IP Library › Granted Patent US 6,946,514
Granted Patent B2
US 6,946,514 · App. 10/203,273 · Granted Sep 20, 2005

Adhesive preparation for external use

Assignee: Teikoko Seiyaku Co. Ltd.
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Quick Facts
Patent No.
US 6,946,514
App. No.
10/203,273
Granted
Sep 20, 2005
Kind
B2
Abstract

An external plaster using an aqueous hot melted type adhesive base material stably containing water-soluble drug having good drug releasability, so that bioavailability of the drug is enhanced, is provided. The aqueous hot melted type adhesive base material used in the external plaster comprising as essential components a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water.

Claims (38)

1. A external plaster using an aqueous hot melted type adhesive base material comprising a styrene-isoprene-styrene block copolymer an adhesive resin, an antioxidant, lanolin, and water, in the absence of a hydrophilic polymer.

2. The external plaster according to claim 1 , wherein the water is present in a range of 0.1 to 30%.

3. The external plaster according to claim 1 , wherein an active ingredient to be percutaneously absorbed is contained in the aqueous hot melted type adhesive base material.

4. The external plaster according to claim 2 , wherein an active ingredient to be percutaneously absorbed is contained in the aqueous hot melted type adhesive base material.

5. The external plaster according to claim 1 , wherein the styrene-isoprene-styrene block copolymer is present in an amount of 10 to 25% by weight.

6. The external plaster according to claim 5 , wherein the styrene-isoprene-styrene block copolymer is present in an amount of 15 to 25 % by weight.

7. The external plaster according to claim 1 , wherein the adhesive resin is selected from the group consisting of aromatic resins, aliphatic resins, alicyclic petroleum resins, rosin resins, rosin ester resins and terpene resins.

8. The external plaster according to claim 1 , wherein the adhesive resin is present in an amount of from 15 to 35% by weight.

9. The external plaster according to claim 8 , wherein the adhesive resin is present in an amount of from 20 to 30% by weight.

10. The external plaster according to claim 1 , wherein the antioxidant is selected from the group consisting of dibutylhydroxytoluene, pentaerythrityl-tetrakis[3-(3,5-di-t-butyl-4-hydroxyphenyl)]propionate, and tocopherol acetate.

11. The external plaster according to claim 1 , wherein the antioxidant is present in an amount of 0.1 to 2% by weight.

12. The external plaster according to claim 1 , wherein the lanolin is present in an amount of from 5 to 40% by weight.

13. The external plaster according to claim 12 , wherein the lanolin is present in an amount of from 10 to 30% by weight.

14. The external plaster according to claim 2 , wherein the water is present in an amount of from 0.3 to 20% by weight.

15. An external plaster using an aqueous hot melted type adhesive base material consisting essentially of a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water.

16. The external plaster according to claim 15 , wherein the water is present in a range of 0.1 to 30%.

17. The external plaster according to claim 15 , wherein an active ingredient to be percutaneously absorbed is contained in the aqueous hot melted type adhesive base material.

18. The external plaster according to claim 16 , wherein an active ingredient to be percutaneously absorbed is contained in the aqueous hot melted type adhesive base material.

19. The external plaster according to claim 15 , wherein the styrene-isoprene-styrene block copolymer is present in an amount of 10 to 25% by weight.

20. The external plaster according to claim 19 , wherein the styrene-isoprene-styrene block copolymer is present in an amount of 15 to 25% by weight.

21. The external plaster according to claim 15 , wherein the adhesive resin is selected from the group consisting of aromatic resins, aliphatic resins, alicyclic petroleum resins, rosin resins, rosin ester resins and terpene resins.

22. The external plaster according to claim 15 , wherein the adhesive resin is present in an amount of from 15 to 35% by weight.

23. The external plaster according to claim 22 , wherein the adhesive resin is present in an amount of from 20 to 30% by weight.

24. The external plaster according to claim 15 , wherein the antioxidant is selected from the group consisting of dibutylhydroxytoluene, pentaerythrityl-tetrakis[3-(3,5-di-t-butyl-4-hydroxyphenyl)]propionate, and tocopherol acetate.

25. The external plaster according to claim 15 , wherein the antioxidant is present in an amount of 0.1 to 2% by weight.

26. The external plaster according to claim 15 , wherein the lanolin is present in an amount of from 5 to 40% by weight.

27. The external plaster according to claim 26 , wherein the lanolin is present in an amount of from 10 to 30% by weight.

28. The external plaster according to claim 16 , wherein the water is present in an amount of from 0.3 to 20% by weight.

29. A process for producing an aqueous hot melted type adhesive base material, which comprises melting and kneading a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water, in the absence of a hydrophilic polymer, at a temperature at which the water will not boil.

30. The process according to claim 29 , wherein said styrene-isoprene-styrene block copolymer, adhesive resin, antioxidant, lanolin, and water are kneaded at a temperature of 80 to 100° C.

31. The process according to claim 30 , wherein said styrene-isoprene-styrene block copolymer, adhesive resin, antioxidant, lanolin, and water are kneaded at a temperature of about 90° C.

32. The process according to claim 29 , wherein said styrene-isoprene-styrene block copolymer, adhesive resin, antioxidant, and lanolin are mixed and kneaded in a kneader heated to about 150° C. and then cooled.

33. The process according to claim 32 , further comprising adding warm water and an aqueous solution of an active ingredient to be percutaneously absorbed after said cooling step.

34. A process for producing an aqueous hot melted type adhesive base material, comprising melting and kneading ingredients consisting essentially of a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water at a temperature at which the water will not boil.

35. The process according to claim 34 , wherein said styrene-isoprene-styrene block copolymer, adhesive resin, antioxidant, lanolin, and water are kneaded at a temperature of 80 to 100° C.

36. The process according to claim 35 , wherein said styrene-isoprene-styrene block copolymer, adhesive resin, antioxidant, lanolin, and water are kneaded at a temperature of about 90° C.

37. The process according to claim 34 , wherein said styrene-isoprene-styrene block copolymer, adhesive resin, antioxidant, and lanolin are mixed and kneaded in a kneader heated to about 150° C. and then cooled.

38. The process according to claim 37 , including the step of adding warm water and an aqueous solution of an active ingredient to be percutaneously absorbed after said cooling step.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2002
From: KAWAJI, TOSHIKUNI
To: TEIKOKU SEIYAKU CO., LTD.
Reel/Frame 013350/0124 →
Continuity (1)
Related Publication 20030100852A1 · May 29, 2003