IP Library › Granted Patent US 12,743,753
Granted Patent B1
US 12,743,753 · App. 18/462,122 · Granted Sep 22, 2026

Masking model for visualizing uncertainty in image-to-image reconstruction

Inventors: Daniel Freedman (Zikhron Yaaqov, IL); Regev Cohen (Tel Aviv, IL); Gilad Kutiel (Zichron Yakov, IL); Michael Elad (Kiriat Tivon, IL)
Assignee: Verily Health Inc.
G06T5/77G06T3/4046G06T3/4053G06T7/0012G06T11/10G16H30/40G06T2207/20081G06T2207/20084G06T2207/30004G06T2210/41
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Quick Facts
Patent No.
US 12,743,753
App. No.
18/462,122
Granted
Sep 22, 2026
Kind
B1
Abstract

Methods and systems of processing medical image data are presented herein. Some methods may include the steps of: receiving image data representing at least one medical image; generating a reconstructed image based on the image data; generating a mask from the image data and the reconstructed image using a pre-trained machine learning model; and applying the mask to the reconstructed image to generate a masked reconstructed image. The mask may include at least three uncertainty levels for a plurality of pixels in the reconstructed image.

Claims (37)

1 . A method of processing medical image data using a processor, the method comprising:

receiving image data representing a medical image;

generating a reconstructed image based on the image data;

generating a mask from the image data and the reconstructed image using a pre-trained machine learning model, wherein the mask comprises a plurality of pixels, each pixel of the plurality of pixels in the mask corresponding to a corresponding pixel of a plurality of pixels in the reconstructed image in a manner that the each pixel of the plurality of pixels in the mask has a corresponding uncertainty value selected from at least three uncertainty levels, the uncertainty value for the each pixel of the plurality of pixels in the mask being based on a distance between the corresponding pixel of the plurality of pixels in the reconstructed image and a corresponding pixel of the image data; and

applying the mask to the reconstructed image to generate a masked reconstructed image.

2 . The method of claim 1 , wherein each of the at least three uncertainty levels is a value in a range of 0 to 1.

3 . The method of claim 1 , wherein generating the reconstructed image comprises colorization of the image data.

4 . The method of claim 1 , wherein generating the reconstructed image comprises identifying and estimating missing parts of the received image data.

5 . The method of claim 1 , wherein the image data represents an image of a first resolution, wherein the reconstructed image represents an image of a second resolution, and wherein the second resolution is higher than the first resolution.

6 . The method of claim 1 , wherein receiving the image data comprises collecting the image data from a medical device.

7 . The method of claim 6 , wherein the medical device is at least one of: an endoscope, a magnetic resonance imaging device, ultrasound device, and X-ray device.

8 . The method of claim 1 , wherein the pre-trained machine learning model is trained on a series of images to generate a mask for each image such that the distance between each masked reconstructed image and a corresponding true image is less than a first threshold with probability greater than a second threshold.

9 . The method of claim 1 , wherein the mask represents a visual representation of confidence that portions of the reconstructed image are accurate.

10 . The method of claim 1 , further comprising displaying the mask and the masked reconstructed image on a display.

11 . A system for processing medical image data comprising:

an input interface configured to receive image data;

a memory configured to store a plurality of processor-executable instructions, the memory comprising:

an image-to-image model;

a masking model, wherein the masking model comprises a pre-trained machine learning model; and

a processor configured to execute the plurality of processor-executable instructions to perform operations including:

receiving image data representing a medical image;

generating a reconstructed image based on the image data using the image-to-image model;

generating a mask from the image data and the reconstructed image using the masking model, wherein the mask comprises a plurality of pixels, each pixel of the plurality of pixels in the mask corresponding to a corresponding pixel of a plurality of pixels in the reconstructed image in a manner that the each pixel of the plurality of pixels in the mask has a corresponding uncertainty value selected from at least three uncertainty levels, the uncertainty value for the each pixel of the plurality of pixels in the mask being based on a distance between the corresponding pixel of the plurality of pixels in the reconstructed image and a corresponding pixel of the image data; and

generating a masked reconstructed image based on the reconstructed image and the mask.

12 . The system of claim 11 , wherein each of the at least three uncertainty levels is a value in a range of 0 to 1.

13 . The system of claim 11 , wherein the pre-trained machine learning model is trained on a series of images to generate a mask for each image such that the distance between each masked reconstructed image and a corresponding true image is less than a first threshold with probability greater than a second threshold.

14 . The system of claim 11 , wherein the mask represents a visual representation of confidence that portions of the reconstructed image are accurate.

15 . The system of claim 11 , further comprising displaying the mask and the masked reconstructed image on a display.

16 . A non-transitory processor-readable storage medium storing a plurality of processor-executable instructions for processing medical image data, the instructions being executed by a processor to perform operations comprising:

receiving image data representing at least one medical image;

generating a reconstructed image based on the image data;

generating a mask from the image data and the reconstructed image using a pre-trained machine learning model, wherein the mask comprises a plurality of pixels, each pixel of the plurality of pixels in the mask corresponding to a corresponding pixel of a plurality of pixels in the reconstructed image in a manner that the each pixel of the plurality of pixels in the mask has a corresponding uncertainty value selected from at least three uncertainty levels, the uncertainty value for the each pixel of the plurality of pixels in the mask being based on a distance between the corresponding pixel of the plurality of pixels in the reconstructed image and a corresponding pixel of the image data; and

generating a masked reconstructed image based on the reconstructed image and the mask.

17 . The non-transitory processor-readable storage medium of claim 16 , wherein each of the at least three uncertainty levels is a value in a range of 0 to 1.

18 . The non-transitory processor-readable storage medium of claim 16 , wherein the pre-trained machine learning model is trained on a series of images to generate a mask for each image such that the distance between each masked reconstructed image and a corresponding true image is less than a first threshold with probability greater than a second threshold.

19 . The non-transitory processor-readable storage medium of claim 16 , wherein the mask represents a visual representation of confidence that portions of the reconstructed image are accurate.

20 . The non-transitory processor-readable storage medium of claim 16 , further comprising displaying the mask and the masked reconstructed image on a display.

Assignments (2)
CHANGE OF NAME Recorded May 19, 2026
From: VERILY LIFE SCIENCES LLC
To: VERILY HEALTH INC.
Reel/Frame 075768/0309 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 7, 2023
From: FREEDMAN, DANIEL; COHEN, REGEV; KUTIEL, GILAD; ELAD, MICHAEL
To: VERILY LIFE SCIENCES LLC
Reel/Frame 064833/0222 →
Continuity (2)
Provisional Application 63482660 · Feb 1, 2023
Provisional Application 63410507 · Sep 27, 2022
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