Treatment of skin wounds using polyenylphosphatidylcholine and alkanolamines
View Patent ↗Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minmize scar formation. Typical compositions contain from about 0.25% to about 12% of a polyenylphosphatidylcholine preparation obtained from natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine, and from about 0.1% to about 10% by weight of an alkanolamine such as ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, or mixtures thereof. Dimethylaminoethanol is a particularly preferred alkanolamine. Tyrosine is an adjunct ingredient in many embodiments.
1. A method for the treatment of skin wounds comprising topically applying to the skin a composition containing an effective amount of polyenylphosphatidylcholine and an effective amount of an alkanolamine of the formula
wherein X, Y and Z are selected from the group consisting of hydrogen, C 1 -C 3 alkyl groups, C 2 -C 4 alkanol group, wherein at least one of X, Y, or Z is a C 2 -C 4 alkanol group bearing at least one hydroxyl group and optionally at least one carboxyl group.
2. A method according to claim 1 wherein dilinoleoylphosphatidylcholine is the most abundant phosphatidylcholine species in the polyenylphosphatidylcholine component of the composition, and the alkanolamine is selected from the group consisting of ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, and mixtures thereof.
3. A method according to claim 2 wherein dilinoleoylphosphatidylcholine comprises at least about 25% by weight of the polyenylphosphatidylcholine component.
4. A method according to claim 1 wherein the composition comprises from about 0.25% to about 12% by weight polyenylphosphatidylcholine, and from about 0.1% to about 10% by weight alkanolamine.
5. A method according to claim 4 wherein the composition contains from about 1% to about 12% by weight polyenylphosphatidylcholine, and from about 1% to about 3% alkanolamine.
6. A method according to claim 4 wherein the composition also contains from about 0.1% to about 5% by weight tyrosine.
7. A method according to claim 3 wherein the composition contains at least about 40% by weight dilinoleoylphosphatidyl choline in the polyenylphosphatidylcholine, and the alkanolamine is dimethylaminoethanol.
8. A method according to claim 6 wherein the polyenylphosphatidylcholine is obtained from soybean oil.
9. A method according to claim 1 wherein the skin wound is a cut or an abrasion.
10. A method according to claim 1 wherein the skin wound is a burn.
11. A method according to claim 1 wherein the skin wound is a blemish.
12. A method according to claim 1 which inhibits the formation of cutaneous scar tissue.
13. A method according to claim 1 wherein the composition is applied as a bandage.
14. A bandage impregnated with a composition containing an effective wound-healing amount of polyenylphosphatidylcholine and an alkanolamine selected from the group consisting of ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, and mixtures thereof.
15. A bandage according to claim 14 wherein dilinoleoylphosphatidylcholine comprises at least about 25% by weight of the polyenylphosphatidylcholine component, and the alkanolamine is dimethylaminoethanol.
16. A bandage according to claim 14 wherein the composition comprises from about 0.25% to about 10% by weight polyenylphosphatidylcholine, and from about 0.1% to about 10% alkanolamine.
17. A bandage according to claim 16 wherein the composition contains from about 1% to about 8% by weight polyenylphosphatidylcholine, and from about 1% to about 3% by weight alkanolamine.
18. A bandage according to claim 15 wherein the composition contains at least about 40% by weight dilinoleoylphosphatidyl choline in the polyenylphosphatidylcholine, and the alkanolamine is dimethylaminoethanol.
19. A bandage according to claim 18 wherein the polyenylphosphatidylcholine is obtained from soybean oil.
20. A bandage according to claim 14 which is a silicone gel sheet.
21. A bandage according to claim 14 wherein the composition further contains tyrosine.
22. A method for the treatment of skin wounds comprising topically applying to the skin a composition containing an effective wound-healing amount of polyenylphosphatidylcholine and another composition containing an alkanolamine selected from the group consisting of ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, and mixtures thereof.
23. A method according to claim 22 wherein either or both compositions further contain tyrosine.
24. A method according to claim 23 wherein the polyenylphosphatidyl choline composition comprises from about 0.25% to about 12% by weight polyenylphosphatidylcholine and the alkanolamine composition comprises from about 0.1% to about 10% by weight alkanolamine.
25. A composition for treating skin wounds comprising polyenylphosphatidylcholine and an alkanolamine of the formula
wherein X, Y and Z are selected from the group consisting of hydrogen, C 1 -C 3 alkyl groups, C 2 -C 4 alkanol group, wherein at least one of X, Y, or Z is a C 2 -C 4 alkanol group bearing at least one hydroxyl group and optionally at least one carboxyl group.
26. A composition according to claim 25 wherein dilinoleoylphosphatidylcholine is the most abundant phosphatidylcholine species in the polyenylphosphatidylcholine component of the composition, and the alkanolamine is selected from the group consisting of ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, and mixtures thereof.
27. A composition according to claim 26 wherein dilinoleoylphosphatidylcholine comprises at least about 25% by weight of the polyenylphosphatidylcholine component.
28. A composition according to claim 26 wherein the composition comprises from about 0.25% to about 25% by weight polyenylphosphatidylcholine, and from about 0.1% to about 10% by weight alkanolamine.
29. A composition according to claim 28 wherein the composition contains from about 1% to about 12% by weight polyenylphosphatidylcholine, and from about 1% to about 3% alkanolamine.
30. A composition according to claim 28 wherein the composition also contains from about 0.1% to about 5% by weight tyrosine.