Emulsion vehicle for poorly soluble drugs
An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.
1. A method of administering a chemotherapeutic agent to a subject suffering from cancer, comprising:
providing a pharmaceutical composition comprising a chemotherapeutic agent, wherein the chemotherapeutic agent is at least one of a taxoid, a taxane, or a taxine; α-tocopherol; a tocopherol polyethylene glycol succinate; and an aqueous phase; wherein the composition is an emulsion or a microemulsion having an oil phase and a water phase, and wherein all of the chemotherapeutic agent is in the oil phase; and
administering the pharmaceutical composition in a therapeutically effective amount to a subject suffering from cancer.
2. The method of claim 1 , wherein the chemotherapeutic agent is paclitaxel.
3. The method of claim 2 , wherein the concentration of the paclitaxel in the composition is at least about 5 mg/ml.
4. The method of claim 2 , wherein the concentration of the paclitaxel in the composition is at least about 10 mg/ml.
5. The method of claim 2 , wherein the concentration of the paclitaxel in the composition is at least about 20 mg/ml.
6. The method of claim 1 , wherein the composition further comprises polyethylene glycol.
7. The method of claim 1 , wherein the composition further comprises a polyoxypropylene-polyoxyethylene glycol nonionic block co-polymer.
8. The method of claim 1 , wherein the composition is administered parenterally.
9. The method of claim 1 , wherein the composition is administered by intravenous infusion over a period of less than 3 hours.
10. The method of claim 1 , wherein the composition is administered by bolus injection.
11. A method of treating a carcinoma in a subject suffering therefron, comprising:
providing a pharmaceutical composition comprising a chemotherapeutic agent, wherein the chemotherapeutic agent is at least one of a taxoid, a taxane, or a taxine; α-tocepherol a tocopherol polyethylene glycol succinate; and an aqueous phase; wherein the composition is an emulsion or a microemulsion having an oil phase and a water phase, and wherein all of the chemotherapeutic agent is in the oil phase; and
administering the pharmaceutical composition in a therapeutically effective amount to a subject suffering from a carcinoma.
12. The method of claim 11 , wherein the chemotherapeutic agent is paclitaxel.
13. The method of claim 12 , wherein the concentration of the paclitaxel in the composition is at least about 5 mg/ml.
14. The method of claim 12 , wherein the concentration of the paclitaxel in the composition is at least about 10 mg/ml.
15. The method of claim 11 , wherein the composition further comprises polyethylene glycol.
16. The method of claim 11 , wherein the composition further comprises a polyoxypropylene-polyoxyethylene glycol nonionic block co-polymer.
17. The method of claim 11 , wherein the composition is administered parenterally.
18. The method of claim 11 , wherein the composition is administered by intravenous infusion over a period of less than 3 hours.
19. The method of claim 11 , wherein the composition is administered by bolus injection.
20. The method of claim 11 , wherein the carcinoma is a breast carcinoma.
21. The method of claim 11 , wherein the carcinoma is a lung carcinoma.
22. The method of claim 11 , wherein the carcinoma is a skin carcinoma.
23. The method of claim 11 , wherein the carcinoma is a uterus carcinoma.