Appetite-stimulating agents and remedies for anorexia
An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I): wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted, the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted, W represents a single bond or —CH═CH—, X represents —N(R 1 )— or an oxygen atom, Y represents a carbon atom or a nitrogen atom, Z represents —N(R 2 )— or a nitrogen atom, and R 1 and R 2 may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.
1. A method for stimulating appetite, comprising administering to a subject in need of appetite stimulation, an effective amount of a sulfonamide derivative or sulfonic acid ester derivative represented by formula (I):
or a pharmacologically acceptable salt thereof, or a hydrate thereof,
wherein ring A represents a monocyclic or bicyclic aromatic ring which is optionally substituted,
ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, wherein the hydrocarbon ring or the heterocyclic ring is optionally substituted,
ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, wherein ring C is optionally substituted,
W represents a single bond or —CH═CH—,
X represents —N(R 1 )— or an oxygen atom,
Y represents a carbon atom or a nitrogen atom,
Z represents —N(R 2 )— or a nitrogen atom, and
R 1 and R 2 may be identical or different and each represents a hydrogen atom or a lower alkyl group.
2. The method according to claim 1 , wherein W is a single bond.
3. The method according to claim 2 , wherein X and Z are —NH—, and Y is a carbon atom.
4. The method according to claim 1 , wherein ring B is benzene or pyridine, wherein the benzene or the pyridine is optionally substituted.
5. The method according to claim 1 , wherein ring C is pyrrole which is optionally substituted.
6. The method according to claim 1 , wherein ring A is benzene or pyridine, wherein the benzene or the pyridine is optionally substituted; ring B is benzene which is optionally substituted; ring C is pyrrole which is optionally substituted; W is a single bond; and X and Z are —NH—.
7. A method of treating anorexia, comprising administering to a mammal in need of treatment of anorexia, an effective amount of a sulfonamide derivative or sulfonic acid ester derivative represented by formula (I):
or a pharmacologically acceptable salt thereof, or a hydrate thereof,
wherein ring A represents a monocyclic or bicyclic aromatic ring which is optionally substituted,
ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, wherein the hydrocarbon ring or the heterocyclic ring is optionally substituted,
ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, wherein ring C is optionally substituted,
W represents a single bond or —CH═CH—,
X represents —N(R 1 )— or an oxygen atom,
Y represents a carbon atom or a nitrogen atom,
Z represents —N(R 2 )— or a nitrogen atom, and
R 1 and R 2 may be identical or different and each represents a hydrogen atom or a lower alkyl group.
8. The method according to claim 7 , wherein W is a single bond.
9. The method according to claim 8 , wherein X and Z are —NH—, and Y is a carbon atom.
10. The method according to claim 7 , wherein ring B is benzene or pyridine, wherein the benzene or the pyridine is optionally substituted.
11. The method according to claim 7 , wherein ring C is pyrrole which is optionally substituted.
12. The method according to claim 7 , wherein ring A is benzene or pyridine, wherein the benzene or the pyridine is optionally substituted; ring B is benzene which is optionally substituted; ring C is pyrrole which is optionally substituted; W is a single bond; and X and Z are —NH—.
13. The method according to claim 7 , wherein the anorexia is a disease selected from the group consisting of anorexia nervosa, apocleisis emaciation, and anorexia and emaciation accompanying cancerous cachexia.
14. The method according to claim 13 , wherein the anorexia is anorexia and emaciation accompanying cancerous cachexia, and the method further comprises administering to the mammal an anticancer drug.