Granted Patent B2

US 12,694,483 · App. 18/416,567 · Granted Jul 28, 2026

Inventors: Abhinav Kumar Jha (St. Louis, MO); Md Ashequr Rahman (St. Louis, MO); Zitong Yu (St. Louis, MO); Barry Siegel (St. Louis, MO)

Assignee: Washington University

G06T5/70G06T7/0012G06T2207/10108G06T2207/20081

Abstract

Claims (29)

1 . A system for single-photon emission computed tomography (SPECT) comprising a computer device comprises at least one processor in communication with at least one memory device, wherein the at least one processor is programmed to:

store a model trained to denoise computer tomography (CT) scans of a subject being examined, wherein the at least one processor is further programmed to train the model with a plurality of historical low-dose CT scans and a plurality of normal dose CT scans, wherein the plurality of historical low-dose CT scans are images of where the corresponding subject received a lower dose of a radioactive tracer than subjects of the normal dose CT scans;

receive a CT scan of a first subject being examined;

execute the model with the CT scan of the first subject as an input, wherein the model performs denoising on the CT scan while accounting for an observer loss function; and

output a denoised-CT scan of the first subject.

2 . The system of claim 1 , wherein the lower dose is one of 12.5% and 6.25% of a normal dose.

3 . The system of claim 1 , wherein the at least one processor is further programmed to execute the model for a plurality of CT scans.

4 . The system of claim 3 , wherein the plurality of CT scans is a part of a video.

5 . The system of claim 1 , wherein the CT scan was taken during a myocardial perfusion.

6 . The system of claim 1 , wherein the at least one processor is further programmed to train the model with an observer loss function.

7 . A method for single-photon emission computed tomography (SPECT), the method implemented by a computer device comprising at least one processor in communication with one or more memory devices, the method comprises:

storing a model trained to denoise computer tomography (CT) scans of a subject being examined;

receiving a CT scan of a first subject being examined, wherein the at least one processor is further programmed to train the model with a plurality of historical low-dose CT scans and a plurality of normal dose CT scans, wherein the plurality of historical low-dose CT scans are images of where the corresponding subject received a lower dose of a radioactive tracer than subjects of the normal dose CT scans;

executing the model with the CT scan of the first subject as an input, wherein the model performs denoising on the CT scan while accounting for an observer loss function; and

outputting a denoised-CT scan of the first subject.

8 . The method of claim 7 , wherein the lower dose is one of 12.5% and 6.25% of a normal dose.

9 . The method of claim 7 further comprising executing the model for a plurality of CT scans.

10 . The method of claim 9 , wherein the plurality of CT scans is a part of a video.

11 . The method of claim 7 , wherein the CT scan was taken during a myocardial perfusion.

12 . The method of claim 7 further comprising training the model with an observer loss function.

13 . A computer device for single-photon emission computed tomography (SPECT) comprising at least one processor in communication with at least one memory device, wherein the at least one processor is programmed to:

store a model trained to denoise computer tomography (CT) scans of a subject being examined, wherein the at least one processor is further programmed to train the model with a plurality of historical low-dose CT scans and a plurality of normal dose CT scans, wherein the plurality of historical low-dose CT scans are images of where the corresponding subject received a lower dose of a radioactive tracer than the subjects of normal dose CT scans;

receive a CT scan of a first subject being examined;

execute the model with the CT scan of the first subject as an input, wherein the model performs denoising on the CT scan while accounting for an observer loss function; and

output a denoised-CT scan of the first subject.

14 . The computer device of claim 13 , wherein the lower dose is one of 12.5% and 6.25% of a normal dose.

15 . The computer device of claim 13 , wherein the at least one processor is further programmed to execute the model for a plurality of CT scans.

16 . The computer device of claim 15 , wherein the plurality of CT scans is a part of a video.

17 . The computer device of claim 13 , wherein the CT scan was taken during a myocardial perfusion.

Assignments (1)

Continuity (2)

References Cited (54)