Crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane and methods of making and using the same
Aspects of the disclosure include crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane. Methods for preparing the crystalline solids of 3-palmitoyl-amido-1,2-propanediol and single crystals of 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane are also provided. Methods for preparing a 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane from a crystalline solid of 3-palmitoyl-amido-1,2-propanediol are also described.
1 . A crystalline solid of a compound of Formula II
wherein DMTr is dimethoxytriphenylmethyl;
each unit cell in the crystalline solid comprises conformer A and conformer B of the compound of Formula II; and conformer A has the atomic coordinates and equivalent isotropic displacement parameters:
O1A
0.8579(3)
0.7210(3)
0.75600(12)
0.0408(9)
N1A
0.0410(5)
0.8405(4)
0.75844(15)
0.0504(13).
2 . The crystalline solid of claim 1 , wherein conformer B has the atomic coordinates and equivalent isotropic displacement parameters:
O1B
0.3551(4)
0.8951(3)
0.74538(15)
0.0585(12)
N1B
0.5490(4)
0.7896(3)
0.76518(12)
0.0331(9).
3 . The crystalline solid of claim 1 , wherein conformer A has the atomic coordinates and equivalent isotropic displacement parameters set forth in Table 2.
4 . The crystalline solid of claim 1 , wherein conformer B has the atomic coordinates and equivalent isotropic displacement parameters set forth in Table 2.