Glutaminyl based DPIV inhibitors
View Patent ↗The present invention provides compounds of the formula: wherein X═CH 2 or S or pharmaceutical acceptable salts thereof useful for treating conditions mediated by DPIV or DPIV-like enzymes, such as arthritis, obesity, immune and autoimmune disorders, allograft transplantation, cancer, neuronal disorders and dermal diseases.
1. A compound of formula:
wherein X=CH2 or S or an acid addition salt thereof.
2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or diluent and a compound according to claim 1 .
3. A method of inhibiting dipeptidyl peptidase IV or dipeptidyl peptidase IV-like enzyme activity for the prevention or treatment of diseases or conditions related to dipeptidyl peptidase IV or dipeptidyl peptidase IV-like enzymes comprising administering a therapeutic amount of a compound according to claim 1 .
4. The method according to claim 3 wherein said treatment is for lowering elevated blood glucose levels in mammals resulting from food intake.
5. The method according to claim 3 for the prevention or treatment of diseases or conditions is selected from the group consisting of non-insulin-dependent diabetes mellitus, arthritis, obesity, immune and autoimmune disorders, allograft transplantation, cancer, neuronal disorders and dermal diseases.
6. A method for inhibiting dipeptidyl peptidase IV or dipeptidyl peptidase IV-like enzyme activity for preventing or treating diseases or conditions associated with dipeptidyl peptidase IV or dipeptidyl peptidase IV-like enzymes comprising administering to a mammal in need of such treatment a therapeutically effective amount of the compound according to claim 1 .
7. A method for inhibiting dipeptidyl peptidase IV or dipeptidyl peptidase IV-like enzyme activity for preventing or treating diseases or conditions associated with dipeptidyl peptidase IV or dipeptidyl peptidase IV-like enzymes comprising administering to a mammal in need of such treatment a therapeutically effective amount of the compound according to claim 2 .
8. A method for lowering elevated blood glucose levels in mammals resulting from food intake comprising administering to a mammal in need of such treatment a therapeutically effective amount of the compound according to claim 1 .
9. A method for preventing or treating diseases or conditions in a mammal selected from the group consisting of non-insulin-dependent diabetes mellitus, arthritis, obesity, immune and autoimmune disorders, allograft transplantation, cancer, neuronal disorders and dermal diseases comprising administering to said mammal a therapeutically effective amount of the compound according to claim 1 .