9,334,267. [cited by applicant]
U.S. Appl. No. 14/535,900, filed Nov. 7, 2014, Granted, U.S. Pat. No. 9,457,019. [cited by applicant]