Regulation of phospholipase D activity
Novel inhibitors of polyisoprenyl phosphate signaling regulates phopholipase D activity.
1. A method for treating phospholipase D (PLD) initiated polymorphoneutrophil (PMN) inflammation in a subject, comprising
administering to the subject an effective anti-inflammatory amount of a lipoxin analog having the formula
wherein R is a hydrogen atom, a pharmaceutically acceptable ester and pharmaceutically acceptable salts thereof, such that PLD initiated polymorphoneutrophil (PMN) inflammation is treated in a subject.
2. The method of claim 1 , wherein said method is performed in vitro.
3. The method of claim 1 , wherein said method is performed in vivo.
4. A method for treating phospholipase D (PLD) initiated superoxide generation or degranulation in a subject, comprising
administering to the subject an effective anti-PLD amount of a lipoxin analog having the formula
wherein R is a hydrogen atom, a pharmaceutically acceptable ester and pharmaceutically acceptable salts thereof, such that PLD initiated superoxide generation or granulation is treated in a subject.
5. The method of claim 4 , wherein said method is performed in vitro.
6. The method of claim 4 , wherein said method is performed in vivo.