IP Library Granted Patent US 12,703,699
Granted Patent B2
US 12,703,699 · App. 17/801,410 · Granted Aug 11, 2026

Inhibitors of human immunodeficiency virus replication

Inventors: Eric P. Gillis (Branford, CT); Christiana Iwuagwu (Wallingford, CT)
Assignee: VIIV HEALTHCARE UK (NO. 5) LIMITED
C07D471/04A61K9/0053A61K9/0019
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Quick Facts
Patent No.
US 12,703,699
App. No.
17/801,410
Filed
Aug 22, 2022
Granted
Aug 11, 2026
Kind
B2
Art Unit
1691
USPC
514/303
Abstract

A compound of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:

Claims (10)

1 . A compound or salt selected from the group consisting of:

and pharmaceutically acceptable salts thereof.

2 . A pharmaceutical composition comprising a compound or salt according to claim 1 .

3 . A composition according to claim 2 further comprising a pharmaceutically acceptable excipient.

4 . A composition according to claim 2 or claim 3 suitable for oral administration, for intramuscular injection, or for subcutaneous injection.

5 . A method of treating HIV infection in a human comprising administration of a compound or salt according to claim 1 .

6 . The method of claim 5 wherein said administration is oral.

7 . The method of claim 5 wherein said administration is intramuscular injection or subcutaneous injection.

8 . The method of claim 5 wherein said method further comprises administration of at least one other agent used for treatment of AIDS or HIV infection in a human.

9 . The method of claim 8 wherein said at least one other agent is selected from the group consisting of dolutegravir, bictegravir, lamivudine, fostemsavir, and cabotegravir.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2022
From: GILLIS, ERIC P.; IWUAGWU, CHRISTIANA
To: VIIV HEALTHCARE UK (NO.5) LIMITED
Reel/Frame 060858/0600 →
Continuity (2)
Provisional Application 62985946 · Mar 6, 2020
Related Publication 20230106880A1 · Apr 6, 2023
References Cited (31)
US 10954252B1 · Babu et al. · 2021 [cited by applicant]
US 11919897B2 · Iwuagwu et al. · 2024 [cited by applicant]
US 12129255B2 · Gillis et al. · 2024 [cited by applicant]
US 20230149408A1 · Parcella et al. · 2023 [cited by applicant]
US 20230355626A1 · Gillis et al. · 2023 [cited by applicant]
US 20240374598A1 · Bowsher et al. · 2024 [cited by applicant]
US 20250019383A1 · Gillis et al. · 2025 [cited by applicant]
WO WO2014134566A2 · 2014 [cited by applicant]
WO WO2018203235A1 · 2018 [cited by applicant]
WO WO2019198024A1 · 2019 [cited by applicant]
WO WO2020031112A1 · 2020 [cited by applicant]
WO WO2020058844A1 · 2020 [cited by applicant]
WO WO2020089778A1 · 2020 [cited by applicant]
WO WO2020095176A1 · 2020 [cited by applicant]
WO WO2020095177A1 · 2020 [cited by applicant]
WO WO2020157692A1 · 2020 [cited by applicant]
WO WO2020254985A1 · 2020 [cited by applicant]
WO WO2021116872A1 · 2021 [cited by applicant]
Third Party Observations from Corresponding EP Application No. 21711369.5-1110, dated Jul. 6, 2022. [cited by applicant]
Annex to Third Party Observations from Corresponding EP Application No. 21711369.5-1110, Sep. 6, 2022, XP093105865. [cited by applicant]
Swallow Steve, Progress in Medicinal Chemistry, 2015 , 54, pp. 97-165, XP093052381. [cited by applicant]
Eric P. Gillis et al., Journal of Medicinal Chemistry, 58 (21 ), 2015, pp. 8315-8359, XP093035727. [cited by applicant]
Peter W. Glunz, Bioorg. Med. Chem. Lett. 28 (2), 2017, pp. 53-60, XP085314564. [cited by applicant]
Steven R LaPlante et al., ChemMedChem, 6 (3), 2011, pp. 505-513, XP072417599. [cited by applicant]
International Preliminary Report on Patentability for International Application No. PCT/IB2021/051764, mailed Sep. 15, 2022, 11 Pages. [cited by applicant]
International Preliminary Report on Patentability for International Application No. PCT/IB2021/051765, mailed Sep. 15, 2022, 7 Pages. [cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/IB2021/051764, mailed May 12, 2021, 13 Pages. [cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/IB2021/051765 mailed Apr. 15, 2021, 8 Pages. [cited by applicant]
Mcarthur C., et al., “HIV Capsid Inhibitors Beyond PF74,” Diseases, 2019, vol. 7, No. 4, 56, 10 Pages, DOI:10.3390/diseases7040056, XP055800186. [cited by applicant]
Patani G.A., et al., “Bioisosterism: A Rational Approach in Drug Design,” Chemical Reviews, 1996, vol. 96, No. 8, pp. 3147-3176. [cited by applicant]
Swallow S., “Fluorine in Medicinal Chemistry,” Progress in Medicinal Chemistry, 2015, vol. 54, pp. 65-133. [cited by applicant]