Granted Patent B2

US 12,722,010 · App. 18/503,504 · Granted Sep 1, 2026

Inventors: Steven L. Waldhauser (Savage, MN); Steven D. Goedeke (Forest Lake, MN)

Assignee: Cardionomix, Inc.

A61N1/36114A61B5/28A61N1/025A61N1/05A61N1/056A61N1/36139A61B5/01A61B5/0215A61B5/14503A61B5/14532A61B5/14542A61B5/6869A61B7/023A61B2560/0223A61B2562/0219

Abstract

Claims (33)

1 . A method of parameter selection, the method comprising:

delivering a first series of electrical signals to an electrode,

the first series comprising a first plurality of electrical signals,

each of the first plurality of electrical signals comprising a plurality of parameters,

each of the first plurality of electrical signals of the first series differing from one another by a magnitude of a first parameter of the plurality of parameters, wherein the first parameter is a first member of a hierarchy for selecting parameters defining an order in which parameters are to be selected;

receiving first sensor data indicative of heart activity in response to delivering the first series of electrical signals;

selecting a magnitude of the first parameter based on a comparison of the first sensor data to determine which magnitude of the first parameter provides a desired heart activity response;

after delivering the first series of electrical signals to the electrode, delivering, via a stimulation system, a second series of electrical signals to the electrode,

the second series comprising a second plurality of electrical signals,

each of the second plurality of electrical signals comprising the plurality of parameters, wherein each of the second plurality of electrical signals includes the selected magnitude of the first parameter,

each of the second plurality of electrical signals of the second series differing from one another by a magnitude of a second parameter of the plurality of parameters,

the second parameter different than the first parameter; selecting a magnitude of the second parameter, wherein the second parameter is a second member of the hierarchy;

receiving second sensor data indicative of heart activity in response to delivering the second series of electrical signals;

selecting a magnitude of the second parameter based on a comparison of the second sensor data to determine which magnitude of the second parameter provides a desired heart activity response; and

determining a therapeutic neuromodulation signal to be delivered, the therapeutic neuromodulation signal including the selected magnitude of the first parameter and the selected magnitude of the second parameter.

2 . The method of claim 1 , wherein the first parameter comprises one of current, frequency, or duty cycle, and wherein the second parameter comprises a different one of current, frequency, or duty cycle.

3 . The method of claim 1 , wherein the first parameter is one of the following: a polarity, a pulsing mode, a pulse width, an amplitude, a frequency, a phase, a voltage, a current, a duration, an inter-pulse interval, a duty cycle, a dwell time, a sequence, a wavelength, or a waveform, and wherein the second parameter is a different one of the following: a polarity, a pulsing mode, a pulse width, an amplitude, a frequency, a phase, a voltage, a current, a duration, an inter-pulse interval, a duty cycle, a dwell time, a sequence, a wavelength, or a waveform.

4 . The method of claim 1 , wherein the first sensor data and the second sensor data are received from a sensor positioned in a body cavity.

5 . The method of claim 4 , wherein the first sensor data and the second sensor data comprise at least one of a pressure property, an acceleration property, an acoustic property, a temperature, or a blood chemistry property.

6 . The method of claim 1 , wherein the electrode is positioned in a blood vessel.

7 . The method of claim 1 , further comprising:

after delivering the second series of electrical signals to the electrode, delivering, via the stimulation system, a third series of electrical signals to the electrode,

the third series comprising a third plurality of electrical signals,

each of the third plurality of electrical signals comprising the plurality of parameters, wherein each of the third plurality of electrical signals includes the selected magnitude of the first parameter and the selected magnitude of the second parameter,

each of the third plurality of electrical signals of the third series differing from one another by a magnitude of a third parameter of the plurality of parameters,

the third parameter different than the first parameter and the second parameter, wherein the third parameter is a third member of the hierarchy;

receiving third sensor data indicative of heart activity in response to delivering the third series of electrical signals;

selecting a magnitude of the third parameter based on a comparison of the third sensor data to determine which magnitude of the third parameter provides a desired heart activity response; and

wherein the therapeutic neuromodulation signal includes the selected magnitude of the third parameter.

8 . The method of claim 7 , wherein the first sensor data, the second sensor data, and the third sensor data are received from a sensor positioned in a body cavity, wherein the first sensor data, the second sensor data, and the third sensor data comprise at least one of a pressure property, an acceleration property, an acoustic property, a temperature, or a blood chemistry property, and wherein the electrode is positioned in a blood vessel.

9 . The method of claim 1 , wherein the desired heart activity response comprises increased heart contractility.

10 . The method of claim 1 , wherein the comparison comprises an iterative method comprising making comparisons until a limit is found at which a difference is negligible.

11 . The method of claim 1 , wherein the first parameter comprises current and the second parameter comprises frequency.

Assignments (3)

Continuity (4)

References Cited (400)