IP Library Granted Patent US 12,692,502
Granted Patent B2
US 12,692,502 · App. 17/806,138 · Granted Jul 28, 2026

Biological devices and methods of use thereof to produce steviol glycosides

Inventor: Raul Cuero Rengifo (Cypress, TX)
Assignee: Bio Capital Holdings, LLC
C12N15/52C12N9/1022C12N9/1051C12N9/1085C12N9/1205C12N9/88C12N9/90C12N15/8243C12P19/18C12P19/56C12Y202/01007C12Y204/01255C12Y205/01029C12Y207/01001C12Y207/01036C12Y401/01033C12Y503/03002
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Quick Facts
Patent No.
US 12,692,502
App. No.
17/806,138
Filed
Jun 9, 2022
Granted
Jul 28, 2026
Kind
B2
Art Unit
1652
USPC
435/194
Abstract

Described herein are devices and methods for increasing the production of steviol glycosides, which have industrial and economic value. The steviol glycosides produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods and do not have a bitter aftertaste, making them better suited as flavor-enhancing additives to food, pharmaceutical, and nutritional supplement products.

Claims (18)

1 . A vector comprising a DNA construct comprising the following genetic components:

a) a gene that expresses hexokinase having SEQ ID NO: 2 or at least 90% homology thereto;

b) a gene that expresses geranylgeranyl pyrophosphate synthase 2 having SEQ ID NO: 4 or at least 90% homology thereto;

c) a gene that expresses 1-deoxy- D -xylulose-5-phosphate synthase having SEQ ID NO: 5 or at least 90% homology thereto;

d) a gene that expresses mevalonate-5-kinase having SEQ ID NO: 6 or at least 90% homology thereto;

e) a gene that expresses isopentenyl pyrophosphate isomerase having SEQ ID NO: 7 or at least 90% homology thereto;

f) a gene that expresses mevalonate pyrophosphate decarboxylase having SEQ ID NO: 8 or at least 90% homology thereto; and

g) a gene that expresses UDP-glycosyltransferase 76G1 having a His 155Leu mutation and SEQ ID NO: 12 or at least 90% homology thereto;

wherein the vector is a plasmid.

2 . The vector of claim 1 , wherein the DNA construct further comprises a gene that expresses a heat shock protein.

3 . The vector of claim 2 , wherein the gene that expresses a heat shock protein expresses HSP70.

4 . The vector of claim 3 , wherein the gene that expresses HSP70 is SEQ ID NO: 3 or at least 70% homology thereto.

5 . The vector of claim 1 , wherein the DNA construct comprises from 5′ to 3′ the following genetic components in the following order: (a) the gene that expresses mevalonate-5-kinase; (b) the gene that expresses isopentenyl pyrophosphate isomerase; (c) the gene that expresses mevalonate pyrophosphate decarboxylase; (d) the gene that expresses hexokinase; (e) a gene that expresses HSP70; (f) the gene that expresses geranylgeranyl pyrophosphate synthase 2; (g) the gene that expresses a UDP-glycosyltransferase; and (h) the gene that expresses 1-deoxy- D -xylulose-5-phosphate synthase.

6 . The vector of claim 1 , wherein the vector has SEQ ID NO: 14.

7 . The vector of claim 1 , wherein the plasmid is pWLneo, pSV2cat, pOG44, pXT1, pSG, pSVK3, pBSK, pBSKII, pYES, pYES2, pUC, or pUC19.

8 . A biological device comprising host cells transformed with the vector of claim 1 .

9 . A method for producing one or more steviol glycosides comprising growing the biological device of claim 8 for a time sufficient to produce the steviol glycoside.

10 . A method for producing one or more steviol glycosides from plant cells, the method comprising contacting the plant cells with the biological device claim 8 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2023
From: RENGIFO, RAUL CUERO
To: INTERNATIONAL PARK OF CREATIVITY
Reel/Frame 063072/0306 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2023
From: INTERNATIONAL PARK OF CREATIVITY
To: BIO CAPITAL HOLDINGS, LLC
Reel/Frame 063072/0418 →
Continuity (4)
Continuation 16646217 · Sep 10, 2018
Provisional Application 62687284 · Jun 20, 2018
Provisional Application 62557220 · Sep 12, 2017
Related Publication 20230212588A1 · Jul 6, 2023
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